PMID- 2523351
OWN - NLM
STAT- MEDLINE
DCOM- 19890601
LR  - 20210526
IS  - 0019-9567 (Print)
IS  - 1098-5522 (Electronic)
IS  - 0019-9567 (Linking)
VI  - 57
IP  - 5
DP  - 1989 May
TI  - Regulation of immunoglobulin E production in mice immunized with an extract of 
      Toxoplasma gondii.
PG  - 1405-8
AB  - Repeated infection with Toxoplasma gondii could not induce immunoglobulin E (IgE) 
      antibody production. When mice were injected intraperitoneally twice over a 
      3-week interval with an extract of tachyzoites of T. gondii and Al(OH)3 as 
      adjuvant, antitoxoplasma IgE antibody was produced. Antitoxoplasma IgE antibody 
      titers were low and diminished after a short time in B10.S, BALB/c, C3H, and 
      C57BL/6 mice. This tendency was more evident in IgE low-responder SJL mice. 
      IgE-inducing activity of Toxoplasma antigen was weaker than those of keyhole 
      limpet hemocyanin, ovalbumin, and an extract from Nippostrongylus brasiliensis. 
      The antitoxoplasma IgE antibody production was enhanced by and persisted after 
      whole-body irradiation (150 R) following secondary immunization. The enhanced 
      antitoxoplasma IgE antibody production was suppressed by transferring spleen 
      cells from Toxoplasma antigen-immunized mice. The suppressive effect of the 
      spleen cells was Toxoplasma antigen specific and was removed by treatment with 
      anti-Thy-1.2 and complement. These results indicate that the low IgE production 
      induced by Toxoplasma antigen is the result of irradiation-sensitive and 
      antigen-specific suppressor T cells. These findings might explain the lack of IgE 
      antibody response in mice with Toxoplasma infection.
FAU - Watanabe, N
AU  - Watanabe N
AD  - Department of Parasitology, Jikei University School of Medicine, Tokyo, Japan.
FAU - Kobayashi, A
AU  - Kobayashi A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Infect Immun
JT  - Infection and immunity
JID - 0246127
RN  - 0 (Antibodies, Protozoan)
RN  - 0 (Antigens, Protozoan)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Antibodies, Protozoan/*biosynthesis
MH  - Antigens, Protozoan/*immunology
MH  - Immune Tolerance
MH  - Immunization
MH  - Immunoglobulin E/*biosynthesis
MH  - Mice
MH  - Spleen/immunology
MH  - T-Lymphocytes, Regulatory/immunology
MH  - Toxoplasma/*immunology
MH  - Toxoplasmosis, Animal/*immunology
PMC - PMC313290
EDAT- 1989/05/01 00:00
MHDA- 1989/05/01 00:01
PMCR- 1989/05/01
CRDT- 1989/05/01 00:00
PHST- 1989/05/01 00:00 [pubmed]
PHST- 1989/05/01 00:01 [medline]
PHST- 1989/05/01 00:00 [entrez]
PHST- 1989/05/01 00:00 [pmc-release]
AID - 10.1128/iai.57.5.1405-1408.1989 [doi]
PST - ppublish
SO  - Infect Immun. 1989 May;57(5):1405-8. doi: 10.1128/iai.57.5.1405-1408.1989.