PMID- 25241757
OWN - NLM
STAT- MEDLINE
DCOM- 20150518
LR  - 20151119
IS  - 1601-5215 (Electronic)
IS  - 0924-2708 (Linking)
VI  - 26
IP  - 5
DP  - 2014 Oct
TI  - Can BDNF and IL-2 be indicators for the diagnosis in schizophrenic patients with 
      depressive symptoms?
PG  - 291-7
LID - 10.1017/neu.2014.13 [doi]
AB  - OBJECTIVE: The aim of the current study is to determine whether serum levels of 
      brain-derived neurotrophic factor (BDNF) and interleukin-2 (IL-2) can be 
      biological indicators for the diagnosis of schizophrenia in patients with 
      depressive symptoms. METHOD: Forty-seven patients (11 patients diagnosed with 
      schizophrenia, 16 patients diagnosed with schizophrenia and comorbid depression 
      and 20 patients diagnosed with major depressive disorder) and 20 healthy subjects 
      were enrolled. The Positive and Negative Symptoms Scale, the Calgary Depression 
      Scale for Schizophrenia and the Hamilton Depression Rating Scale were used for 
      assessment. The serum BDNF and IL-2 levels of all the subjects were studied. 
      RESULTS: Decreased levels of serum BDNF and increased levels of serum IL-2 were 
      found in the patients diagnosed with either schizophrenia, schizophrenia with 
      depression, or major depressive disorder (p = 0.049, p = 0.010; p = 0.001 and p = 
      0.044; p = 0.027, p = 0.003; respectively) compared with control group. There 
      were no significant differences between the patient groups in their serum BDNF 
      and IL-2 levels. CONCLUSIONS: The present study suggests that neurotrophic 
      factors and immune system changes are involved in the pathogenesis of 
      schizophrenia with or without depressive symptomatology. However, the data do not 
      clarify whether depressive symptoms in schizophrenia occur as a dimension of 
      schizophrenia or as symptoms of major depression that is comorbid with 
      schizophrenia.
FAU - Eker, Salih Saygin
AU  - Eker SS
AD  - 1Department of Psychiatry,Uludag University Medical Faculty,Bursa,Turkey.
FAU - Yavasci, Ebru Oztepe
AU  - Yavasci EO
AD  - 1Department of Psychiatry,Uludag University Medical Faculty,Bursa,Turkey.
FAU - Cangur, Sengul
AU  - Cangur S
AD  - 2Department of Biostatistics,Duzce University Medical Faculty,Duzce,Turkey.
FAU - Kirli, Selcuk
AU  - Kirli S
AD  - 1Department of Psychiatry,Uludag University Medical Faculty,Bursa,Turkey.
FAU - Sarandol, Emre
AU  - Sarandol E
AD  - 3Department of Biochemistry,Uludag University Medical Faculty,Bursa,Turkey.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Acta Neuropsychiatr
JT  - Acta neuropsychiatrica
JID - 9612501
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Interleukin-2)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Case-Control Studies
MH  - Depressive Disorder/*blood/complications/*diagnosis
MH  - Depressive Disorder, Major/blood/complications/diagnosis
MH  - Female
MH  - Humans
MH  - Interleukin-2/*blood
MH  - Male
MH  - Middle Aged
MH  - Psychiatric Status Rating Scales
MH  - Schizophrenia/*blood/complications
EDAT- 2014/09/23 06:00
MHDA- 2015/05/20 06:00
CRDT- 2014/09/23 06:00
PHST- 2014/09/23 06:00 [entrez]
PHST- 2014/09/23 06:00 [pubmed]
PHST- 2015/05/20 06:00 [medline]
AID - S0924270814000131 [pii]
AID - 10.1017/neu.2014.13 [doi]
PST - ppublish
SO  - Acta Neuropsychiatr. 2014 Oct;26(5):291-7. doi: 10.1017/neu.2014.13.