PMID- 25250312
OWN - NLM
STAT- MEDLINE
DCOM- 20150615
LR  - 20211021
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2014
DP  - 2014
TI  - Relationship between CCR and NT-proBNP in Chinese HF patients, and their 
      correlations with severity of HF.
PG  - 106252
LID - 10.1155/2014/106252 [doi]
LID - 106252
AB  - AIM: To evaluate the relationship between creatinine clearance rate (CCR) and the 
      level of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in heart failure 
      (HF) patients and their correlations with HF severity. METHODS AND RESULTS: Two 
      hundred and one Chinese patients were grouped according to the New York Heart 
      Association (NYHA) classification as NYHA 1-2 and 3-4 groups and 135 cases out of 
      heart failure patients as control group. The following variables were compared 
      among these three groups: age, sex, body mass index (BMI), smoking status, 
      hypertension, diabetes, NT-proBNP, creatinine (Cr), uric acid (UA), left 
      ventricular end-diastolic diameter (LVEDD), and CCR. The biomarkers of NT-proBNP, 
      Cr, UA, LVEDD, and CCR varied significantly in the three groups, and these 
      variables were positively correlated with the NHYA classification. The levels of 
      NT-proBNP and CCR were closely related to the occurrence of HF and were 
      independent risk factors for HF. At the same time, there was a significant 
      negative correlation between the levels of NT-proBNP and CCR. The area under the 
      receiver operating characteristic curve suggested that the NT-proBNP and CCR have 
      high accuracy for diagnosis of HF and have clinical diagnostic value. CONCLUSION: 
      NT-proBNP and CCR may be important biomarkers in evaluating the severity of HF.
FAU - Lu, Zhigang
AU  - Lu Z
AD  - Department of Cardiology, The 6th People's Hospital Affiliated to Shanghai 
      Jiaotong University Medical College, No. 600 Yishan Road, Shanghai, China.
FAU - Wang, Bo
AU  - Wang B
AD  - Department of Clinical Laboratory, Dalian Municipal Central Hospital, Dalian, 
      China.
FAU - Wang, Yunliang
AU  - Wang Y
AD  - Department of Neurology, The 148th Hospital, Zibo, Shandong, China.
FAU - Qian, Xueqing
AU  - Qian X
AD  - Medlogic Healthcare Technology Company Ltd., Shanghai, China.
FAU - Zheng, Wei
AU  - Zheng W
AD  - Laboratory of Medicine, General Hospital of Shenyang Military Area Command, 
      Shenyang, China.
FAU - Wei, Meng
AU  - Wei M
AD  - Department of Cardiology, The 6th People's Hospital Affiliated to Shanghai 
      Jiaotong University Medical College, No. 600 Yishan Road, Shanghai, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140828
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Biomarkers)
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Age Distribution
MH  - Aged
MH  - Biomarkers/blood
MH  - China/epidemiology
MH  - Creatinine/*blood
MH  - Female
MH  - *Glomerular Filtration Rate
MH  - Heart Failure/blood/*diagnosis/*epidemiology
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Natriuretic Peptide, Brain/*blood
MH  - Peptide Fragments/*blood
MH  - Prognosis
MH  - Reproducibility of Results
MH  - Risk Factors
MH  - Sensitivity and Specificity
MH  - *Severity of Illness Index
MH  - Sex Distribution
MH  - Smoking/epidemiology
MH  - Statistics as Topic
PMC - PMC4164506
EDAT- 2014/09/25 06:00
MHDA- 2015/06/16 06:00
PMCR- 2014/08/28
CRDT- 2014/09/25 06:00
PHST- 2014/07/11 00:00 [received]
PHST- 2014/08/15 00:00 [accepted]
PHST- 2014/09/25 06:00 [entrez]
PHST- 2014/09/25 06:00 [pubmed]
PHST- 2015/06/16 06:00 [medline]
PHST- 2014/08/28 00:00 [pmc-release]
AID - 10.1155/2014/106252 [doi]
PST - ppublish
SO  - Biomed Res Int. 2014;2014:106252. doi: 10.1155/2014/106252. Epub 2014 Aug 28.