PMID- 25252119
OWN - NLM
STAT- MEDLINE
DCOM- 20150921
LR  - 20150224
IS  - 1440-1746 (Electronic)
IS  - 0815-9319 (Linking)
VI  - 30
IP  - 3
DP  - 2015 Mar
TI  - Effect of low-dose proton pump inhibitor on preventing upper gastrointestinal 
      bleeding in chronic kidney disease patients receiving aspirin.
PG  - 478-84
LID - 10.1111/jgh.12780 [doi]
AB  - BACKGROUND AND AIM: Upper gastrointestinal bleeding (UGIB) leads to significant 
      morbidity and mortality in chronic kidney disease (CKD) patients. This study 
      determined the efficacy of using a low-dose proton pump inhibitor (PPI) to reduce 
      the risk of non-variceal UGIB in CKD patients receiving aspirin. METHODS: We 
      retrospectively reviewed the medical records of 500 CKD patients who received 
      aspirin between January 2008 and March 2013. Cumulative incidence analysis using 
      the Kaplan-Meier method was performed to analyze the rate of non-variceal UGIB 
      and association with the administration of low-dose PPI. RESULTS: Of the 500 
      patients, 191 received low-dose PPI. Over the follow-up period, which lasted 1067 
      person-years, three patients in the low-dose PPI group (8.9 per 1000 
      person-years) and 19 patients in the non-PPI group (25.9 per 1000 person-years) 
      developed non-variceal UGIB, respectively (P = 0.113). Low-dose PPI use did not 
      decrease the risk of UGIB in CKD patients, including patients who did not receive 
      dialysis (P = 0.127). However, according to the subgroup analysis of 230 patients 
      who received dialysis, the low-dose PPI group (14.4 per 1000 person-years) 
      demonstrated significantly reduced incidence and risk of non-variceal UGIB in 
      comparison with the non-PPI group (53.8 per 1000 person-years) (P = 0.032). 
      CONCLUSION: Prophylactic low-dose PPI can reduce the risk of non-variceal UGIB in 
      dialysis patients receiving aspirin.
CI  - (c) 2014 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing 
      Asia Pty Ltd.
FAU - Lim, Hyun
AU  - Lim H
AD  - Department of Internal Medicine, Hallym University College of Medicine, Anyang, 
      South Korea.
FAU - Kim, Jong Hyeok
AU  - Kim JH
FAU - Baik, Gwang Ho
AU  - Baik GH
FAU - Park, Ji Won
AU  - Park JW
FAU - Kang, Ho Suk
AU  - Kang HS
FAU - Moon, Sung Hoon
AU  - Moon SH
FAU - Park, Choong Kee
AU  - Park CK
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Gastroenterol Hepatol
JT  - Journal of gastroenterology and hepatology
JID - 8607909
RN  - 0 (Proton Pump Inhibitors)
RN  - R16CO5Y76E (Aspirin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aspirin/*adverse effects/therapeutic use
MH  - Dialysis
MH  - Female
MH  - Follow-Up Studies
MH  - Gastrointestinal Hemorrhage/*chemically 
      induced/epidemiology/mortality/*prevention & control
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Proton Pump Inhibitors/*administration & dosage
MH  - Renal Insufficiency, Chronic/*therapy
MH  - Retrospective Studies
MH  - Risk
MH  - Survival Rate
MH  - Treatment Outcome
OTO - NOTNLM
OT  - prophylaxis
OT  - proton pump inhibitors
OT  - upper gastrointestinal bleeding
EDAT- 2014/09/25 06:00
MHDA- 2015/09/22 06:00
CRDT- 2014/09/25 06:00
PHST- 2014/09/15 00:00 [accepted]
PHST- 2014/09/25 06:00 [entrez]
PHST- 2014/09/25 06:00 [pubmed]
PHST- 2015/09/22 06:00 [medline]
AID - 10.1111/jgh.12780 [doi]
PST - ppublish
SO  - J Gastroenterol Hepatol. 2015 Mar;30(3):478-84. doi: 10.1111/jgh.12780.