PMID- 25246547
OWN - NLM
STAT- MEDLINE
DCOM- 20150430
LR  - 20211021
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Print)
IS  - 0027-8424 (Linking)
VI  - 111
IP  - 41
DP  - 2014 Oct 14
TI  - Neuronal mechanism for acute mechanosensitivity in tactile-foraging waterfowl.
PG  - 14941-6
LID - 10.1073/pnas.1413656111 [doi]
AB  - Relying almost exclusively on their acute sense of touch, tactile-foraging birds 
      can feed in murky water, but the cellular mechanism is unknown. Mechanical 
      stimuli activate specialized cutaneous end organs in the bill, innervated by 
      trigeminal afferents. We report that trigeminal ganglia (TG) of domestic and wild 
      tactile-foraging ducks exhibit numerical expansion of large-diameter 
      mechanoreceptive neurons expressing the mechano-gated ion channel Piezo2. These 
      features are not found in visually foraging birds. Moreover, in the duck, the 
      expansion of mechanoreceptors occurs at the expense of thermosensors. Direct 
      mechanical stimulation of duck TG neurons evokes high-amplitude depolarizing 
      current with a low threshold of activation, high signal amplification gain, and 
      slow kinetics of inactivation. Together, these factors contribute to efficient 
      conversion of light mechanical stimuli into neuronal excitation. Our results 
      reveal an evolutionary strategy to hone tactile perception in vertebrates at the 
      level of primary afferents.
FAU - Schneider, Eve R
AU  - Schneider ER
AD  - Department of Cellular and Molecular Physiology.
FAU - Mastrotto, Marco
AU  - Mastrotto M
AD  - Department of Cellular and Molecular Physiology, Yale Program in Cellular 
      Neuroscience, Neurodegeneration and Repair.
FAU - Laursen, Willem J
AU  - Laursen WJ
AD  - Department of Cellular and Molecular Physiology, Yale Program in Cellular 
      Neuroscience, Neurodegeneration and Repair.
FAU - Schulz, Vincent P
AU  - Schulz VP
AD  - Department of Pediatrics, Yale University School of Medicine, New Haven, CT 
      06520.
FAU - Goodman, Jena B
AU  - Goodman JB
AD  - Department of Cellular and Molecular Physiology, Yale Program in Cellular 
      Neuroscience, Neurodegeneration and Repair.
FAU - Funk, Owen H
AU  - Funk OH
AD  - Department of Cellular and Molecular Physiology.
FAU - Gallagher, Patrick G
AU  - Gallagher PG
AD  - Department of Pediatrics, Yale University School of Medicine, New Haven, CT 
      06520.
FAU - Gracheva, Elena O
AU  - Gracheva EO
AD  - Department of Cellular and Molecular Physiology, Yale Program in Cellular 
      Neuroscience, Neurodegeneration and Repair, sviatoslav.bagriantsev@yale.edu 
      elena.gracheva@yale.edu.
FAU - Bagriantsev, Sviatoslav N
AU  - Bagriantsev SN
AD  - Department of Cellular and Molecular Physiology, sviatoslav.bagriantsev@yale.edu 
      elena.gracheva@yale.edu.
LA  - eng
GR  - T32 HD007094/HD/NICHD NIH HHS/United States
GR  - UL1 TR000142/TR/NCATS NIH HHS/United States
GR  - T32HG319810/HG/NHGRI NIH HHS/United States
GR  - T32HD007094/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20140922
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Ion Channels)
RN  - 0 (TRPM Cation Channels)
RN  - 0 (TRPV Cation Channels)
SB  - IM
MH  - Animals
MH  - Down-Regulation
MH  - Ducks/*physiology
MH  - *Feeding Behavior
MH  - Ion Channel Gating
MH  - Ion Channels/metabolism
MH  - *Mechanotransduction, Cellular
MH  - Neurons/*physiology
MH  - Sensory Thresholds
MH  - TRPM Cation Channels/metabolism
MH  - TRPV Cation Channels/metabolism
MH  - Thermoreceptors/metabolism
MH  - Touch/*physiology
MH  - Trigeminal Ganglion/physiology
MH  - Up-Regulation
PMC - PMC4205607
OTO - NOTNLM
OT  - Piezo2
OT  - TRPM8
OT  - TRPV1
OT  - mechanotransduction
COIS- The authors declare no conflict of interest.
EDAT- 2014/09/24 06:00
MHDA- 2015/05/01 06:00
PMCR- 2015/04/14
CRDT- 2014/09/24 06:00
PHST- 2014/09/24 06:00 [entrez]
PHST- 2014/09/24 06:00 [pubmed]
PHST- 2015/05/01 06:00 [medline]
PHST- 2015/04/14 00:00 [pmc-release]
AID - 1413656111 [pii]
AID - 201413656 [pii]
AID - 10.1073/pnas.1413656111 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14941-6. doi: 
      10.1073/pnas.1413656111. Epub 2014 Sep 22.