PMID- 25244865
OWN - NLM
STAT- MEDLINE
DCOM- 20150615
LR  - 20181202
IS  - 0250-3301 (Print)
IS  - 0250-3301 (Linking)
VI  - 35
IP  - 7
DP  - 2014 Jul
TI  - [Toxicity of three chlorophenols to protozoa Tetrahymena thermophila].
PG  - 2755-61
AB  - Using Tetrahymena thermophila as the indication organism, the single acute 
      toxicity and genotoxicity induced by 2,4-dichlorophenol (2,4-DCP), 
      2,4,6-trichlorophenol (2,4,6-TCP) and pentachlorophenol (PCP) were determined. 
      The results showed that the 24, 48, 72 and 96-hour EC50 values of 3 individual 
      CPs to T. thermophila were 3.69, 3.54, 3.02, 2.34 mg x L(-1); 3.23, 2.83, 2.56, 
      1.97 mg x L(-1) and 0.63, 0.45, 0.34, 0.28 mg x L(-1), respectively, which 
      revealed that the acute toxicity of CPs increased with the number of chlorine on 
      benzene ring. Effects of water hardness on the acute toxicities of 2,4-DCP, 
      2,4,6-TCP and PCP to T. thermophila were evaluated. It showed that the effect of 
      water hardness on the acute toxicities of the three CPs to T. thermophila had a 
      certain influence, but the impact was relatively insignificant. The results in 
      the SCGE showed that there were significant differences (P < 0.05) between the 
      control and treatment groups at various concentrations of the three CPs. It 
      recommended that the comet assay of T. thermophila was sensitive to the three 
      detected CPs and could be a useful tool for screening and detecting of 
      environmental genotoxins.
FAU - Li, Ya-Jie
AU  - Li YJ
FAU - Cui, Yi-Bin
AU  - Cui YB
FAU - Jiang, Li-Juan
AU  - Jiang LJ
FAU - Dou, Jing
AU  - Dou J
FAU - Li, Mei
AU  - Li M
LA  - chi
PT  - Journal Article
PL  - China
TA  - Huan Jing Ke Xue
JT  - Huan jing ke xue= Huanjing kexue
JID - 8405344
RN  - 0 (Chlorophenols)
RN  - D9BSU0SE4T (Pentachlorophenol)
RN  - MHS8C5BAUZ (2,4,6-trichlorophenol)
RN  - R669TG1950 (2,4-dichlorophenol)
SB  - IM
MH  - Animals
MH  - Chlorophenols/*toxicity
MH  - Comet Assay
MH  - *Environmental Monitoring
MH  - Pentachlorophenol/*toxicity
MH  - Tetrahymena thermophila/*drug effects
EDAT- 2014/09/24 06:00
MHDA- 2015/06/16 06:00
CRDT- 2014/09/24 06:00
PHST- 2014/09/24 06:00 [entrez]
PHST- 2014/09/24 06:00 [pubmed]
PHST- 2015/06/16 06:00 [medline]
PST - ppublish
SO  - Huan Jing Ke Xue. 2014 Jul;35(7):2755-61.