PMID- 25246336 OWN - NLM STAT- MEDLINE DCOM- 20150127 LR - 20151119 IS - 1365-229X (Electronic) IS - 0009-9260 (Linking) VI - 69 IP - 12 DP - 2014 Dec TI - MRI findings of radiation-induced myocardial damage in patients with oesophageal cancer. PG - 1273-9 LID - S0009-9260(14)00402-4 [pii] LID - 10.1016/j.crad.2014.08.010 [doi] AB - AIM: To evaluate radiation-induced myocardial damage after mediastinal radiotherapy using MRI. MATERIALS AND METHODS: Between May 2010 and April 2011, delayed contrast-enhanced MRI was performed for patients who had maintained a complete response to curative radiotherapy for oesophageal cancer for more than 6 months. The patients received radiotherapy with a median total dose of 66 Gy (60-70 Gy) for the primary tumour and metastatic lymph nodes. Images of MRI were analysed by a 17-segment method recommended by the American Heart Association. A segment included mainly in the 40 Gy dose line was defined as Segment 40 Gy, a segment included mainly in the 60 Gy dose line as Segment 60 Gy, and a segment out of the radiation fields as Segment OUT. The percentage of late gadolinium enhancement (LGE) was examined in those categories. The layer in which LGE was predominantly distributed was evaluated for each patient. RESULTS: Four hundred and eight segments in 24 patients were analysed. The median interval from completion of radiotherapy to MRI was 23.5 months (range 6-88 months). LGE was detected in 12 of the 24 patients. LGE was detected in 15.38% of Segment 40 Gy cases, 21.21% of Segment 60 Gy cases, and 0% of Segment OUT cases. LGE in mid-myocardial and subendocardial layers was detected in 11 patients and one patient, respectively. CONCLUSION: LGE suggesting radiation induced myocardial fibrosis was observed by performing delayed contrast-enhanced MRI. Care should be taken when planning radiotherapy to avoid late cardiac damage. CI - Copyright (c) 2014 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved. FAU - Umezawa, R AU - Umezawa R AD - Department of Radiation Oncology, Tohoku University School of Medicine, Sendai, Japan. Electronic address: reirei513@hotmail.com. FAU - Ota, H AU - Ota H AD - Department of Diagnostic Radiology, Tohoku University School of Medicine, Sendai, Japan. FAU - Takanami, K AU - Takanami K AD - Department of Diagnostic Radiology, Tohoku University School of Medicine, Sendai, Japan. FAU - Ichinose, A AU - Ichinose A AD - Department of Diagnostic Radiology, Tohoku University School of Medicine, Sendai, Japan. FAU - Matsushita, H AU - Matsushita H AD - Department of Radiation Oncology, Tohoku University School of Medicine, Sendai, Japan. FAU - Saito, H AU - Saito H AD - Department of Diagnostic Image Analysis, Tohoku University Graduate School of Medicine, Sendai, Japan. FAU - Takase, K AU - Takase K AD - Department of Diagnostic Radiology, Tohoku University School of Medicine, Sendai, Japan. FAU - Jingu, K AU - Jingu K AD - Department of Radiation Oncology, Tohoku University School of Medicine, Sendai, Japan. LA - eng PT - Journal Article DEP - 20140920 PL - England TA - Clin Radiol JT - Clinical radiology JID - 1306016 RN - 0 (Contrast Media) RN - AU0V1LM3JT (Gadolinium) SB - IM CIN - Clin Radiol. 2015 Jun;70(6):676-7. PMID: 25626626 MH - Aged MH - Cardiomyopathies/*etiology/*pathology MH - Contrast Media MH - Esophageal Neoplasms/complications/*radiotherapy MH - Female MH - Gadolinium MH - Heart/*radiation effects MH - Humans MH - Image Enhancement/methods MH - Magnetic Resonance Imaging/*methods MH - Male MH - Myocardium/*pathology MH - Radiation Injuries/*complications MH - Radiotherapy/adverse effects MH - Radiotherapy Dosage MH - Reproducibility of Results MH - Tomography, X-Ray Computed/methods EDAT- 2014/09/24 06:00 MHDA- 2015/01/28 06:00 CRDT- 2014/09/24 06:00 PHST- 2014/06/21 00:00 [received] PHST- 2014/06/21 00:00 [revised] PHST- 2014/08/12 00:00 [accepted] PHST- 2014/09/24 06:00 [entrez] PHST- 2014/09/24 06:00 [pubmed] PHST- 2015/01/28 06:00 [medline] AID - S0009-9260(14)00402-4 [pii] AID - 10.1016/j.crad.2014.08.010 [doi] PST - ppublish SO - Clin Radiol. 2014 Dec;69(12):1273-9. doi: 10.1016/j.crad.2014.08.010. Epub 2014 Sep 20.