PMID- 25245013
OWN - NLM
STAT- MEDLINE
DCOM- 20150805
LR  - 20141216
IS  - 1878-3279 (Electronic)
IS  - 0171-2985 (Linking)
VI  - 220
IP  - 2
DP  - 2015 Feb
TI  - Mode of dendritic cell activation: the decisive hand in Th2/Th17 cell 
      differentiation. Implications in asthma severity?
PG  - 254-61
LID - S0171-2985(14)00177-6 [pii]
LID - 10.1016/j.imbio.2014.09.016 [doi]
AB  - Asthma is a heterogeneous chronic inflammatory disease of the airways, with 
      reversible airflow limitations and airway remodeling. The classification of 
      asthma phenotypes was initially based on different combinations of clinical 
      symptoms, but they are now unfolding to link biology to phenotype. As such, 
      patients can suffer from a predominant eosinophilic, neutrophilic or even mixed 
      eosinophilic/neutrophilic inflammatory response. In adult asthma patients, 
      eosinophilic inflammation is usually seen in mild-to-moderate disease and 
      neutrophilic inflammation in more severe disease. The underlying T cell response 
      is predominated by T helper (Th) 2, Th17, or a mixed Th2/Th17 cell immune 
      response. Dendritic cells (DCs) are "professional" antigen presenting cells 
      (APCs), since their principal function is to present antigens and induce a 
      primary immune response in resting naive T cells. DCs also drive the 
      differentiation into distinctive Th subsets. The expression of co-stimulatory 
      molecules and cytokines by DCs and surrounding cells determines the outcome of Th 
      cell differentiation. The nature of DC activation will determine the expression 
      of specific co-stimulatory molecules and cytokines, specifically needed for 
      induction of the different Th cell programs. Thus DC activation is crucial for 
      the subsequent effector Th immune responses. In this review, we will discuss 
      underlying mechanisms that initiate DC activation in favor of Th2 differentiation 
      versus Th1/Th17 and Th17 differentiation in the development of mild versus 
      moderate to severe asthma.
CI  - Copyright (c) 2014 Elsevier GmbH. All rights reserved.
FAU - Vroman, Heleen
AU  - Vroman H
AD  - Department of Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands.
FAU - van den Blink, Bernt
AU  - van den Blink B
AD  - Department of Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands.
FAU - Kool, Mirjam
AU  - Kool M
AD  - Department of Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands. 
      Electronic address: m.kool@erasmusmc.nl.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140916
PL  - Netherlands
TA  - Immunobiology
JT  - Immunobiology
JID - 8002742
RN  - 0 (Antigens)
SB  - IM
MH  - Animals
MH  - Antigen Presentation/immunology
MH  - Antigens/immunology
MH  - Asthma/immunology/metabolism
MH  - Cell Communication/immunology
MH  - Cell Differentiation
MH  - Dendritic Cells/*immunology/*metabolism
MH  - Humans
MH  - Lung/immunology/metabolism
MH  - Lymphocyte Activation/immunology
MH  - Phenotype
MH  - Pyroglyphidae/immunology
MH  - Signal Transduction
MH  - Th17 Cells/cytology/immunology/metabolism
MH  - Th2 Cells/cytology/immunology/metabolism
OTO - NOTNLM
OT  - Asthma
OT  - Dendritic cells
OT  - Eosinophils
OT  - Neutrophils
OT  - T helper 17 cells
OT  - T helper 2 cells
EDAT- 2014/09/24 06:00
MHDA- 2015/08/06 06:00
CRDT- 2014/09/24 06:00
PHST- 2014/05/16 00:00 [received]
PHST- 2014/08/12 00:00 [revised]
PHST- 2014/09/05 00:00 [accepted]
PHST- 2014/09/24 06:00 [entrez]
PHST- 2014/09/24 06:00 [pubmed]
PHST- 2015/08/06 06:00 [medline]
AID - S0171-2985(14)00177-6 [pii]
AID - 10.1016/j.imbio.2014.09.016 [doi]
PST - ppublish
SO  - Immunobiology. 2015 Feb;220(2):254-61. doi: 10.1016/j.imbio.2014.09.016. Epub 
      2014 Sep 16.