PMID- 25244975
OWN - NLM
STAT- MEDLINE
DCOM- 20150202
LR  - 20220331
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Linking)
VI  - 159
IP  - 1
DP  - 2015 Jan
TI  - Choroidal findings in dome-shaped macula in highly myopic eyes: a longitudinal 
      study.
PG  - 44-52
LID - S0002-9394(14)00616-3 [pii]
LID - 10.1016/j.ajo.2014.09.026 [doi]
AB  - PURPOSE: To describe choroidal findings in dome-shaped macula associated with 
      high myopia using fluorescein angiography (FA), indocyanine green angiography 
      (ICGA), and spectral-domain optical coherence tomography (SD OCT), and to 
      elucidate the mechanism and natural course of serous retinal detachment (RD) 
      associated with dome-shaped macula. DESIGN: Retrospective, observational case 
      series. METHODS: We reviewed longitudinal imaging results of 52 highly myopic 
      eyes with dome-shaped macula. Changes on FA and ICGA were assessed. Retinal, 
      choroidal, and scleral thicknesses and bulge height were measured on SD OCT. 
      RESULTS: Serous RD was the most common abnormality associated with dome-shaped 
      macula, detected by SD OCT in 44% of the cases with no associated choroidal 
      neovascularization. Significant differences in the proportion of eyes with 
      pinpoint leakage on FA (P < .001), punctate hypercyanescence on ICGA (P < .001), 
      and pigment epithelium detachment on SD OCT (P < .001) were noted inside the 
      inward bulge of the staphyloma between eyes with and without serous RD. Serous RD 
      was not associated with hyperpermeability areas on ICGA. Eyes with serous RD had 
      thicker choroid (P = .004) and tended to have thicker sclera (P = .067) and 
      greater bulge height (P = .079). Choroidal thickness, scleral thickness, and 
      bulge height were positively correlated (P < .01). All eyes presented a 
      fluctuating course of serous RD during follow-up. Worsening of serous RD was 
      associated with appearance of new punctate hypercyanescent spots on ICGA and 
      leaking points on FA (P < .001 and P = .016, respectively). CONCLUSION: Serous RD 
      in dome-shaped macula was likely caused by choroidal vascular changes, similar to 
      central serous chorioretinopathy, but specifically confined in the inward bulge 
      of the staphyloma and secondary to excessive scleral thickening. Serous retinal 
      detachment showed fluctuating changes over time, with alternating active and 
      inactive stages. Angiographic findings in dome-shaped macula suggest the choroid 
      as a target for possible treatment strategies.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Viola, Francesco
AU  - Viola F
AD  - Ophthalmological Unit, Ca' Granda Foundation-Ospedale Maggiore Policlinico, 
      University of Milan, Department of Clinical Sciences and Community Health, Milan, 
      Italy. Electronic address: francesco.viola@unimi.it.
FAU - Dell'Arti, Laura
AU  - Dell'Arti L
AD  - Ophthalmological Unit, Ca' Granda Foundation-Ospedale Maggiore Policlinico, 
      University of Milan, Department of Clinical Sciences and Community Health, Milan, 
      Italy.
FAU - Benatti, Eleonora
AU  - Benatti E
AD  - Ophthalmological Unit, Ca' Granda Foundation-Ospedale Maggiore Policlinico, 
      University of Milan, Department of Clinical Sciences and Community Health, Milan, 
      Italy.
FAU - Invernizzi, Alessandro
AU  - Invernizzi A
AD  - Ophthalmological Unit, Ca' Granda Foundation-Ospedale Maggiore Policlinico, 
      University of Milan, Department of Clinical Sciences and Community Health, Milan, 
      Italy; Eye Clinic, Department of Biomedical and Clinical Sciences "Luigi Sacco," 
      Luigi Sacco Hospital, University of Milan, Milan, Italy.
FAU - Mapelli, Chiara
AU  - Mapelli C
AD  - Ophthalmological Unit, Ca' Granda Foundation-Ospedale Maggiore Policlinico, 
      University of Milan, Department of Clinical Sciences and Community Health, Milan, 
      Italy.
FAU - Ferrari, Fabio
AU  - Ferrari F
AD  - Ophthalmological Unit, Ca' Granda Foundation-Ospedale Maggiore Policlinico, 
      University of Milan, Department of Clinical Sciences and Community Health, Milan, 
      Italy.
FAU - Ratiglia, Roberto
AU  - Ratiglia R
AD  - Ophthalmological Unit, Ca' Granda Foundation-Ospedale Maggiore Policlinico, 
      University of Milan, Department of Clinical Sciences and Community Health, Milan, 
      Italy.
FAU - Staurenghi, Giovanni
AU  - Staurenghi G
AD  - Eye Clinic, Department of Biomedical and Clinical Sciences "Luigi Sacco," Luigi 
      Sacco Hospital, University of Milan, Milan, Italy.
FAU - Barteselli, Giulio
AU  - Barteselli G
AD  - Ophthalmological Unit, Ca' Granda Foundation-Ospedale Maggiore Policlinico, 
      University of Milan, Department of Clinical Sciences and Community Health, Milan, 
      Italy.
LA  - eng
PT  - Journal Article
DEP - 20140922
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
RN  - 0 (Coloring Agents)
RN  - IX6J1063HV (Indocyanine Green)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Choroid/pathology
MH  - Coloring Agents
MH  - Female
MH  - Fluorescein Angiography
MH  - Humans
MH  - Indocyanine Green
MH  - Longitudinal Studies
MH  - Macula Lutea/*pathology
MH  - Male
MH  - Middle Aged
MH  - Myopia/*diagnosis
MH  - Retinal Detachment/*diagnosis
MH  - Retinal Pigment Epithelium/pathology
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence/methods
MH  - Young Adult
EDAT- 2014/09/24 06:00
MHDA- 2015/02/03 06:00
CRDT- 2014/09/24 06:00
PHST- 2014/05/20 00:00 [received]
PHST- 2014/09/13 00:00 [revised]
PHST- 2014/09/16 00:00 [accepted]
PHST- 2014/09/24 06:00 [entrez]
PHST- 2014/09/24 06:00 [pubmed]
PHST- 2015/02/03 06:00 [medline]
AID - S0002-9394(14)00616-3 [pii]
AID - 10.1016/j.ajo.2014.09.026 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2015 Jan;159(1):44-52. doi: 10.1016/j.ajo.2014.09.026. Epub 2014 
      Sep 22.