PMID- 25246496
OWN - NLM
STAT- MEDLINE
DCOM- 20150303
LR  - 20211203
IS  - 1550-6606 (Electronic)
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 193
IP  - 9
DP  - 2014 Nov 1
TI  - Human CD141+ dendritic cells induce CD4+ T cells to produce type 2 cytokines.
PG  - 4335-43
LID - 10.4049/jimmunol.1401159 [doi]
AB  - Dendritic cells (DCs) play the central role in the priming of naive T cells and 
      the differentiation of unique effector T cells. In this study, using lung tissues 
      and blood from both humans and humanized mice, we analyzed the response of human 
      CD1c(+) and CD141(+) DC subsets to live-attenuated influenza virus. Specifically, 
      we analyzed the type of CD4(+) T cell immunity elicited by live-attenuated 
      influenza virus-exposed DCs. Both DC subsets induce proliferation of allogeneic 
      naive CD4(+) T cells with the capacity to secrete IFN-gamma. However, CD141(+) DCs 
      are uniquely able to induce the differentiation of IL-4- and IL-13-producing 
      CD4(+) T cells. CD141(+) DCs induce IL-4- and IL-13-secreting CD4(+) T cells 
      through OX40 ligand. Thus, CD141(+) DCs demonstrate remarkable plasticity in 
      guiding adaptive immune responses.
CI  - Copyright (c) 2014 by The American Association of Immunologists, Inc.
FAU - Yu, Chun I
AU  - Yu CI
AD  - Baylor Institute for Immunology Research, Dallas, TX 75204;
FAU - Becker, Christian
AU  - Becker C
AD  - Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, 
      Mount Sinai School of Medicine, New York, NY 10029; Immunology Institute, Mount 
      Sinai School of Medicine, New York, NY 10029;
FAU - Metang, Patrick
AU  - Metang P
AD  - Baylor Institute for Immunology Research, Dallas, TX 75204;
FAU - Marches, Florentina
AU  - Marches F
AD  - Baylor Institute for Immunology Research, Dallas, TX 75204;
FAU - Wang, Yuanyuan
AU  - Wang Y
AD  - Baylor Institute for Immunology Research, Dallas, TX 75204; Institute of 
      Biomedical Studies, Baylor University, Waco, TX 76798;
FAU - Toshiyuki, Hori
AU  - Toshiyuki H
AD  - College of Life Sciences, Ritsumeikan University, Shiga 525-8577, Japan;
FAU - Banchereau, Jacques
AU  - Banchereau J
AD  - The Jackson Laboratory for Genomic Medicine, Farmington, CT 06030; and.
FAU - Merad, Miriam
AU  - Merad M
AD  - Immunology Institute, Mount Sinai School of Medicine, New York, NY 10029; 
      Department of Oncological Sciences, Mount Sinai School of Medicine, New York, NY 
      10029.
FAU - Palucka, A Karolina
AU  - Palucka AK
AD  - Baylor Institute for Immunology Research, Dallas, TX 75204; 
      Karolina.Palucka@jax.org.
LA  - eng
GR  - 5T32CA078207-12/CA/NCI NIH HHS/United States
GR  - U19AI057234/AI/NIAID NIH HHS/United States
GR  - U19AI089987/AI/NIAID NIH HHS/United States
GR  - R01 CA154947/CA/NCI NIH HHS/United States
GR  - P30 CA034196/CA/NCI NIH HHS/United States
GR  - U01AI095611/AI/NIAID NIH HHS/United States
GR  - T32 CA078207/CA/NCI NIH HHS/United States
GR  - U19 AI057234/AI/NIAID NIH HHS/United States
GR  - U01 AI095611/AI/NIAID NIH HHS/United States
GR  - R01 CA173861/CA/NCI NIH HHS/United States
GR  - U19 AI089987/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20140922
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Antigens, CD1)
RN  - 0 (Antigens, Surface)
RN  - 0 (CD1C protein, human)
RN  - 0 (CD40 Antigens)
RN  - 0 (Cytokines)
RN  - 0 (Glycoproteins)
RN  - 0 (OX40 Ligand)
RN  - 0 (THBD protein, human)
RN  - 0 (Thrombomodulin)
SB  - IM
EIN - J Immunol. 2014 Dec 15;193(12):6210
MH  - Animals
MH  - Antigens, CD1/metabolism
MH  - Antigens, Surface/*metabolism
MH  - CD4-Positive T-Lymphocytes/cytology/*immunology/metabolism
MH  - CD40 Antigens/metabolism
MH  - Cell Differentiation
MH  - Cells, Cultured
MH  - Cytokines/*biosynthesis
MH  - Dendritic Cells/*immunology/metabolism
MH  - Glycoproteins/metabolism
MH  - Humans
MH  - Immunophenotyping
MH  - Lung/immunology/metabolism/virology
MH  - Lymphocyte Activation/immunology
MH  - Mice
MH  - Mice, Knockout
MH  - OX40 Ligand/metabolism
MH  - Orthomyxoviridae/immunology
MH  - Phenotype
MH  - Signal Transduction
MH  - Th2 Cells/immunology/metabolism
MH  - Thrombomodulin
PMC - PMC4201960
MID - NIHMS625022
EDAT- 2014/09/24 06:00
MHDA- 2015/03/04 06:00
PMCR- 2015/11/01
CRDT- 2014/09/24 06:00
PHST- 2014/09/24 06:00 [entrez]
PHST- 2014/09/24 06:00 [pubmed]
PHST- 2015/03/04 06:00 [medline]
PHST- 2015/11/01 00:00 [pmc-release]
AID - jimmunol.1401159 [pii]
AID - 10.4049/jimmunol.1401159 [doi]
PST - ppublish
SO  - J Immunol. 2014 Nov 1;193(9):4335-43. doi: 10.4049/jimmunol.1401159. Epub 2014 
      Sep 22.