PMID- 25242024
OWN - NLM
STAT- MEDLINE
DCOM- 20170301
LR  - 20181202
IS  - 1618-0631 (Electronic)
IS  - 0344-0338 (Linking)
VI  - 210
IP  - 11
DP  - 2014 Nov
TI  - Stem cell markers OCT4 and nestin in laryngeal squamous cell carcinoma and their 
      relation to survivin expression.
PG  - 751-8
LID - S0344-0338(14)00175-7 [pii]
LID - 10.1016/j.prp.2014.06.005 [doi]
AB  - We explored the expression of the stem cell markers OCT4 and nestin in laryngeal 
      squamous cell carcinoma (LSCC) and investigated their relationship to survivin 
      expression. Eighty-five LSCC, and 62 non-neoplastic laryngeal tissues were 
      analyzed immunohistochemically for the presence of OCT4, nestin and survivin. 
      Marker expression was correlated to clinicopathological parameters. The positive 
      detection rates of OCT4 (42.35%) and nestin (51.76%) in LSCC were higher than 
      those of non-neoplastic mucosa (p<0.05). OCT4 expression was positively 
      associated with nestin expression (p=0.0001). High expression of both OCT4 and 
      nestin was associated with higher tumor grade (p=0.0001). Also, high OCT4 
      expression was related to higher T stage (p=0.0001). Co-expression of OCT4 and 
      nestin was more significantly associated with glottic location, higher T stage 
      and nodal metastasis than high expression of either marker (p=0.015, 0.006 and 
      0.008, respectively). Survivin expression was not significantly related to 
      expression of OCT4 or nestin (p=0.094 and 0.266, respectively). OCT4 and nestin 
      are overexpressed in LSCC and may contribute to laryngeal carcinogenesis. Their 
      co-expression may help to predict the lymph node metastatic potential of LSCC. No 
      relationship was detected between expression of survivin and OCT4 or nestin.
CI  - Copyright (c) 2014 Elsevier GmbH. All rights reserved.
FAU - El Deeb, Nevine M F
AU  - El Deeb NM
AD  - Department of Pathology, Faculty of Medicine, University of Alexandria, 
      Alexandria, Egypt. Electronic address: nevineldeeb@yahoo.com.
FAU - Abdelzaher, Eman
AU  - Abdelzaher E
AD  - Department of Pathology, Faculty of Medicine, University of Alexandria, 
      Alexandria, Egypt. Electronic address: pathologisteman@yahoo.com.
LA  - eng
PT  - Journal Article
DEP - 20140619
PL  - Germany
TA  - Pathol Res Pract
JT  - Pathology, research and practice
JID - 7806109
RN  - 0 (BIRC5 protein, human)
RN  - 0 (Biomarkers)
RN  - 0 (Inhibitor of Apoptosis Proteins)
RN  - 0 (NES protein, human)
RN  - 0 (Nestin)
RN  - 0 (Octamer Transcription Factor-3)
RN  - 0 (POU5F1 protein, human)
RN  - 0 (Survivin)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/metabolism
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Female
MH  - Humans
MH  - Inhibitor of Apoptosis Proteins/*metabolism
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Lymph Nodes/pathology
MH  - Male
MH  - Middle Aged
MH  - Nestin/*metabolism
MH  - Octamer Transcription Factor-3/*metabolism
MH  - Prognosis
MH  - Stem Cells/metabolism
MH  - Survivin
OTO - NOTNLM
OT  - Laryngeal carcinoma
OT  - Nestin
OT  - OCT4
OT  - Survivin
EDAT- 2014/09/23 06:00
MHDA- 2017/03/03 06:00
CRDT- 2014/09/23 06:00
PHST- 2013/12/05 00:00 [received]
PHST- 2014/03/20 00:00 [revised]
PHST- 2014/06/10 00:00 [accepted]
PHST- 2014/09/23 06:00 [entrez]
PHST- 2014/09/23 06:00 [pubmed]
PHST- 2017/03/03 06:00 [medline]
AID - S0344-0338(14)00175-7 [pii]
AID - 10.1016/j.prp.2014.06.005 [doi]
PST - ppublish
SO  - Pathol Res Pract. 2014 Nov;210(11):751-8. doi: 10.1016/j.prp.2014.06.005. Epub 
      2014 Jun 19.