PMID- 25254036
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140925
LR  - 20220321
IS  - 1664-5464 (Print)
IS  - 1664-5464 (Electronic)
IS  - 1664-5464 (Linking)
VI  - 4
IP  - 2
DP  - 2014 May
TI  - Increased Levels of Chitotriosidase and YKL-40 in Cerebrospinal Fluid from 
      Patients with Alzheimer's Disease.
PG  - 297-304
LID - 10.1159/000362164 [doi]
AB  - BACKGROUND: The cerebrospinal fluid (CSF) biomarkers total tau, abnormally 
      phosphorylated tau and amyloid beta 1-42 are strongly associated with Alzheimer's 
      disease (AD). Apart from the pathologic hallmarks that these biomarkers 
      represent, other processes such as inflammation and microglial activation are 
      present in the brains of patients with AD. New biomarkers related to these 
      processes could be valuable for the diagnosis and follow-up of AD patients and 
      for the evaluation of inflammation-related pathologies. AIM: The aim of this 
      study was to evaluate the association of inflammatory CSF biomarkers with AD. 
      METHODS: Twenty-five AD patients and 25 controls who had a pathological and 
      normal CSF profile of the core AD biomarkers, respectively, were included in this 
      study. CSF levels of chitotriosidase, YKL-40 (also known as chitinase-3-like 
      protein 1) and monocyte chemoattractant protein-1 (MCP-1) were quantified and the 
      levels compared between the groups. RESULTS: AD patients had increased CSF levels 
      of chitotriosidase and YKL-40 (both approximately twice higher than in controls), 
      while the levels of MCP-1 were similar in the AD and control groups. CONCLUSION: 
      The results indicate that chitotriosidase and YKL-40 may be helpful for the 
      evaluation of cerebral inflammatory activity in AD patients.
FAU - Rosen, Christoffer
AU  - Rosen C
AD  - Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, 
      Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy, University 
      of Gothenburg, Molndal, Sweden.
FAU - Andersson, Carl-Henrik
AU  - Andersson CH
AD  - Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, 
      Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy, University 
      of Gothenburg, Molndal, Sweden.
FAU - Andreasson, Ulf
AU  - Andreasson U
AD  - Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, 
      Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy, University 
      of Gothenburg, Molndal, Sweden.
FAU - Molinuevo, Jose L
AU  - Molinuevo JL
AD  - Alzheimer's Disease and Other Cognitive Disorders Unit, Hospital Clinic, IDIBAPS, 
      Barcelona, Spain.
FAU - Bjerke, Maria
AU  - Bjerke M
AD  - Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, 
      Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy, University 
      of Gothenburg, Molndal, Sweden.
FAU - Rami, Lorena
AU  - Rami L
AD  - Alzheimer's Disease and Other Cognitive Disorders Unit, Hospital Clinic, IDIBAPS, 
      Barcelona, Spain.
FAU - Llado, Albert
AU  - Llado A
AD  - Alzheimer's Disease and Other Cognitive Disorders Unit, Hospital Clinic, IDIBAPS, 
      Barcelona, Spain.
FAU - Blennow, Kaj
AU  - Blennow K
AD  - Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, 
      Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy, University 
      of Gothenburg, Molndal, Sweden.
FAU - Zetterberg, Henrik
AU  - Zetterberg H
AD  - Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, 
      Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy, University 
      of Gothenburg, Molndal, Sweden ; UCL Institute of Neurology, London, UK.
LA  - eng
PT  - Journal Article
DEP - 20140731
PL  - Switzerland
TA  - Dement Geriatr Cogn Dis Extra
JT  - Dementia and geriatric cognitive disorders extra
JID - 101564825
PMC - PMC4164083
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Biomarkers
OT  - Cerebrospinal fluid
OT  - Inflammation
EDAT- 2014/09/26 06:00
MHDA- 2014/09/26 06:01
PMCR- 2014/07/31
CRDT- 2014/09/26 06:00
PHST- 2014/09/26 06:00 [entrez]
PHST- 2014/09/26 06:00 [pubmed]
PHST- 2014/09/26 06:01 [medline]
PHST- 2014/07/31 00:00 [pmc-release]
AID - dee-0004-0297 [pii]
AID - 10.1159/000362164 [doi]
PST - epublish
SO  - Dement Geriatr Cogn Dis Extra. 2014 Jul 31;4(2):297-304. doi: 10.1159/000362164. 
      eCollection 2014 May.