PMID- 25236607
OWN - NLM
STAT- MEDLINE
DCOM- 20150804
LR  - 20141208
IS  - 1879-0003 (Electronic)
IS  - 0141-8130 (Linking)
VI  - 72
DP  - 2015 Jan
TI  - Anti-diabetic effects of polysaccharides from Talinum triangulare in 
      streptozotocin (STZ)-induced type 2 diabetic male mice.
PG  - 575-9
LID - S0141-8130(14)00610-2 [pii]
LID - 10.1016/j.ijbiomac.2014.09.011 [doi]
AB  - The present study evaluated the anti-diabetic effects of the polysaccharides 
      obtained from Talinum triangulare (TTP). Two TTP doses (150 mg/kg and 300 mg/kg . 
      bw/d) were administered orally to normal and streptozotocin (STZ)-induced type 2 
      diabetic male Kunming mice, respectively. The TTP hypoglycemic and hypolipidemic 
      effects were evaluated by testing the fast blood glucose (FBG) level, fasting 
      serum insulin (FINS), and serum lipids (TC, TG, HDL, LDL) as well as the body, 
      hepar and kidney weights. After four weeks administration, the low-dose group 150 
      mg/kg . bw/d) and high-dose group (300 mg/kg . bw/d) showed a marked FBG fall 
      rate of 29.85% and 41.18% (FBG fall rate% = ((Diabetic control--TTP 
      group)/Diabetic control) x 100%). The results of FBG and serum lipids indicate 
      that TTP possess significant hypoglycemic effect, but no significant 
      hypolipidemic effect. These results suggest the potential use of TTP as a 
      functional food for the treatment of type 2 diabetic mellitus (T2DM).
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Xu, Wei
AU  - Xu W
AD  - College of Food Science and Technology, Huazhong Agricultural University, Wuhan 
      430070, China.
FAU - Zhou, Qing
AU  - Zhou Q
AD  - Department of Pharmacy, Wuhan City Central Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan 430014, China.
FAU - Yin, Jiao-jiao
AU  - Yin JJ
AD  - College of Food Science and Technology, Huazhong Agricultural University, Wuhan 
      430070, China.
FAU - Yao, Yong
AU  - Yao Y
AD  - College of Food Science and Technology, Huazhong Agricultural University, Wuhan 
      430070, China.
FAU - Zhang, Jiu-liang
AU  - Zhang JL
AD  - College of Food Science and Technology, Huazhong Agricultural University, Wuhan 
      430070, China; Key Laboratory of Environment Correlative Dietology (Huazhong 
      Agricultural University), Ministry of Education, Wuhan 43000, China. Electronic 
      address: zjl_ljz@mail.hzau.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140916
PL  - Netherlands
TA  - Int J Biol Macromol
JT  - International journal of biological macromolecules
JID - 7909578
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 0 (Lipids)
RN  - 0 (Plant Extracts)
RN  - 0 (Polysaccharides)
SB  - IM
MH  - Animals
MH  - Blood Glucose
MH  - Diabetes Mellitus, Experimental/blood/*drug therapy/pathology
MH  - Diabetes Mellitus, Type 2/blood/*drug therapy/pathology
MH  - Humans
MH  - Insulin/blood
MH  - Lipids/blood
MH  - Male
MH  - Mice
MH  - Mice, Inbred NOD
MH  - Plant Extracts/*administration & dosage/chemistry
MH  - Polysaccharides/*administration & dosage/chemistry
OTO - NOTNLM
OT  - Anti-diabetic effects
OT  - Hypoglycemic
OT  - Hypolipidemic
OT  - Polysaccharides
OT  - Talinum triangulare
EDAT- 2014/09/23 06:00
MHDA- 2015/08/05 06:00
CRDT- 2014/09/20 06:00
PHST- 2014/08/05 00:00 [received]
PHST- 2014/09/08 00:00 [revised]
PHST- 2014/09/08 00:00 [accepted]
PHST- 2014/09/20 06:00 [entrez]
PHST- 2014/09/23 06:00 [pubmed]
PHST- 2015/08/05 06:00 [medline]
AID - S0141-8130(14)00610-2 [pii]
AID - 10.1016/j.ijbiomac.2014.09.011 [doi]
PST - ppublish
SO  - Int J Biol Macromol. 2015 Jan;72:575-9. doi: 10.1016/j.ijbiomac.2014.09.011. Epub 
      2014 Sep 16.