PMID- 25252846
OWN - NLM
STAT- MEDLINE
DCOM- 20150310
LR  - 20220324
IS  - 1423-0380 (Electronic)
IS  - 1010-4283 (Linking)
VI  - 35
IP  - 12
DP  - 2014 Dec
TI  - A novel NF-kappaB/MMP-3 signal pathway involves in the aggressivity of glioma 
      promoted by Bmi-1.
PG  - 12721-7
LID - 10.1007/s13277-014-2597-2 [doi]
AB  - Matrix metalloproteinase 3 (MMP-3) is implicated in the pathogenesis and 
      progression of glioma. However, whether MMP-3 participates in the regulation of 
      metastasis and its mechanisms in glioma is mostly unknown. In the present study, 
      glioma cells were stably transfected with Bmi-1 small interfering RNA (siRNA) to 
      knockdown off Bmi-1 or were transiently transfected with Bmi-1 complementary DNA 
      (cDNA) to upregulate the Bmi-1 level and to evaluate their effects on invasion 
      and expression analysis for molecules involved in invasion. Knockdown of Bmi-1 
      dramatically reduced a nuclear factor kappa B (NF-kappaB) and MMP-3 expression and 
      activity in T98G cells. When the T98G cells were upregulated in the Bmi-1 levels, 
      the T98G cells were treated with 10 muM BAY 11-7028 to inhibit the NF-kappaB activity. 
      The invasion induced by upregulation of Bmi-1 was severely abolished by BAY 
      11-7028 in Bmi-1 overexpression cells. The T98G cell metastatic potential was 
      increased by overexpression of Bmi-1; completely at the same time, the NF-kappaB 
      activity and MMP-3 expression was also increased. Taken together, these findings 
      suggest that Bmi-1 promotes glioma cell migration and invasion via NF-kappaB-mediated 
      upregulation of MMP-3.
FAU - Sun, Piyun
AU  - Sun P
AD  - Department of Neurology, The Fourth Affiliated Hospital, Harbin Medical 
      University, No. 37 Jiyuan street, Harbin, Heilongjiang, 150001, China.
FAU - Mu, Yulong
AU  - Mu Y
FAU - Zhang, Shuyan
AU  - Zhang S
LA  - eng
PT  - Journal Article
DEP - 20140925
PL  - Netherlands
TA  - Tumour Biol
JT  - Tumour biology : the journal of the International Society for Oncodevelopmental 
      Biology and Medicine
JID - 8409922
RN  - 0 (BMI1 protein, human)
RN  - 0 (NF-kappa B)
RN  - 0 (RNA, Small Interfering)
RN  - EC 2.3.2.27 (Polycomb Repressive Complex 1)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Cell Line, Tumor
MH  - Cell Movement
MH  - Cell Proliferation
MH  - Disease Progression
MH  - Gene Expression
MH  - Gene Expression Regulation, Neoplastic
MH  - Gene Knockdown Techniques
MH  - Glioma/*genetics/*metabolism/pathology
MH  - Humans
MH  - Matrix Metalloproteinase 3/genetics/*metabolism
MH  - NF-kappa B/genetics/*metabolism
MH  - Polycomb Repressive Complex 1/*genetics
MH  - RNA Interference
MH  - RNA, Small Interfering/genetics
MH  - *Signal Transduction
EDAT- 2014/09/26 06:00
MHDA- 2015/03/11 06:00
CRDT- 2014/09/26 06:00
PHST- 2014/07/13 00:00 [received]
PHST- 2014/09/03 00:00 [accepted]
PHST- 2014/09/26 06:00 [entrez]
PHST- 2014/09/26 06:00 [pubmed]
PHST- 2015/03/11 06:00 [medline]
AID - 10.1007/s13277-014-2597-2 [doi]
PST - ppublish
SO  - Tumour Biol. 2014 Dec;35(12):12721-7. doi: 10.1007/s13277-014-2597-2. Epub 2014 
      Sep 25.