PMID- 25240248
OWN - NLM
STAT- MEDLINE
DCOM- 20150615
LR  - 20181202
IS  - 1872-8952 (Electronic)
IS  - 1388-2457 (Linking)
VI  - 126
IP  - 5
DP  - 2015 May
TI  - Dissociation of functional and anatomical brain abnormalities in unaffected 
      siblings of schizophrenia patients.
PG  - 927-32
LID - S1388-2457(14)00472-6 [pii]
LID - 10.1016/j.clinph.2014.08.016 [doi]
AB  - OBJECTIVE: Schizophrenia patients and their unaffected siblings share similar 
      brain functional and structural abnormalities. However, no study is engaged to 
      investigate whether and how functional abnormalities are related to structural 
      abnormalities in unaffected siblings. This study was undertaken to examine the 
      association between functional and anatomical abnormalities in unaffected 
      siblings. METHODS: Forty-six unaffected siblings of schizophrenia patients and 46 
      age-, sex-, and education-matched healthy controls underwent structural and 
      resting-state functional magnetic resonance imaging scanning. Voxel-based 
      morphometry (VBM), amplitude of low-frequency fluctuation (ALFF) and fractional 
      ALFF (fALFF) were utilized to analyze imaging data. RESULTS: The VBM analysis 
      showed gray matter volume decreases in the fronto-temporal regions (the left 
      middle temporal gyrus and right inferior frontal gyrus, orbital part) and 
      increases in basal ganglia system (the left putamen). Functional abnormalities 
      measured by ALFF and fALFF mainly involved in the fronto-limbic-sensorimotor 
      circuit (decreased ALFF in bilateral middle frontal gyrus and the right middle 
      cingulate gyrus, and decreased fALFF in the right inferior frontal gyrus, orbital 
      part; and increased ALFF in the left fusiform gyrus and left lingual gyrus, and 
      increased fALFF in bilateral calcarine cortex). No significant correlation was 
      found between functional and anatomical abnormalities in the sibling group. 
      CONCLUSIONS: A dissociation pattern of brain regions with functional and 
      anatomical abnormalities is observed in unaffected siblings. SIGNIFICANCE: Our 
      findings suggest that brain functional and anatomical abnormalities might be 
      present independently in unaffected siblings of schizophrenia patients.
CI  - Copyright (c) 2014 International Federation of Clinical Neurophysiology. Published 
      by Elsevier Ireland Ltd. All rights reserved.
FAU - Guo, Wenbin
AU  - Guo W
AD  - Mental Health Center, The First Affiliated Hospital, Guangxi Medical University, 
      Nanning, Guangxi 530021, China. Electronic address: guowenbin76@163.com.
FAU - Song, Yan
AU  - Song Y
AD  - Mental Health Center, The First Affiliated Hospital, Guangxi Medical University, 
      Nanning, Guangxi 530021, China.
FAU - Liu, Feng
AU  - Liu F
AD  - Key Laboratory for NeuroInformation of Ministry of Education, School of Life 
      Science and Technology, University of Electronic Science and Technology of China, 
      Chengdu, Sichuan, China.
FAU - Zhang, Zhikun
AU  - Zhang Z
AD  - Mental Health Center, The First Affiliated Hospital, Guangxi Medical University, 
      Nanning, Guangxi 530021, China.
FAU - Zhang, Jian
AU  - Zhang J
AD  - Mental Health Center, The First Affiliated Hospital, Guangxi Medical University, 
      Nanning, Guangxi 530021, China.
FAU - Yu, Miaoyu
AU  - Yu M
AD  - Mental Health Center, The First Affiliated Hospital, Guangxi Medical University, 
      Nanning, Guangxi 530021, China.
FAU - Liu, Jianrong
AU  - Liu J
AD  - Mental Health Center, The First Affiliated Hospital, Guangxi Medical University, 
      Nanning, Guangxi 530021, China.
FAU - Xiao, Changqing
AU  - Xiao C
AD  - Mental Health Center, The First Affiliated Hospital, Guangxi Medical University, 
      Nanning, Guangxi 530021, China.
FAU - Liu, Guiying
AU  - Liu G
AD  - Mental Health Center, The First Affiliated Hospital, Guangxi Medical University, 
      Nanning, Guangxi 530021, China.
FAU - Zhao, Jingping
AU  - Zhao J
AD  - Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of 
      Psychiatry and Mental Health of Hunan Province, Central South University, 
      Changsha, Hunan 410011, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140906
PL  - Netherlands
TA  - Clin Neurophysiol
JT  - Clinical neurophysiology : official journal of the International Federation of 
      Clinical Neurophysiology
JID - 100883319
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain/*pathology/*physiopathology
MH  - Brain Mapping/methods
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Schizophrenia/*diagnosis/genetics/*physiopathology
MH  - *Siblings
MH  - Young Adult
OTO - NOTNLM
OT  - Amplitude of low-frequency fluctuation
OT  - Fractional amplitude of low-frequency fluctuation
OT  - Schizophrenia
OT  - Unaffected siblings
OT  - Voxel-based morphometry
EDAT- 2014/09/23 06:00
MHDA- 2015/06/16 06:00
CRDT- 2014/09/22 06:00
PHST- 2014/04/27 00:00 [received]
PHST- 2014/08/24 00:00 [revised]
PHST- 2014/08/26 00:00 [accepted]
PHST- 2014/09/22 06:00 [entrez]
PHST- 2014/09/23 06:00 [pubmed]
PHST- 2015/06/16 06:00 [medline]
AID - S1388-2457(14)00472-6 [pii]
AID - 10.1016/j.clinph.2014.08.016 [doi]
PST - ppublish
SO  - Clin Neurophysiol. 2015 May;126(5):927-32. doi: 10.1016/j.clinph.2014.08.016. 
      Epub 2014 Sep 6.