PMID- 25234717
OWN - NLM
STAT- MEDLINE
DCOM- 20150511
LR  - 20220321
IS  - 1423-0380 (Electronic)
IS  - 1010-4283 (Linking)
VI  - 36
IP  - 1
DP  - 2015 Jan
TI  - Genetic variations in monocyte chemoattractant protein-1 and susceptibility to 
      ovarian cancer.
PG  - 233-8
LID - 10.1007/s13277-014-2619-0 [doi]
AB  - Monocyte chemoattractant protein-1 (MCP-1) is a chemokine which plays critical 
      roles in regulating host immune responses. Researches have shown that MCP-1 may 
      greatly participate in the development of different cancers. In the current 
      study, we investigated the effect of MCP-1 on ovarian cancer by examining the 
      association between MCP-1 genetic polymorphisms and the susceptibility to ovarian 
      cancer. MCP-1 -2158A/G and MCP-1 -362C/G polymorphisms were examined in ovarian 
      cancer patients and healthy controls by using polymerase chain 
      reaction-restriction fragment length polymorphism analysis. Results showed that 
      percentages of MCP-1 -2158GG genotype and G allele were significantly higher in 
      ovarian cancer patients than in controls (odd ratio (OR) = 1.87; 95 % confidence 
      interval (CI), 1.19-2.76; P = 0.012 and OR = 1.47; 95 % CI, 1.11-1.79; P = 0.003; 
      data were adjusted for age and smoking status). The MCP-1 -362GG genotype also 
      revealed increased number in patients. Stratification analyses presented that 
      ovarian cancer cases with serous-papillary type had significantly increased 
      percentage of -362GG genotype than those with other types (13.1 versus 5.0 %, 
      P = 0.032; data were adjusted for age and smoking status). Also, we evaluated the 
      relation between these two polymorphisms and serum level of MCP-1. We identified 
      that the subjects with MCP-1 -2158AG and GG genotypes had clearly increased serum 
      level of MCP-1 than those with AA genotype. These data suggest that MCP-1 may be 
      involved in the pathogenesis of ovarian cancer.
FAU - Li, Li
AU  - Li L
AD  - Department of Gynaecology, Affiliated Tumor Hospital, Xinjiang Medical 
      University, Urumqi, Xinjiang, 830011, China.
FAU - Zhang, Jinshan
AU  - Zhang J
FAU - Weng, Xin
AU  - Weng X
FAU - Wen, Ge
AU  - Wen G
LA  - eng
PT  - Journal Article
DEP - 20140919
PL  - Netherlands
TA  - Tumour Biol
JT  - Tumour biology : the journal of the International Society for Oncodevelopmental 
      Biology and Medicine
JID - 8409922
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Case-Control Studies
MH  - Chemokine CCL2/blood/*genetics
MH  - Female
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Middle Aged
MH  - Neoplasms, Cystic, Mucinous, and Serous/blood/*genetics
MH  - Ovarian Neoplasms/blood/*genetics
MH  - Polymorphism, Single Nucleotide
MH  - Sequence Analysis, DNA
EDAT- 2014/09/23 06:00
MHDA- 2015/05/12 06:00
CRDT- 2014/09/20 06:00
PHST- 2014/08/06 00:00 [received]
PHST- 2014/09/09 00:00 [accepted]
PHST- 2014/09/20 06:00 [entrez]
PHST- 2014/09/23 06:00 [pubmed]
PHST- 2015/05/12 06:00 [medline]
AID - 10.1007/s13277-014-2619-0 [doi]
PST - ppublish
SO  - Tumour Biol. 2015 Jan;36(1):233-8. doi: 10.1007/s13277-014-2619-0. Epub 2014 Sep 
      19.