PMID- 25241288
OWN - NLM
STAT- MEDLINE
DCOM- 20150202
LR  - 20151119
IS  - 1872-8421 (Electronic)
IS  - 0165-5728 (Linking)
VI  - 276
IP  - 1-2
DP  - 2014 Nov 15
TI  - Intravenous immunoglobulin G improves neurobehavioral and histological outcomes 
      after traumatic brain injury in mice.
PG  - 112-8
LID - S0165-5728(14)00875-3 [pii]
LID - 10.1016/j.jneuroim.2014.08.626 [doi]
AB  - Intravenous immunoglobulin (IVIG) may improve neuroinflammation after traumatic 
      brain injury (TBI). IVIG administration after TBI improved rotarod latencies over 
      the first 7 days (p=0.039) and water maze latencies over 29-32 days (p=0.027), 
      decreased F4/80-positive cells at 2 (p=0.001) and 7 days (p<0.001), decreased 
      Fluoro-Jade B-positive cells (p=0.020), increased NeuN-positive cells (p=0.014), 
      decreased IL-6 production at 4 (p=0.032) and 24h (p=0.023), and decreased 
      blood-brain barrier breakdown by IgG extravasation (p=0.001) and brain edema 
      (p=0.006); however, TNF-alpha concentration was unchanged. IVIG administration was 
      associated with long-term neurobehavioral and histological improvement through 
      modulation of neuroinflammation and blood-brain barrier permeability in a murine 
      TBI model.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Jeong, Seongtae
AU  - Jeong S
AD  - Multidisciplinary Neuroprotection Laboratories, Duke University, Durham, NC, 
      United States; Department of Anesthesiology and Pain Medicine, Chonnam National 
      University Medical School, Gwangju, South Korea.
FAU - Lei, Beilei
AU  - Lei B
AD  - Multidisciplinary Neuroprotection Laboratories, Duke University, Durham, NC, 
      United States; Department of Anesthesiology, Duke University, Durham, NC, United 
      States.
FAU - Wang, Haichen
AU  - Wang H
AD  - Multidisciplinary Neuroprotection Laboratories, Duke University, Durham, NC, 
      United States; Department of Neurology, Duke University, Durham, NC, United 
      States.
FAU - Dawson, Hana N
AU  - Dawson HN
AD  - Multidisciplinary Neuroprotection Laboratories, Duke University, Durham, NC, 
      United States; Department of Neurology, Duke University, Durham, NC, United 
      States.
FAU - James, Michael L
AU  - James ML
AD  - Multidisciplinary Neuroprotection Laboratories, Duke University, Durham, NC, 
      United States; Department of Anesthesiology, Duke University, Durham, NC, United 
      States; Department of Neurology, Duke University, Durham, NC, United States. 
      Electronic address: michael.james@duke.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140906
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Antigens, Differentiation)
RN  - 0 (Fluoresceins)
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 0 (Interleukin-6)
RN  - 0 (fluoro jade)
RN  - 0 (monocyte-macrophage differentiation antigen)
RN  - EC 4.2.1.11 (Phosphopyruvate Hydratase)
SB  - IM
MH  - Animals
MH  - Antigens, Differentiation/metabolism
MH  - Blood-Brain Barrier/drug effects/physiopathology
MH  - Brain/drug effects/*metabolism
MH  - Brain Edema/drug therapy/etiology
MH  - Brain Injuries/complications/*drug therapy/*pathology
MH  - Cell Count
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Fluoresceins
MH  - Immunoglobulins, Intravenous/pharmacology/*therapeutic use
MH  - Interleukin-6/metabolism
MH  - Male
MH  - Maze Learning/*drug effects
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Microglia/drug effects/metabolism
MH  - Motor Activity/*drug effects
MH  - Phosphopyruvate Hydratase/metabolism
MH  - Reaction Time/drug effects
MH  - Time Factors
OTO - NOTNLM
OT  - Blood-brain barrier (BBB)
OT  - Intravenous immunoglobulin (IVIG)
OT  - Long-term outcome
OT  - Murine model
OT  - Neuroinflammation
OT  - Traumatic brain injury (TBI)
EDAT- 2014/09/23 06:00
MHDA- 2015/02/03 06:00
CRDT- 2014/09/22 06:00
PHST- 2014/03/21 00:00 [received]
PHST- 2014/08/25 00:00 [revised]
PHST- 2014/08/27 00:00 [accepted]
PHST- 2014/09/22 06:00 [entrez]
PHST- 2014/09/23 06:00 [pubmed]
PHST- 2015/02/03 06:00 [medline]
AID - S0165-5728(14)00875-3 [pii]
AID - 10.1016/j.jneuroim.2014.08.626 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2014 Nov 15;276(1-2):112-8. doi: 10.1016/j.jneuroim.2014.08.626. 
      Epub 2014 Sep 6.