PMID- 25251832
OWN - NLM
STAT- MEDLINE
DCOM- 20150213
LR  - 20220330
IS  - 1096-9896 (Electronic)
IS  - 0022-3417 (Linking)
VI  - 235
IP  - 2
DP  - 2015 Jan
TI  - HIV and the spectrum of human disease.
PG  - 229-41
LID - 10.1002/path.4449 [doi]
AB  - Infection with the human immunodeficiency virus (HIV) causes systemic T cell 
      destruction and reduced cell-mediated immunity that leads to a wide range of 
      opportunistic infections and cancers. Second, it directly damages many tissues - 
      gut, brain, lung - through mononuclear cell infection and activation. Third, 
      through immune activation and effects on endothelia, it can cause more subtle 
      systemic organ damage, such as chronic cardiovascular, hepatic, pulmonary and 
      central nervous system disease. Antiretroviral treatment has enabled HIV-infected 
      persons to live with chronic infection, although with some side-effects and 
      mortality, including reactions due to the immune reconstitution inflammatory 
      syndrome (IRIS). As cohorts of infected people get older, age-related diseases 
      will combine with chronic HIV infection to produce disabilities whose scale is 
      not yet understood. HIV is detectable in tissues by immunohistochemistry when 
      infection loads are high, such as at first presentation. Pathologists should 
      proactively consider HIV disease in routine diagnostic work, so as to identify 
      more HIV-infected patients and enable their optimal management.
CI  - Copyright (c) 2014 Pathological Society of Great Britain and Ireland. Published by 
      John Wiley & Sons, Ltd.
FAU - Lucas, Sebastian
AU  - Lucas S
AD  - Department of Histopathology, St Thomas' Hospital, London, UK.
FAU - Nelson, Ann Marie
AU  - Nelson AM
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Pathol
JT  - The Journal of pathology
JID - 0204634
RN  - 0 (Anti-HIV Agents)
SB  - IM
MH  - Animals
MH  - Anti-HIV Agents/therapeutic use
MH  - Biopsy
MH  - HIV/drug effects/genetics/immunology/*pathogenicity
MH  - HIV Infections/drug therapy/epidemiology/immunology/pathology/*virology
MH  - HIV Long-Term Survivors
MH  - Host-Pathogen Interactions
MH  - Humans
MH  - Pathology, Molecular/methods
MH  - Predictive Value of Tests
MH  - T-Lymphocytes/drug effects/immunology/*virology
MH  - Time Factors
MH  - Treatment Outcome
MH  - Virology/methods
MH  - Virulence
OTO - NOTNLM
OT  - AIDS
OT  - HIV
OT  - HIVp24
OT  - IRIS
OT  - immune activation
OT  - pathology
OT  - review
EDAT- 2014/09/25 06:00
MHDA- 2015/02/14 06:00
CRDT- 2014/09/25 06:00
PHST- 2014/08/01 00:00 [received]
PHST- 2014/09/12 00:00 [revised]
PHST- 2014/09/15 00:00 [accepted]
PHST- 2014/09/25 06:00 [entrez]
PHST- 2014/09/25 06:00 [pubmed]
PHST- 2015/02/14 06:00 [medline]
AID - 10.1002/path.4449 [doi]
PST - ppublish
SO  - J Pathol. 2015 Jan;235(2):229-41. doi: 10.1002/path.4449.