PMID- 2524436
OWN - NLM
STAT- MEDLINE
DCOM- 19890713
LR  - 20061115
IS  - 0016-254X (Print)
IS  - 0016-254X (Linking)
VI  - 80
IP  - 1
DP  - 1989 Jan
TI  - [Immunogenetic analysis of Cryptomeria pollinosis. Evidence for the HLA-linked 
      immune suppression gene to Cryptomeria japonica pollen antigen].
PG  - 28-37
AB  - The IgE response to Cryptomeria japonica pollen antigen (CPAg) in vivo was 
      measured by radioimmunoassay, using plasma from 525 members of 98 families. 1) 
      The 525 were classified into non plus low (non/low) responder group and high 
      responder group. 2) Segregation analysis revealed that the non/low responsiveness 
      to CPAg was formally a single dominant trait. 3) The frequency of this gene 
      mediated for non/low responsiveness to CPAg was calculated to be 0.44-0.60. 4) 
      Linkage analysis revealed that the gene controlling non/low responsiveness to 
      CPAg is linked to human leukocyte antigen (HLA) with a maximum lod score, 3.40 at 
      theta = 0.18. 5) Non/low responders' macrophage could present CPAg to B.T cell of 
      high responders in an HLA-DR-shared combination. A foregoing study demonstrated 
      that HLA-DR molecule function as a product of Ir-gene for CPAg and that the 
      non/low response to CPAg was mediated by CPAg-specific suppressor T cells. Taken 
      together, these observations clearly demonstrated that the non/low responsiveness 
      to CPAg is not due to the defect of Ir-gene, but rather is mediated by the 
      HLA-linked immune suppression gene for CPAg (Is-CPAg), through CPAg-specific 
      suppressor T cells. This is the second report for HLA-linked Is-gene in humans.
FAU - Honda, K
AU  - Honda K
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Fukuoka Igaku Zasshi
JT  - Fukuoka igaku zasshi = Hukuoka acta medica
JID - 9423321
RN  - 0 (HLA Antigens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Female
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - Immunoglobulin E/analysis
MH  - Lod Score
MH  - Male
MH  - Pollen/*immunology
MH  - Rhinitis, Allergic, Seasonal/*genetics
MH  - *Suppression, Genetic
MH  - T-Lymphocytes, Regulatory
EDAT- 1989/01/01 00:00
MHDA- 1989/01/01 00:01
CRDT- 1989/01/01 00:00
PHST- 1989/01/01 00:00 [pubmed]
PHST- 1989/01/01 00:01 [medline]
PHST- 1989/01/01 00:00 [entrez]
PST - ppublish
SO  - Fukuoka Igaku Zasshi. 1989 Jan;80(1):28-37.