PMID- 25246352
OWN - NLM
STAT- MEDLINE
DCOM- 20150605
LR  - 20201114
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 583
DP  - 2014 Nov 7
TI  - Nociceptive sensitization and BDNF up-regulation in a rat model of traumatic 
      brain injury.
PG  - 55-9
LID - S0304-3940(14)00767-8 [pii]
LID - 10.1016/j.neulet.2014.09.030 [doi]
AB  - Chronic pain after traumatic brain injury (TBI) is very common, but the 
      mechanisms linking TBI to pain experienced in the periphery have not been 
      described. In this set of studies we examined nociceptive sensitization and 
      changes in spinal cord gene expression using the rat lateral fluid percussion 
      model of mild TBI. We did not identify changes in thermal nociceptive thresholds 
      in rats with mild TBI. However, mechanical allodynia in hind paws contralateral 
      to TBI was significant and sustained. We also found that spinal cord levels of 
      brain derived neurotrophic factor (BDNF) but not several other pain-related genes 
      were up-regulated one week after injury. Our findings suggest that TBI-induced 
      up-regulation of spinal BDNF levels might contribute to chronic TBI-related pain, 
      and that the lateral fluid percussion model might be useful for exploring this 
      relationship.
CI  - Published by Elsevier Ireland Ltd.
FAU - Feliciano, David P
AU  - Feliciano DP
AD  - Department of Anesthesiology Perioperative and Pain Medicine, 291 Campus Drive, 
      Stanford, CA 94305, United States.
FAU - Sahbaie, Peyman
AU  - Sahbaie P
AD  - Anesthesiology Service, VA Palo Alto Healthcare System, 3801 Miranda Avenue, Palo 
      Alto, CA 94304, United States.
FAU - Shi, Xiaoyou
AU  - Shi X
AD  - Department of Anesthesiology Perioperative and Pain Medicine, 291 Campus Drive, 
      Stanford, CA 94305, United States; Anesthesiology Service, VA Palo Alto 
      Healthcare System, 3801 Miranda Avenue, Palo Alto, CA 94304, United States.
FAU - Klukinov, Michael
AU  - Klukinov M
AD  - Department of Anesthesiology Perioperative and Pain Medicine, 291 Campus Drive, 
      Stanford, CA 94305, United States.
FAU - Clark, J David
AU  - Clark JD
AD  - Department of Anesthesiology Perioperative and Pain Medicine, 291 Campus Drive, 
      Stanford, CA 94305, United States; Anesthesiology Service, VA Palo Alto 
      Healthcare System, 3801 Miranda Avenue, Palo Alto, CA 94304, United States. 
      Electronic address: djclark@stanford.edu.
FAU - Yeomans, David C
AU  - Yeomans DC
AD  - Department of Anesthesiology Perioperative and Pain Medicine, 291 Campus Drive, 
      Stanford, CA 94305, United States.
LA  - eng
PT  - Journal Article
DEP - 20140920
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain Injuries/*metabolism/*physiopathology/psychology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Gene Expression
MH  - Male
MH  - *Nociception
MH  - Rats, Sprague-Dawley
MH  - Up-Regulation
OTO - NOTNLM
OT  - Brain derived neurotrophic factor
OT  - Chronic pain
OT  - Traumatic brain injury
EDAT- 2014/09/24 06:00
MHDA- 2015/06/06 06:00
CRDT- 2014/09/24 06:00
PHST- 2014/08/07 00:00 [received]
PHST- 2014/09/09 00:00 [revised]
PHST- 2014/09/11 00:00 [accepted]
PHST- 2014/09/24 06:00 [entrez]
PHST- 2014/09/24 06:00 [pubmed]
PHST- 2015/06/06 06:00 [medline]
AID - S0304-3940(14)00767-8 [pii]
AID - 10.1016/j.neulet.2014.09.030 [doi]
PST - ppublish
SO  - Neurosci Lett. 2014 Nov 7;583:55-9. doi: 10.1016/j.neulet.2014.09.030. Epub 2014 
      Sep 20.