PMID- 25247581
OWN - NLM
STAT- MEDLINE
DCOM- 20150622
LR  - 20211021
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 15
IP  - 9
DP  - 2014 Sep 22
TI  - Melatonin regulates aging and neurodegeneration through energy metabolism, 
      epigenetics, autophagy and circadian rhythm pathways.
PG  - 16848-84
LID - 10.3390/ijms150916848 [doi]
AB  - Brain aging is linked to certain types of neurodegenerative diseases and 
      identifying new therapeutic targets has become critical. Melatonin, a pineal 
      hormone, associates with molecules and signaling pathways that sense and 
      influence energy metabolism, autophagy, and circadian rhythms, including 
      insulin-like growth factor 1 (IGF-1), Forkhead box O (FoxOs), sirtuins and 
      mammalian target of rapamycin (mTOR) signaling pathways. This review summarizes 
      the current understanding of how melatonin, together with molecular, cellular and 
      systemic energy metabolisms, regulates epigenetic processes in the neurons. This 
      information will lead to a greater understanding of molecular epigenetic aging of 
      the brain and anti-aging mechanisms to increase lifespan under healthy 
      conditions.
FAU - Jenwitheesuk, Anorut
AU  - Jenwitheesuk A
AD  - Research Center for Neuroscience, Institute of Molecular Biosciences, Mahidol 
      University, Salaya, Nakornpathom 73170, Thailand. anorutj@gmail.com.
FAU - Nopparat, Chutikorn
AU  - Nopparat C
AD  - Research Center for Neuroscience, Institute of Molecular Biosciences, Mahidol 
      University, Salaya, Nakornpathom 73170, Thailand. chukorn.nop@mahidol.ac.th.
FAU - Mukda, Sujira
AU  - Mukda S
AD  - Research Center for Neuroscience, Institute of Molecular Biosciences, Mahidol 
      University, Salaya, Nakornpathom 73170, Thailand. sujira.muk@mahidol.ac.th.
FAU - Wongchitrat, Prapimpun
AU  - Wongchitrat P
AD  - Center for Innovation Development and Technology Transfer, Faculty of Medical 
      Technology, Mahidol University, Salaya, Nakornpathom 73170, Thailand. 
      prapimpun.won@mahidol.ac.th.
FAU - Govitrapong, Piyarat
AU  - Govitrapong P
AD  - Research Center for Neuroscience, Institute of Molecular Biosciences, Mahidol 
      University, Salaya, Nakornpathom 73170, Thailand. piyarat.gov@mahidol.ac.th.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140922
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (Insulin)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - EC 3.5.1.- (Sirtuins)
RN  - JL5DK93RCL (Melatonin)
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - Autophagy/*physiology
MH  - Brain/growth & development/metabolism
MH  - Caloric Restriction
MH  - Circadian Rhythm/genetics/*physiology
MH  - Diabetes Mellitus/physiopathology
MH  - Energy Metabolism/*physiology
MH  - Epigenesis, Genetic/*physiology
MH  - Forkhead Transcription Factors/physiology
MH  - Gene Expression Regulation/physiology
MH  - Humans
MH  - Inflammation/physiopathology
MH  - Insulin/physiology
MH  - Insulin Resistance/physiology
MH  - Insulin-Like Growth Factor I/physiology
MH  - Longevity/physiology
MH  - Melatonin/*physiology
MH  - Memory/physiology
MH  - Nerve Degeneration/*physiopathology
MH  - Obesity/physiopathology
MH  - Signal Transduction/physiology
MH  - Sirtuins/physiology
PMC - PMC4200827
EDAT- 2014/09/24 06:00
MHDA- 2015/06/24 06:00
PMCR- 2014/09/01
CRDT- 2014/09/24 06:00
PHST- 2014/07/25 00:00 [received]
PHST- 2014/09/03 00:00 [revised]
PHST- 2014/09/12 00:00 [accepted]
PHST- 2014/09/24 06:00 [entrez]
PHST- 2014/09/24 06:00 [pubmed]
PHST- 2015/06/24 06:00 [medline]
PHST- 2014/09/01 00:00 [pmc-release]
AID - ijms150916848 [pii]
AID - ijms-15-16848 [pii]
AID - 10.3390/ijms150916848 [doi]
PST - epublish
SO  - Int J Mol Sci. 2014 Sep 22;15(9):16848-84. doi: 10.3390/ijms150916848.