PMID- 25253920
OWN - NLM
STAT- MEDLINE
DCOM- 20150624
LR  - 20211021
IS  - 1466-1861 (Electronic)
IS  - 0962-9351 (Print)
IS  - 0962-9351 (Linking)
VI  - 2014
DP  - 2014
TI  - Dendritic cells from aged subjects display enhanced inflammatory responses to 
      Chlamydophila pneumoniae.
PG  - 436438
LID - 10.1155/2014/436438 [doi]
LID - 436438
AB  - Chlamydophila pneumoniae (CPn) is a common respiratory pathogen that causes a 
      chronic and persistent airway infection. The elderly display an increased 
      susceptibility and severity to this infection. However, the underlying mechanisms 
      are not well understood. Dendritic cells (DCs) are the initiators and regulators 
      of immune responses. Therefore, we investigated the role of DCs in the 
      age-associated increased CPn infection in vitro in humans. Though the expression 
      of activation markers was comparable between the two age groups, DCs from aged 
      subjects secreted enhanced levels of proinflammatory mediators such as TNF-alpha and 
      CXCL-10 in response to CPn. In contrast, the secretion of IL-10 and innate 
      interferons, IFN-alpha and IFN-lambda, was severely impaired in DCs from aged donors. The 
      increased activation of DCs from aged subjects to CPn also resulted in enhanced 
      proliferation of CD4 and CD8 T cells in a DC-T coculture. Furthermore, T cells 
      primed with CPn-stimulated DCs from aged subjects secreted increased levels of 
      IFN-gamma and reduced levels of IL-10 compared to DCs obtained from young subjects. 
      In summary, DCs from the elderly displayed enhanced inflammatory response to CPn 
      which may result in airway remodeling and increase the susceptibility of the 
      elderly to respiratory diseases such as asthma.
FAU - Prakash, Sangeetha
AU  - Prakash S
AD  - Division of Basic and Clinical Immunology, Department of Medicine, University of 
      California, Irvine, CA 92697, USA.
FAU - Agrawal, Sudhanshu
AU  - Agrawal S
AD  - Division of Basic and Clinical Immunology, Department of Medicine, University of 
      California, Irvine, CA 92697, USA.
FAU - Ma, Dandan
AU  - Ma D
AUID- ORCID: 0000-0002-3380-5249
AD  - Division of Basic and Clinical Immunology, Department of Medicine, University of 
      California, Irvine, CA 92697, USA.
FAU - Gupta, Sudhir
AU  - Gupta S
AD  - Division of Basic and Clinical Immunology, Department of Medicine, University of 
      California, Irvine, CA 92697, USA.
FAU - Peterson, Ellena M
AU  - Peterson EM
AD  - Department of Pathology and Laboratory Medicine, University of California, 
      Irvine, CA 92697, USA.
FAU - Agrawal, Anshu
AU  - Agrawal A
AUID- ORCID: 0000-0002-3323-9152
AD  - Division of Basic and Clinical Immunology, Department of Medicine, University of 
      California, Irvine, CA 92697, USA.
LA  - eng
PT  - Journal Article
DEP - 20140901
PL  - United States
TA  - Mediators Inflamm
JT  - Mediators of inflammation
JID - 9209001
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - CD4-Positive T-Lymphocytes/metabolism
MH  - CD8-Positive T-Lymphocytes/metabolism
MH  - Cell Proliferation/physiology
MH  - Cells, Cultured
MH  - Chlamydophila pneumoniae/*immunology
MH  - Dendritic Cells/*metabolism
MH  - Female
MH  - Humans
MH  - Inflammation/*immunology/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Young Adult
PMC - PMC4165882
EDAT- 2014/09/26 06:00
MHDA- 2015/06/25 06:00
PMCR- 2014/09/01
CRDT- 2014/09/26 06:00
PHST- 2014/05/12 00:00 [received]
PHST- 2014/08/06 00:00 [revised]
PHST- 2014/08/07 00:00 [accepted]
PHST- 2014/09/26 06:00 [entrez]
PHST- 2014/09/26 06:00 [pubmed]
PHST- 2015/06/25 06:00 [medline]
PHST- 2014/09/01 00:00 [pmc-release]
AID - 10.1155/2014/436438 [doi]
PST - ppublish
SO  - Mediators Inflamm. 2014;2014:436438. doi: 10.1155/2014/436438. Epub 2014 Sep 1.