PMID- 25237476
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140919
LR  - 20231104
IS  - 2035-3006 (Print)
IS  - 2035-3006 (Electronic)
IS  - 2035-3006 (Linking)
VI  - 6
IP  - 1
DP  - 2014
TI  - Advanced hodgkin lymphoma: a new era of therapy.
PG  - e2014063
LID - 10.4084/MJHID.2014.063 [doi]
LID - e2014063
AB  - Therapy of advanced Hodgkin lymphoma (HL) is a rapidly changing field due to a 
      lot of currently emerging data. Treatment approaches are presently based on 
      either the Kairos principle of giving aggressive therapy upfront and considering 
      de-escalation of therapy if the interim PET/CT is negative or the Chronos 
      principle of starting with ABVD followed by escalation of therapy for patients 
      with positive interim PET/CT. The International Prognostic Score (IPS) is still 
      valid for decision-making regarding the type of initial therapy, since patients 
      with a high score do have an inferior progression free survival (PFS) with ABVD 
      compared to those with a low score. Escalated BEACOPP administered upfront 
      improves PFS; however, increase in the overall survival (OS) has not been 
      confirmed yet, and this therapy is accompanied by elevated toxicity and fertility 
      impairment. Completion of ongoing and currently initiated trials could elucidate 
      multiple issues related to the management of HL patients.
FAU - Dann, Eldad J
AU  - Dann EJ
AD  - Department of Hematology and Bone Marrow Transplantation ; Blood Bank and 
      Transfusion Service, Rambam Health Care Campus ; Bruce Rappaport Faculty of 
      Medicine, Technion, Israel Institute of Technology.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140905
PL  - Italy
TA  - Mediterr J Hematol Infect Dis
JT  - Mediterranean journal of hematology and infectious diseases
JID - 101530512
PMC - PMC4165498
EDAT- 2014/09/23 06:00
MHDA- 2014/09/23 06:01
PMCR- 2014/01/01
CRDT- 2014/09/20 06:00
PHST- 2014/03/11 00:00 [received]
PHST- 2014/09/04 00:00 [accepted]
PHST- 2014/09/20 06:00 [entrez]
PHST- 2014/09/23 06:00 [pubmed]
PHST- 2014/09/23 06:01 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - mjhid-6-1-e2014063 [pii]
AID - 10.4084/MJHID.2014.063 [doi]
PST - epublish
SO  - Mediterr J Hematol Infect Dis. 2014 Sep 5;6(1):e2014063. doi: 
      10.4084/MJHID.2014.063. eCollection 2014.