PMID- 25241331
OWN - NLM
STAT- MEDLINE
DCOM- 20150525
LR  - 20151119
IS  - 1879-0739 (Electronic)
IS  - 0271-5317 (Linking)
VI  - 34
IP  - 9
DP  - 2014 Sep
TI  - Acanthopanax divaricatus var. chiisanensis reduces blood pressure via the 
      endothelial nitric oxide synthase pathway in the spontaneously hypertensive rat 
      model.
PG  - 797-806
LID - S0271-5317(14)00164-X [pii]
LID - 10.1016/j.nutres.2014.08.013 [doi]
AB  - In this study, we investigated the antihypertensive effects of Acanthopanax 
      divaricatus var. chiisanensis extract (AE) and its active compound, acanthoside D 
      (AD), on arterial blood pressure (BP) in vivo and endothelial function in vitro. 
      We hypothesized that AE has antihypertensive effects, which is attributed to 
      enhancement of endothelial function via the improvement of nitric oxide synthesis 
      or the angiotensin II (Ang II) response. Spontaneously hypertensive rats (SHRs) 
      and Wistar-Kyoto rats (WKYs) were randomly divided into 7 groups and then fed the 
      following diets for 14 weeks: WKY fed a normal diet (WN); SHR fed a normal diet 
      (SN); SHR fed a high-cholesterol (HC) diet (SH); SHR fed a HC diet with AE of 
      150, 300, 600 mg/kg body weight (SH-L, SH-M, SH-H); and SHR fed an HC diet with 
      AD of 600 mug/kg body weight (SH-D). Blood pressure was significantly reduced in 
      the SH-H compared with the SH from week 10 until week 14; BP was also 
      significantly decreased in the SHR fed a HC diet with AE of 300 at week 14. 
      Aortic wall thickness showed a tendency to decrease by AE and AD treatment. The 
      SH-H showed increased endothelial nitric oxide synthase (eNOS) expression in the 
      intima and media, compared with the SH. Furthermore, a significant increase in 
      intracellular nitric oxide production was induced by AE and AD treatment in human 
      umbilical vein endothelial cells. A significant increase of phospho-eNOS was 
      found with a high dose of AE in human umbilical vein endothelial cells but not 
      with AD. These results suggest that AE can regulate BP and improve endothelial 
      function via eNOS-dependent vasodilation.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Park, Soo-Yeon
AU  - Park SY
AD  - Department of Nutritional Science and Food Management, Ewha Womans University, 
      52, Ewhayeodae-gil, Seodaemun-gu, Seoul, 120-750, Republic of Korea.
FAU - Do, Gyeong-Min
AU  - Do GM
AD  - Department of Nutritional Science and Food Management, Ewha Womans University, 
      52, Ewhayeodae-gil, Seodaemun-gu, Seoul, 120-750, Republic of Korea.
FAU - Lee, Sena
AU  - Lee S
AD  - Department of Nutritional Science and Food Management, Ewha Womans University, 
      52, Ewhayeodae-gil, Seodaemun-gu, Seoul, 120-750, Republic of Korea.
FAU - Lim, Yeni
AU  - Lim Y
AD  - Department of Nutritional Science and Food Management, Ewha Womans University, 
      52, Ewhayeodae-gil, Seodaemun-gu, Seoul, 120-750, Republic of Korea.
FAU - Shin, Jae-Ho
AU  - Shin JH
AD  - Department of Biomedical Laboratory Science, Eulji University, 553, 
      Sanseong-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea.
FAU - Kwon, Oran
AU  - Kwon O
AD  - Department of Nutritional Science and Food Management, Ewha Womans University, 
      52, Ewhayeodae-gil, Seodaemun-gu, Seoul, 120-750, Republic of Korea. Electronic 
      address: orank@ewha.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140903
PL  - United States
TA  - Nutr Res
JT  - Nutrition research (New York, N.Y.)
JID - 8303331
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Furans)
RN  - 0 (Glucosides)
RN  - 0 (Lignans)
RN  - 0 (Plant Extracts)
RN  - 0 (acanthoside D)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase)
SB  - IM
MH  - Animals
MH  - Antihypertensive Agents/pharmacology/therapeutic use
MH  - Aorta
MH  - Blood Pressure/*drug effects
MH  - Eleutherococcus/*chemistry
MH  - Endothelium, Vascular/*drug effects/metabolism
MH  - Furans/pharmacology/therapeutic use
MH  - Glucosides/pharmacology/therapeutic use
MH  - Humans
MH  - Hypertension/*drug therapy/metabolism
MH  - Lignans/pharmacology/therapeutic use
MH  - Male
MH  - Nitric Oxide/*biosynthesis
MH  - Nitric Oxide Synthase/*metabolism
MH  - *Phytotherapy
MH  - Plant Extracts/pharmacology/therapeutic use
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
MH  - Signal Transduction
MH  - Umbilical Veins/cytology
MH  - Vasodilation/drug effects
OTO - NOTNLM
OT  - Acanthopanax divaricatus var. chiisanensis
OT  - Blood pressure
OT  - Endothelial function
OT  - Spontaneously hypertensive rat
OT  - eNOS
EDAT- 2014/09/23 06:00
MHDA- 2015/05/26 06:00
CRDT- 2014/09/22 06:00
PHST- 2014/03/20 00:00 [received]
PHST- 2014/08/17 00:00 [revised]
PHST- 2014/08/27 00:00 [accepted]
PHST- 2014/09/22 06:00 [entrez]
PHST- 2014/09/23 06:00 [pubmed]
PHST- 2015/05/26 06:00 [medline]
AID - S0271-5317(14)00164-X [pii]
AID - 10.1016/j.nutres.2014.08.013 [doi]
PST - ppublish
SO  - Nutr Res. 2014 Sep;34(9):797-806. doi: 10.1016/j.nutres.2014.08.013. Epub 2014 
      Sep 3.