PMID- 25244167
OWN - NLM
STAT- MEDLINE
DCOM- 20150521
LR  - 20140923
IS  - 1087-2108 (Electronic)
IS  - 1087-2108 (Linking)
VI  - 20
IP  - 9
DP  - 2014 Sep 16
TI  - Incidental angiofibromas prompt a diagnosis of multiple endocrine neoplasia 
      type-1 (MEN-1).
LID - 13030/qt4kq2z97b [pii]
AB  - IMPORTANCE: We believe this to be the first documented report of multiple 
      endocrine neoplasia type-1 (MEN-1) in which the diagnosis was suspected based 
      purely on cutaneous findings. The patient was initially referred to the 
      dermatology department for cosmetic concerns and had no overt symptoms, 
      laboratory abnormalities, or known family history of MEN-1. OBSERVATIONS: The 
      patient is a 28-year-old man who was referred to the dermatology department for 
      evaluation and removal of skins lesions, later confirmed by biopsy to be facial 
      angiofibromas and a truncal collagenoma. This combination of cutaneous findings 
      was suspicious for a genodermatosis and genetic testing subsequently confirmed 
      the diagnosis of MEN-1. The patient was referred for appropriate follow up and 
      surveillance. CONCLUSIONS AND RELEVANCE: This case highlights the importance of 
      vigilance on the part of dermatologists to be aware of subtle skin findings that 
      may be characteristic of rare disorders and may have gone unrecognized by other 
      providers and the patients themselves. In this respect, dermatologists are in a 
      unique position given their specialized training in the recognition of inherited 
      skin disorders. An early diagnosis of an inherited disorder, especially one with 
      increased risk of malignancy, can allow for appropriate surveillance and 
      potentially alter the course of the disease.
FAU - Roman, John W
AU  - Roman JW
AD  - 3d Marine Division, at Camp Schwab, Okinawa, Japan.
FAU - Logemann, Nicholas F
AU  - Logemann NF
FAU - Adams, Erin
AU  - Adams E
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20140916
PL  - United States
TA  - Dermatol Online J
JT  - Dermatology online journal
JID - 9610776
SB  - IM
MH  - Adult
MH  - Angiofibroma/*diagnosis
MH  - Early Diagnosis
MH  - Facial Neoplasms/*diagnosis
MH  - Humans
MH  - Male
MH  - Multiple Endocrine Neoplasia Type 1/*diagnosis
MH  - Neoplasms, Multiple Primary/*diagnosis
EDAT- 2014/09/23 06:00
MHDA- 2015/05/23 06:00
CRDT- 2014/09/23 06:00
PHST- 2014/09/16 00:00 [received]
PHST- 2014/09/16 00:00 [accepted]
PHST- 2014/09/23 06:00 [entrez]
PHST- 2014/09/23 06:00 [pubmed]
PHST- 2015/05/23 06:00 [medline]
AID - 13030/qt4kq2z97b [pii]
PST - epublish
SO  - Dermatol Online J. 2014 Sep 16;20(9):13030/qt4kq2z97b.