PMID- 25247018
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140923
LR  - 20211021
IS  - 1918-3003 (Print)
IS  - 1918-3011 (Electronic)
IS  - 1918-3003 (Linking)
VI  - 6
IP  - 6
DP  - 2014 Dec
TI  - Correlation between serum uric Acid and renal function in patients with stable 
      coronary artery disease and type 2 diabetes.
PG  - 443-50
LID - 10.14740/jocmr1909w [doi]
AB  - BACKGROUND: The aim of this study was to investigate the relationship between 
      serum uric acid and renal function, expressed as estimated glomerular filtration 
      rate (eGFR), in patients with stable coronary artery disease (CAD) and type 2 
      diabetes mellitus (T2DM) in China. METHODS: Serum levels of uric acid and 
      creatinine were determined in 526 enrolled patients diagnosed with stable CAD and 
      T2DM. To assess renal function, eGFR was calculated using a modified MDRD formula 
      suitable for the Chinese population. Patients' anthropometric measurements were 
      collected using standardized protocols, and 6-month follow-up results were 
      collected and analyzed. Pearson's correlation coefficient r was calculated and 
      multivariate analysis was performed to evaluate the relationship between uric 
      acid and renal function. Patients with eGFR < 60 mL/min/1.73 m(2) were classified 
      as having reduced renal function or chronic kidney disease (CKD) in this study. 
      RESULTS: Uric acid levels were negatively associated with eGFR (P = 0.002), 
      especially in patients with CKD (eGFR < 60 mL/min/1.73 m(2)) (P < 0.001). In 
      patients with reduced renal function, the risk in the highest quartile of uric 
      acid levels was higher than in the lowest quartile (odds ratio 9.18, 95% 
      confidence interval: 4.01 - 21.01, P < 0.001). These associations remained after 
      multiple adjustments for potential confounders and were recapitulated after 
      6-month follow-up. CONCLUSIONS: Serum uric acid level is negatively associated 
      with renal function, as assessed by eGFR, and serves as an independent predictor 
      for CKD in patients with stable CAD and T2DM.
FAU - Chen, Zhong
AU  - Chen Z
AD  - Department of Cardiology, The Affiliated Sixth People's Hospital of Shanghai Jiao 
      Tong University, No. 600 Yishan Road, Shanghai 200233, China.
FAU - Ding, Zhen
AU  - Ding Z
AD  - Department of Cardiology, Zhenjiang First People's Hospital, Zhenjiang 212002, 
      China.
FAU - Fu, Cong
AU  - Fu C
AD  - Department of Cardiology, The Affiliated Zhongda Hospital of Southeast 
      University, No. 87 Dingjiaqiao, Nanjing 210009, China.
FAU - Yu, Chaojun
AU  - Yu C
AD  - Department of Cardiology, The Affiliated Zhongda Hospital of Southeast 
      University, No. 87 Dingjiaqiao, Nanjing 210009, China.
FAU - Ma, Genshan
AU  - Ma G
AD  - Department of Cardiology, The Affiliated Zhongda Hospital of Southeast 
      University, No. 87 Dingjiaqiao, Nanjing 210009, China.
LA  - eng
PT  - Journal Article
DEP - 20140909
PL  - Canada
TA  - J Clin Med Res
JT  - Journal of clinical medicine research
JID - 101538301
PMC - PMC4169086
OTO - NOTNLM
OT  - Estimated glomerular filtration rate
OT  - Follow-up
OT  - Stable coronary artery disease
OT  - Type 2 diabetes mellitus
OT  - Uric acid
EDAT- 2014/09/24 06:00
MHDA- 2014/09/24 06:01
PMCR- 2014/09/09
CRDT- 2014/09/24 06:00
PHST- 2014/07/08 00:00 [accepted]
PHST- 2014/09/24 06:00 [entrez]
PHST- 2014/09/24 06:00 [pubmed]
PHST- 2014/09/24 06:01 [medline]
PHST- 2014/09/09 00:00 [pmc-release]
AID - 10.14740/jocmr1909w [doi]
PST - ppublish
SO  - J Clin Med Res. 2014 Dec;6(6):443-50. doi: 10.14740/jocmr1909w. Epub 2014 Sep 9.