PMID- 25243504
OWN - NLM
STAT- MEDLINE
DCOM- 20150122
LR  - 20141022
IS  - 0026-4946 (Print)
IS  - 0026-4946 (Linking)
VI  - 66
IP  - 6
DP  - 2014 Dec
TI  - Endocrine cancer syndromes: an update.
PG  - 533-47
AB  - Endocrine neoplasms comprise a variety of benign and malign tumors that arise 
      from the endocrine glands or neuroendocrine tissues. Although most endocrine 
      neoplasms are sporadic, others are secondary to mutations of many known 
      tumor-predisposing genes. Endocrine cancer syndromes, including Multiple 
      Endocrine Neoplasia type 1 (MEN1), Multiple Endocrine Neoplasia type 2 (MEN2A and 
      MEN2B), Multiple Endocrine Neoplasia type 4 (MEN4) syndromes, and inherited 
      syndromes with different endocrine neoplasms (von Hippel-Lindau disease, Carney 
      complex, Neurofibromatosis type 1, others) are heterogeneous group of cancer 
      susceptibility syndromes that affect one or more of the endocrine glands or 
      neuroendocrine tissues. Genetic studies and researches as well as technological 
      possibilities allowed for detection of new endocrine cancer syndromes and genes 
      leading to tumor susceptibility. In addition, early detection of children at risk 
      for endocrine cancer syndromes using molecular analysis methods provided 
      opportunity to regular monitoring of potential malignancies and timely 
      intervention for these cases (e.g. early prophylactic thyroidectomy in MEN2). 
      This review will describe the clinical, genetic, diagnostic and therapeutic 
      options for endocrine cancer syndromes based on the current literature data.
FAU - Anik, A
AU  - Anik A
AD  - Dokuz Eylul University Department of Pediatric Endocrinology Izmir, Turkey - 
      ayhanabaci@gmail.com.
FAU - Abaci, A
AU  - Abaci A
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140922
PL  - Italy
TA  - Minerva Pediatr
JT  - Minerva pediatrica
JID - 0400740
SB  - IM
MH  - Early Detection of Cancer
MH  - Endocrine Gland Neoplasms/diagnosis/*pathology/therapy
MH  - Genetic Predisposition to Disease
MH  - Genetic Testing/methods
MH  - Humans
MH  - Molecular Diagnostic Techniques
MH  - Multiple Endocrine Neoplasia/diagnosis/*pathology/therapy
MH  - Mutation
MH  - Neoplastic Syndromes, Hereditary/diagnosis/pathology/therapy
MH  - Neuroendocrine Tumors/diagnosis/*pathology/therapy
EDAT- 2014/09/23 06:00
MHDA- 2015/01/23 06:00
CRDT- 2014/09/23 06:00
PHST- 2014/09/23 06:00 [entrez]
PHST- 2014/09/23 06:00 [pubmed]
PHST- 2015/01/23 06:00 [medline]
AID - R15Y9999N00A140027 [pii]
PST - ppublish
SO  - Minerva Pediatr. 2014 Dec;66(6):533-47. Epub 2014 Sep 22.