PMID- 25249767
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140924
LR  - 20211021
IS  - 1179-5735 (Print)
IS  - 1179-5735 (Electronic)
IS  - 1179-5735 (Linking)
VI  - 6
DP  - 2014
TI  - Increased Epidermal Growth Factor Receptor (EGFR) Associated with Hepatocyte 
      Growth Factor (HGF) and Symptom Severity in Children with Autism Spectrum 
      Disorders (ASDs).
PG  - 79-83
LID - 10.4137/JCNSD.S13767 [doi]
AB  - BACKGROUND: One in 88 children in the US is thought to have one of the autism 
      spectrum disorders (ASDs). ASDs are characterized by social impairments and 
      communication problems. Growth factors and their receptors may play a role in the 
      etiology of ASDs. Research has shown that epidermal growth factor receptor (EGFR) 
      activation is associated with nerve cell development and repair. This study was 
      designed to measure plasma levels of EGFR in autistic children and correlate 
      these levels with its ligand, epidermal growth factor, other related putative 
      biomarkers such as hepatocyte growth factor (HGF), the ligand for MET (MNNG HOS 
      transforming gene) receptor, as well as the symptom severity of 19 different 
      behavioral symptoms. SUBJECTS AND METHODS: Plasma EGFR concentration was measured 
      in 33 autistic children and 34 age- and gender-similar neurotypical controls, 
      using an enzyme-linked immunosorbent assay. Plasma EGFR levels were compared to 
      putative biomarkers known to be associated with EGFR and MET and severity levels 
      of 19 autism-related symptoms. RESULTS: We found plasma EGFR levels significantly 
      higher in autistic children, when compared to neurotypical controls. EGFR levels 
      correlated with HGF and high-mobility group protein B1 (HMGB1) levels, but not 
      other tested putative biomarkers, and EGFR levels correlated significantly with 
      severity of expressive language, conversational language, focus/attention, 
      hyperactivity, eye contact, and sound sensitivity deficiencies. CONCLUSIONS: 
      These results suggest a relationship between increased plasma EGFR levels and 
      designated symptom severity in autistic children. A strong correlation between 
      plasma EGFR and HGF and HMGB1 suggests that increased EGFR levels may be 
      associated with the HGF/Met signaling pathway, as well as inflammation.
FAU - Russo, Anthony J
AU  - Russo AJ
AD  - Hartwick College, Oneonta, NY, Health Research Institute and Pfeiffer Medical 
      Center, Warrenville, IL.
LA  - eng
GR  - U24 MH081810/MH/NIMH NIH HHS/United States
PT  - Journal Article
DEP - 20140909
PL  - United States
TA  - J Cent Nerv Syst Dis
JT  - Journal of central nervous system disease
JID - 101595026
PMC - PMC4167315
OTO - NOTNLM
OT  - EGF
OT  - EGFR
OT  - HGF
OT  - HMGB1
OT  - autism
OT  - symptom severity
EDAT- 2014/09/25 06:00
MHDA- 2014/09/25 06:01
PMCR- 2014/09/09
CRDT- 2014/09/25 06:00
PHST- 2014/01/27 00:00 [received]
PHST- 2014/06/14 00:00 [revised]
PHST- 2014/06/19 00:00 [accepted]
PHST- 2014/09/25 06:00 [entrez]
PHST- 2014/09/25 06:00 [pubmed]
PHST- 2014/09/25 06:01 [medline]
PHST- 2014/09/09 00:00 [pmc-release]
AID - jcnsd-6-2014-079 [pii]
AID - 10.4137/JCNSD.S13767 [doi]
PST - epublish
SO  - J Cent Nerv Syst Dis. 2014 Sep 9;6:79-83. doi: 10.4137/JCNSD.S13767. eCollection 
      2014.