PMID- 25242361
OWN - NLM
STAT- MEDLINE
DCOM- 20150819
LR  - 20220310
IS  - 1573-2509 (Electronic)
IS  - 0920-9964 (Print)
IS  - 0920-9964 (Linking)
VI  - 159
IP  - 2-3
DP  - 2014 Nov
TI  - Symptom trajectories and psychosis onset in a clinical high-risk cohort: the 
      relevance of subthreshold thought disorder.
PG  - 278-83
LID - S0920-9964(14)00419-8 [pii]
LID - 10.1016/j.schres.2014.08.008 [doi]
AB  - BACKGROUND: Prior studies have implicated baseline positive and negative symptoms 
      as predictors of psychosis onset among individuals at clinical high risk (CHR), 
      but none have evaluated latent trajectories of symptoms over time. This study 
      evaluated the dynamic evolution of symptoms leading to psychosis onset in a CHR 
      cohort. METHOD: 100 CHR participants were assessed quarterly for up to 2.5 years. 
      Latent trajectory analysis was used to identify patterns of symptom change. 
      Logistic and proportional hazards models were employed to evaluate the predictive 
      value for psychosis onset of baseline symptoms and symptom trajectories. RESULTS: 
      Transition rate to psychosis was 26%. Disorganized communication (i.e., 
      subthreshold thought disorder) presented an increased hazard for psychosis onset, 
      both at baseline (Hazard Ratio (95% CI)=1.4 (1.1-1.9)) and as a trajectory of 
      high persistent disorganized communication (Hazard Ratio (95% CI)=2.2 (1.0-4.9)). 
      Interval clinical data did not improve the predictive value of baseline symptoms 
      for psychosis onset. CONCLUSIONS: High baseline disorganized communication 
      evident at ascertainment tended to persist and lead to psychosis onset, 
      consistent with prior behavioral and speech analysis studies in similar cohorts. 
      Remediation of language dysfunction therefore may be a candidate strategy for 
      preventive intervention.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - DeVylder, Jordan E
AU  - DeVylder JE
AD  - New York State Psychiatric Institute at Columbia University, 1051 Riverside 
      Drive, New York, NY, USA; Columbia University School of Social Work, New York, 
      NY, USA. Electronic address: jdevylder@ssw.umaryland.edu.
FAU - Muchomba, Felix M
AU  - Muchomba FM
AD  - Columbia University School of Social Work, New York, NY, USA. Electronic address: 
      Fmm2116@columbia.edu.
FAU - Gill, Kelly E
AU  - Gill KE
AD  - New York State Psychiatric Institute at Columbia University, 1051 Riverside 
      Drive, New York, NY, USA. Electronic address: Kegill13@gmail.com.
FAU - Ben-David, Shelly
AU  - Ben-David S
AD  - New York State Psychiatric Institute at Columbia University, 1051 Riverside 
      Drive, New York, NY, USA. Electronic address: shellybendavid@gmail.com.
FAU - Walder, Deborah J
AU  - Walder DJ
AD  - Brooklyn College, Department of Psychology, Brooklyn, NY, USA; The Graduate 
      Center of the City University of NY (CUNY), New York, NY USA. Electronic address: 
      DWalder@brooklyn.cuny.edu.
FAU - Malaspina, Dolores
AU  - Malaspina D
AD  - Creedmoor Psychiatric Center, New York Office of Mental Health, New York, NY, 
      USA; NYU Department of Psychiatry, New York, NY, USA. Electronic address: 
      Dolores.malaspina@nyumc.org.
FAU - Corcoran, Cheryl M
AU  - Corcoran CM
AD  - New York State Psychiatric Institute at Columbia University, 1051 Riverside 
      Drive, New York, NY, USA. Electronic address: corcora@nyspi.columbia.edu.
LA  - eng
GR  - R21MH086125/MH/NIMH NIH HHS/United States
GR  - R01P50MH086385/MH/NIMH NIH HHS/United States
GR  - K23MH066279/MH/NIMH NIH HHS/United States
GR  - UL1 RR024156/RR/NCRR NIH HHS/United States
GR  - K23 MH066279/MH/NIMH NIH HHS/United States
GR  - UL1 TR000040/TR/NCATS NIH HHS/United States
GR  - R21 MH086125/MH/NIMH NIH HHS/United States
GR  - P50 MH086385/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20140919
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cohort Studies
MH  - Communication Disorders/*etiology
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Male
MH  - Psychiatric Status Rating Scales
MH  - Psychotic Disorders/*diagnosis/*physiopathology
MH  - ROC Curve
MH  - Statistics as Topic
MH  - Survival Analysis
MH  - Time Factors
MH  - Young Adult
PMC - PMC4254175
MID - NIHMS624577
OTO - NOTNLM
OT  - Clinical high risk
OT  - Disorganized communication
OT  - Latent trajectory analysis
OT  - Longitudinal
OT  - Schizophrenia
OT  - Ultra high risk
COIS- Conflict of Interest None.
EDAT- 2014/09/23 06:00
MHDA- 2015/08/20 06:00
PMCR- 2015/11/01
CRDT- 2014/09/23 06:00
PHST- 2014/06/13 00:00 [received]
PHST- 2014/08/03 00:00 [revised]
PHST- 2014/08/06 00:00 [accepted]
PHST- 2014/09/23 06:00 [entrez]
PHST- 2014/09/23 06:00 [pubmed]
PHST- 2015/08/20 06:00 [medline]
PHST- 2015/11/01 00:00 [pmc-release]
AID - S0920-9964(14)00419-8 [pii]
AID - 10.1016/j.schres.2014.08.008 [doi]
PST - ppublish
SO  - Schizophr Res. 2014 Nov;159(2-3):278-83. doi: 10.1016/j.schres.2014.08.008. Epub 
      2014 Sep 19.