PMID- 25234319
OWN - NLM
STAT- MEDLINE
DCOM- 20150812
LR  - 20221207
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 280
DP  - 2014 Nov 7
TI  - BDNF Val66Met polymorphism influence on striatal blood-level-dependent response 
      to monetary feedback depends on valence and agency.
PG  - 130-41
LID - S0306-4522(14)00756-8 [pii]
LID - 10.1016/j.neuroscience.2014.09.014 [doi]
AB  - Animal work implicates the brain-derived neurotrophic factor (BDNF) in function 
      of the ventral striatum (VS), a region known for its role in processing valenced 
      feedback. Recent evidence in humans shows that BDNF Val66Met polymorphism 
      modulates VS activity in anticipation of monetary feedback. However, it remains 
      unclear whether the polymorphism impacts the processing of self-attributed 
      feedback differently from feedback attributed to an external agent. In this 
      study, we emphasize the importance of the feedback attribution because agency is 
      central to computational accounts of the striatum and cognitive accounts of 
      valence processing. We used functional magnetic resonance imaging and a task, in 
      which financial gains/losses are either attributable to performance 
      (self-attributed, SA) or chance (externally-attributed, EA) to ask whether BDNF 
      Val66Met polymorphism predicts VS activity. We found that BDNF Val66Met 
      polymorphism influenced how feedback valence and agency information were combined 
      in the VS and in the right inferior frontal junction (IFJ). Specifically, Met 
      carriers' VS response to valenced feedback depended on agency information, while 
      Val/Val carriers' VS response did not. This context-specific modulation of 
      valence effectively amplified VS responses to SA losses in Met carriers. The IFJ 
      response to SA losses also differentiated Val/Val from Met carriers. These 
      results may point to a reduced allocation of attention and altered motivational 
      salience to SA losses in Val/Val compared to Met carriers. Implications for major 
      depressive disorder are discussed.
CI  - Copyright (c) 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Chumbley, J
AU  - Chumbley J
AD  - Laboratory for Social and Neural Systems Research, Department of Economics, 
      University of Zurich, Switzerland.
FAU - Spati, J
AU  - Spati J
AD  - Department of Psychophysiology, National Institute of Mental Health, National 
      Center of Neurology and Psychiatry, Tokyo, Japan.
FAU - Dorig, N
AU  - Dorig N
AD  - Department of Psychology, University of Zurich, Switzerland; Neuroscience Center, 
      University and ETH Zurich, Switzerland.
FAU - Brakowski, J
AU  - Brakowski J
AD  - Department of Psychiatry, Psychotherapy and Psychosomatics, Hospital of 
      Psychiatry, University of Zurich, Switzerland.
FAU - Grosse Holtforth, M
AU  - Grosse Holtforth M
AD  - Department of Psychology, University of Zurich, Switzerland; Department of 
      Psychology, University of Bern, Switzerland.
FAU - Seifritz, E
AU  - Seifritz E
AD  - Neuroscience Center, University and ETH Zurich, Switzerland; Department of 
      Psychiatry, Psychotherapy and Psychosomatics, Hospital of Psychiatry, University 
      of Zurich, Switzerland; Zurich Center for Integrative Human Physiology, 
      University of Zurich, Switzerland.
FAU - Spinelli, S
AU  - Spinelli S
AD  - Neuroscience Center, University and ETH Zurich, Switzerland; Zurich Center for 
      Integrative Human Physiology, University of Zurich, Switzerland; Preclinical 
      Laboratory for Translational Research into Affective Disorders, Department of 
      Psychiatry, Psychotherapy and Psychosomatics, Hospital of Psychiatry, University 
      of Zurich, Switzerland. Electronic address: spinellisimona@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140916
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Brain Mapping
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Cerebrovascular Circulation/physiology
MH  - Feedback, Psychological/*physiology
MH  - Female
MH  - Frontal Lobe/blood supply/physiology
MH  - Genotyping Techniques
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Motion Perception/physiology
MH  - Neuropsychological Tests
MH  - *Polymorphism, Single Nucleotide
MH  - Psychometrics
MH  - Reinforcement, Psychology
MH  - Self Concept
MH  - Ventral Striatum/blood supply/*physiology
MH  - White People/genetics
MH  - Young Adult
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor gene
OT  - Val66Met
OT  - feedback processing
OT  - functional magnetic resonance imaging
OT  - inferior frontal junction
OT  - ventral striatum
EDAT- 2014/09/23 06:00
MHDA- 2015/08/13 06:00
CRDT- 2014/09/20 06:00
PHST- 2014/07/03 00:00 [received]
PHST- 2014/09/01 00:00 [revised]
PHST- 2014/09/08 00:00 [accepted]
PHST- 2014/09/20 06:00 [entrez]
PHST- 2014/09/23 06:00 [pubmed]
PHST- 2015/08/13 06:00 [medline]
AID - S0306-4522(14)00756-8 [pii]
AID - 10.1016/j.neuroscience.2014.09.014 [doi]
PST - ppublish
SO  - Neuroscience. 2014 Nov 7;280:130-41. doi: 10.1016/j.neuroscience.2014.09.014. 
      Epub 2014 Sep 16.