PMID- 25234163
OWN - NLM
STAT- MEDLINE
DCOM- 20150406
LR  - 20221207
IS  - 1617-4623 (Electronic)
IS  - 1617-4623 (Linking)
VI  - 290
IP  - 1
DP  - 2015 Feb
TI  - A MCP-1 promoter polymorphism at G-2518A is associated with spontaneous preterm 
      birth.
PG  - 289-96
LID - 10.1007/s00438-014-0921-6 [doi]
AB  - Monocyte chemoattractant protein-1 (MCP-1) is an important chemokine involved in 
      the pathogenesis of spontaneous preterm birth (SPTB). We examined whether the 
      MCP-1 G-2518A polymorphism is associated with the risk of SPTB in a Chinese 
      population. The MCP-1 G-2518A polymorphism was genotyped in 569 preterm singleton 
      neonates and in 673 term neonates using polymerase chain reaction-restriction 
      fragment length polymorphism analysis. The distribution of the MCP-1 G-2518A 
      genotype and the allele frequencies between the SPTB patients and the controls 
      were not significantly different in the overall sample. However, we found that 
      the AA genotype was associated with significantly increased susceptibility to 
      very SPTB (<32 weeks) [odds ratio (OR) 2.07; 95 % confidence interval (CI), 
      1.27-3.36; P = 0.005) and extremely SPTB (<28 weeks) (OR 2.74; 95 % CI, 
      1.10-6.72; P = 0.014) compared with -2518G-positive genotypes (GG + GA 
      genotypes). When extremely preterm neonates and very preterm neonates were 
      combined, the AA genotype was also significantly associated with increased 
      susceptibility to SPTB (OR 2.23; 95 % CI, 1.40-3.54; P < 0.001). The MCP-1 
      G-2518A polymorphism was not associated with increased susceptibility to SPTB in 
      patients with premature rupture of the membranes (PROM) or in those without PROM. 
      Our findings suggest that the MCP-1 G-2518A polymorphism may plays a role in 
      mediating the susceptibility to SPTB in the Chinese population. Knowledge of 
      genetic factors contributing to the pathogenesis of SPTB may have implications 
      for screening and treatment of this disorder.
FAU - Wang, Yan
AU  - Wang Y
AD  - BaYi Children's Hospital, General Military Hospital of Beijing PLA, 5 Nanmencang 
      Road, Dongcheng District, Beijing, 100700, People's Republic of China.
FAU - Zhang, Xiao-Ai
AU  - Zhang XA
FAU - Yang, Xiao
AU  - Yang X
FAU - Wu, Zhi-Hao
AU  - Wu ZH
FAU - Feng, Zhi-Chun
AU  - Feng ZC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140919
PL  - Germany
TA  - Mol Genet Genomics
JT  - Molecular genetics and genomics : MGG
JID - 101093320
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Adult
MH  - Asian People/genetics
MH  - Case-Control Studies
MH  - Chemokine CCL2/*genetics
MH  - Demography
MH  - Ethnicity/genetics
MH  - Female
MH  - Gene Frequency/genetics
MH  - *Genetic Association Studies
MH  - Humans
MH  - Infant, Newborn
MH  - Male
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Pregnancy
MH  - Premature Birth/*genetics
MH  - *Promoter Regions, Genetic
EDAT- 2014/09/23 06:00
MHDA- 2015/04/07 06:00
CRDT- 2014/09/20 06:00
PHST- 2014/04/25 00:00 [received]
PHST- 2014/09/11 00:00 [accepted]
PHST- 2014/09/20 06:00 [entrez]
PHST- 2014/09/23 06:00 [pubmed]
PHST- 2015/04/07 06:00 [medline]
AID - 10.1007/s00438-014-0921-6 [doi]
PST - ppublish
SO  - Mol Genet Genomics. 2015 Feb;290(1):289-96. doi: 10.1007/s00438-014-0921-6. Epub 
      2014 Sep 19.