PMID- 25248611
OWN - NLM
STAT- MEDLINE
DCOM- 20150122
LR  - 20211021
IS  - 1544-0591 (Electronic)
IS  - 0022-0345 (Print)
IS  - 0022-0345 (Linking)
VI  - 93
IP  - 12
DP  - 2014 Dec
TI  - Synthesis of carboxylic block copolymers via reversible addition fragmentation 
      transfer polymerization for tooth erosion prevention.
PG  - 1264-9
LID - 10.1177/0022034514551609 [doi]
AB  - Dental professionals are seeing a growing population of patients with visible 
      signs of dental erosion. The approach currently being used to address the problem 
      typically leverages the enamel protection benefits of fluoride. In this report, 
      an alternative new block copolymer with a hydrophilic polyacrylic acid (PAA) 
      block and a hydrophobic poly(methyl methacrylate) (PMMA) block was developed to 
      similarly reduce the mineral loss from enamel under acidic conditions. This 
      series of PMMA-b-PAA block copolymers was synthesized by reversible addition 
      fragmentation transfer (RAFT) polymerization. Their structures were characterized 
      by gel permeation chromatography (GPC) and (1)H nuclear magnetic resonance (NMR) 
      spectra. The molar fractions of acrylic acid (AA) in the final block copolymer 
      were finely controlled from 0.25 to 0.94, and the molecular weight (Mn) of 
      PMMA-b-PAA was controlled from 10 kDa to 90 kDa. The binding capability of the 
      block copolymer with hydroxyapatite (HAP) was investigated by ultraviolet-visible 
      spectroscopy (UV-Vis) and Fourier transform infrared (FTIR) spectroscopy. FTIR 
      spectra confirmed that the PMMA-b-PAA block copolymer could bind to HAP via 
      bridging bidentate bonds. Both UV-Vis and FTIR spectra additionally indicated 
      that a high polymer concentration and low solution pH favored the polymer binding 
      to HAP. The erosion-preventing efficacy of the PMMA-b-PAA block copolymer in 
      inhibiting HAP mineral loss was quantitatively evaluated by atomic absorption 
      spectroscopy (AAS). Based on the results, polymer treatment reduced the amount of 
      calcium released by 27% to 30% in comparison with the unprotected samples. 
      Scanning electron microscope (SEM) observations indicated that PMMA-b-PAA polymer 
      treatment protected enamel from acid erosion. This new amphiphilic block 
      copolymer has significant potential to be integrated into dentifrices or 
      mouthrinses as an alternative non-fluoride ingredient to reduce tooth erosion.
CI  - (c) International & American Associations for Dental Research.
FAU - Lei, Y
AU  - Lei Y
AD  - College of Dentistry, Howard University, Washington, DC 20059, USA CREST Center 
      for Nanomaterials, College of Engineering, Howard University, Washington, DC 
      20059, USA.
FAU - Wang, T
AU  - Wang T
AD  - College of Dentistry, Howard University, Washington, DC 20059, USA CREST Center 
      for Nanomaterials, College of Engineering, Howard University, Washington, DC 
      20059, USA twang@howard.edu.
FAU - Mitchell, J W
AU  - Mitchell JW
AD  - CREST Center for Nanomaterials, College of Engineering, Howard University, 
      Washington, DC 20059, USA.
FAU - Qiu, J
AU  - Qiu J
AD  - Colgate-Palmolive Company, Piscataway, NJ 08855, USA.
FAU - Kilpatrick-Liverman, L
AU  - Kilpatrick-Liverman L
AD  - Colgate-Palmolive Company, Piscataway, NJ 08855, USA.
LA  - eng
GR  - R01 DE021786/DE/NIDCR NIH HHS/United States
GR  - R01DE021786/DE/NIDCR NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20140923
PL  - United States
TA  - J Dent Res
JT  - Journal of dental research
JID - 0354343
RN  - 0 (Acrylic Resins)
RN  - 0 (Dental Materials)
RN  - 4Q93RCW27E (carbopol 940)
RN  - 9011-14-7 (Polymethyl Methacrylate)
RN  - 91D9GV0Z28 (Durapatite)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Acrylic Resins/*chemical synthesis/chemistry
MH  - Animals
MH  - Calcium/chemistry
MH  - Cattle
MH  - Chromatography, Gel
MH  - Dental Enamel/chemistry/ultrastructure
MH  - Dental Materials/*chemical synthesis/chemistry
MH  - Durapatite/chemistry
MH  - Hydrogen-Ion Concentration
MH  - Hydrophobic and Hydrophilic Interactions
MH  - Magnetic Resonance Spectroscopy
MH  - Materials Testing
MH  - Microscopy, Electron, Scanning
MH  - Molecular Weight
MH  - Polymerization
MH  - Polymethyl Methacrylate/*chemical synthesis/chemistry
MH  - Spectrophotometry
MH  - Spectrophotometry, Atomic
MH  - Spectroscopy, Fourier Transform Infrared
MH  - Tooth Erosion/prevention & control
PMC - PMC4237637
OTO - NOTNLM
OT  - RAFT polymerization
OT  - binding
OT  - dental erosion
OT  - enamel
OT  - hydroxyapatite
OT  - surface
COIS- The authors declare no potential conflicts of interest with respect to the 
      authorship and/or publication of this article.
EDAT- 2014/09/25 06:00
MHDA- 2015/01/23 06:00
PMCR- 2015/12/01
CRDT- 2014/09/25 06:00
PHST- 2014/09/25 06:00 [entrez]
PHST- 2014/09/25 06:00 [pubmed]
PHST- 2015/01/23 06:00 [medline]
PHST- 2015/12/01 00:00 [pmc-release]
AID - 0022034514551609 [pii]
AID - 10.1177_0022034514551609 [pii]
AID - 10.1177/0022034514551609 [doi]
PST - ppublish
SO  - J Dent Res. 2014 Dec;93(12):1264-9. doi: 10.1177/0022034514551609. Epub 2014 Sep 
      23.