PMID- 25254522
OWN - NLM
STAT- MEDLINE
DCOM- 20151015
LR  - 20220330
IS  - 2148-5607 (Electronic)
IS  - 1300-4948 (Linking)
VI  - 25
IP  - 4
DP  - 2014 Aug
TI  - Diagnostics in cystic echinococcosis: serology versus ultrasonography.
PG  - 398-404
LID - 10.5152/tjg.2014.7112 [doi]
AB  - BACKGROUND/AIMS: Cystic echinococcosis (CE) is the most widespread zoonosis 
      worldwide. The objective of the present study was to compare diagnostic methods 
      in the work-up of suspected cystic echinococcosis of the liver. MATERIALS AND 
      METHODS: Data from a total of 68 patients were compiled and analyzed. RESULTS: A 
      diagnosis of cystic echinococcosis was made in 36.8% of patients. Broken down 
      according to WHO criteria, patients with at least one echinococcus cyst were 
      determined in 12.0% of cases to exhibit cysts consistent with stage 1 disease 
      (CE1), while in 24.0%, cysts consistent with CE2 and CE3 were identified. CE4 and 
      CE5 cysts were identified in 32.0% and 8.0% of patients, respectively. Solitary 
      cysts were found in 60.0% of patients with cystic echinococcosis, while in 
      patients with at least one cystic lesion, there were most often multiple cysts. 
      The indirect hemagglutination test (IHA) and echinococcus-specific immunoglobulin 
      E (IgE) concentration showed a higher sensitivity (60.9%, 68.4%) than did the 
      enzyme-linked immunosorbent assay (ELISA) for Echinococcus multilocularis (Em2+) 
      and total IgE (11.1%, 38.9%). The respective specificities of all four 
      serological methods lay between 83.9% and 88.9%. CONCLUSION: Our data show that 
      ultrasound remains the diagnostic method of choice in the work-up of cystic 
      lesions of the liver suspected to be due to Echinococcus granulosus. Serological 
      methods can serve an adjunctive role.
FAU - Wuestenberg, Johanna
AU  - Wuestenberg J
AD  - Department of Internal Medicine I, University Hospital Ulm, Ulm, Germany. 
      wolfgang.kratzer@uniklinik-ulm.de.
FAU - Gruener, Beate
AU  - Gruener B
FAU - Oeztuerk, Suemeyra
AU  - Oeztuerk S
FAU - Mason, Richard A
AU  - Mason RA
FAU - Haenle, Mark M
AU  - Haenle MM
FAU - Graeter, Tilmann
AU  - Graeter T
FAU - Akinli, Atilla S
AU  - Akinli AS
FAU - Kern, Peter
AU  - Kern P
FAU - Kratzer, Wolfgang
AU  - Kratzer W
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Turkey
TA  - Turk J Gastroenterol
JT  - The Turkish journal of gastroenterology : the official journal of Turkish Society 
      of Gastroenterology
JID - 9515841
RN  - 0 (Antigens, Helminth)
RN  - 0 (Em2 antigen, Echinococcus multilocularis)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Animals
MH  - Antigens, Helminth/*immunology
MH  - Echinococcosis, Hepatic/*diagnosis/diagnostic imaging
MH  - Echinococcus granulosus/*immunology
MH  - Echinococcus multilocularis/*immunology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Hemagglutination Tests
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
MH  - Serologic Tests/methods
MH  - Ultrasonography
EDAT- 2014/09/26 06:00
MHDA- 2015/10/16 06:00
CRDT- 2014/09/26 06:00
PHST- 2014/09/26 06:00 [entrez]
PHST- 2014/09/26 06:00 [pubmed]
PHST- 2015/10/16 06:00 [medline]
AID - 10.5152/tjg.2014.7112 [doi]
PST - ppublish
SO  - Turk J Gastroenterol. 2014 Aug;25(4):398-404. doi: 10.5152/tjg.2014.7112.