PMID- 25254075
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140925
LR  - 20211021
IS  - 1755-8166 (Print)
IS  - 1755-8166 (Electronic)
IS  - 1755-8166 (Linking)
VI  - 7
IP  - 1
DP  - 2014
TI  - An adult B-cell precursor acute lymphoblastic leukemia with multiple secondary 
      cytogenetic aberrations.
PG  - 60
LID - 10.1186/s13039-014-0060-0 [doi]
LID - 60
AB  - BACKGROUND: We report a clinically diagnosed acute lymphoblastic leukemia (ALL) 
      with yet unreported secondary chromosomal aberrations. RESULTS: A complete 
      cytogenetic and molecular cytogenetic analysis, using GTG banding, fluorescence 
      in situ hybridization (FISH) and array-proven multicolor banding (aMCB), for a 
      female patient with clinically diagnosed ALL and immunophenotypically confirmed 
      pre-B ALL (FAB classifications), revealed the presence of a complex structural 
      rearrangement, der (2) (20qter- > 20q13.33::2q21- > 2p14::2q21 > 2qter) along 
      with t (9;22) (q34;q11), t (12;14) (q12;p12) and a monosomy of chromosome 7. 
      CONCLUSIONS: Molecular cytogenetic studies are suited best for identification and 
      characterization of chromosomal rearrangements in acute leukemia. Single case 
      reports as well as large scale studies are necessary to provide further insights 
      in karyotypic changes taking place in human malignancies.
FAU - Al-Achkar, Walid
AU  - Al-Achkar W
AD  - Department of Molecular Biology and Biotechnology, Human Genetics Division, 
      Atomic Energy Commission of Syria, P.O. Box 6091, Damascus, Syria.
FAU - Wafa, Abdulsamad
AU  - Wafa A
AD  - Department of Molecular Biology and Biotechnology, Human Genetics Division, 
      Atomic Energy Commission of Syria, P.O. Box 6091, Damascus, Syria.
FAU - Othman, Moneeb Abdullah Kassem
AU  - Othman MA
AD  - Institute of Human Genetics, Jena University Hospital, Jena, Germany.
FAU - Moassass, Faten
AU  - Moassass F
AD  - Department of Molecular Biology and Biotechnology, Human Genetics Division, 
      Atomic Energy Commission of Syria, P.O. Box 6091, Damascus, Syria.
FAU - Aljapawe, Abdulmunim
AU  - Aljapawe A
AD  - Department of Molecular Biology and Biotechnology, Mammalians Biology Division, 
      Atomic Energy Commission, Damascus, Syria.
FAU - Liehr, Thomas
AU  - Liehr T
AD  - Institute of Human Genetics, Jena University Hospital, Jena, Germany.
LA  - eng
PT  - Case Reports
DEP - 20140910
PL  - England
TA  - Mol Cytogenet
JT  - Molecular cytogenetics
JID - 101317942
PMC - PMC4172788
OTO - NOTNLM
OT  - Acute lymphoblastic leukemia
OT  - Array-proven multicolor banding
OT  - Fluorescence in situ hybridization
OT  - Philadelphia chromosome
OT  - Prognostic factors
OT  - Secondary chromosomal abnormalities
EDAT- 2014/09/26 06:00
MHDA- 2014/09/26 06:01
PMCR- 2014/09/10
CRDT- 2014/09/26 06:00
PHST- 2014/06/09 00:00 [received]
PHST- 2014/08/21 00:00 [accepted]
PHST- 2014/09/26 06:00 [entrez]
PHST- 2014/09/26 06:00 [pubmed]
PHST- 2014/09/26 06:01 [medline]
PHST- 2014/09/10 00:00 [pmc-release]
AID - 60 [pii]
AID - 10.1186/s13039-014-0060-0 [doi]
PST - epublish
SO  - Mol Cytogenet. 2014 Sep 10;7(1):60. doi: 10.1186/s13039-014-0060-0. eCollection 
      2014.