PMID- 25236555 OWN - NLM STAT- MEDLINE DCOM- 20190507 LR - 20190507 IS - 1866-3370 (Print) IS - 1866-3370 (Linking) VI - 5 DP - 2011 TI - Synaptic plasticity in the pathophysiology and treatment of bipolar disorder. PG - 167-85 LID - 10.1007/7854_2010_65 [doi] AB - Emerging evidence suggests that synaptic plasticity is intimately involved in the pathophysiology and treatment of bipolar disorder (BPD). Under certain conditions, over-strengthened and/or weakened synapses at different circuits in the brain could disturb brain functions in parallel, causing manic-like or depressive-like behaviors in animal models. In this chapter, we summarize the regulation of synaptic plasticity by medications, psychological conditions, hormones, and neurotrophic factors, and their correlation with mood-associated animal behaviors. We conclude that increased serotonin, norepinephrine, dopamine, brain-derived neurotrophic factor (BDNF), acute corticosterone, and antidepressant treatments lead to enhanced synaptic strength in the hippocampus and also correlate with antidepressant-like behaviors. In contrast, inhibiting monoaminergic signaling, long-term stress, and pathophysiological concentrations of cytokines weakens glutamatergic synaptic strength in the hippocampus and is associated with depressive-like symptoms. FAU - Du, Jing AU - Du J AD - Laboratory of Molecular Pathophysiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, 9000 Rockville Pike, Building 35, 1BC909, Bethesda, MD, 20892, USA, duj@mail.nih.gov. FAU - Machado-Vieira, Rodrigo AU - Machado-Vieira R FAU - Khairova, Rushaniya AU - Khairova R LA - eng PT - Journal Article PL - Germany TA - Curr Top Behav Neurosci JT - Current topics in behavioral neurosciences JID - 101535383 RN - 0 (Antidepressive Agents) RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - Animals MH - *Antidepressive Agents/therapeutic use MH - *Bipolar Disorder/pathology MH - Brain-Derived Neurotrophic Factor/metabolism MH - Disease Models, Animal MH - *Hippocampus/physiopathology MH - Humans MH - *Neuronal Plasticity MH - Synapses EDAT- 2011/01/01 00:00 MHDA- 2011/01/01 00:01 CRDT- 2014/09/20 06:00 PHST- 2014/09/20 06:00 [entrez] PHST- 2011/01/01 00:00 [pubmed] PHST- 2011/01/01 00:01 [medline] AID - 10.1007/7854_2010_65 [doi] PST - ppublish SO - Curr Top Behav Neurosci. 2011;5:167-85. doi: 10.1007/7854_2010_65.