PMID- 25256018
OWN - NLM
STAT- MEDLINE
DCOM- 20160412
LR  - 20221207
IS  - 1873-460X (Electronic)
IS  - 1056-8727 (Linking)
VI  - 29
IP  - 1
DP  - 2015 Jan-Feb
TI  - Prevalence of microvascular diseases among tertiary care Chinese with early 
      versus late onset of type 2 diabetes.
PG  - 32-7
LID - S1056-8727(14)00256-6 [pii]
LID - 10.1016/j.jdiacomp.2014.08.010 [doi]
AB  - AIMS: This study aimed to investigate the impact of early-onset diabetes on the 
      risk of microvascular diseases in Chinese with type 2 diabetes mellitus (T2DM). 
      METHODS: A cross sectional survey of 29,442 patients with T2DM in 77 tertiary 
      hospitals in China was conducted in 2011. Early-onset diabetes was defined as 
      diagnosis of diabetes before 40years of age. Microvascular complications and risk 
      factors were documented. Prevalence of microvascular disease was standardized to 
      the Chinese population in 2010. Logistic regression analysis was performed to 
      obtain odds ratios (OR) for early versus late onset of T2DM. RESULTS: A total of 
      1,303 (4.4%) patients had nephropathy, 2,137 (7.3%) had retinopathy and 3,012 
      (10.2%) had either of them. Early-onset diabetes greatly increased the prevalence 
      of microvascular diseases compared with late-onset diabetes (nephropathy: 5.1% 
      vs. 1.5%; retinopathy: 7.1% vs. 2.7%; either: 9.7% vs. 3.6%), especially among 
      patients from 45 to 59years of age. After adjusting for age and sex, patients 
      with early-onset T2DM were at 1.69-fold (95% CI 1.46-1.95) higher risk of 
      microvascular diseases than those with late-onset T2DM. However, this was not 
      significant after adjusting for traditional risk factors and disease duration 
      (p=0.162). CONCLUSION: Chinese patients with early-onset T2DM are at a marked 
      increased risk of microvascular diseases.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Li, Ling
AU  - Li L
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Tianjin 
      Medical University, Tianjin, China.
FAU - Ji, Linong
AU  - Ji L
AD  - Department of Endocrinology and metabolism, Peking University People's Hospital, 
      Beijing, China.
FAU - Guo, Xiaohui
AU  - Guo X
AD  - Department of Endocrinology, Peking University First Hospital, Beijing, China.
FAU - Ji, Qiuhe
AU  - Ji Q
AD  - Department of Endocrinology, Xijing Hospital affiliated to 4th Military Medical 
      University, Xi'an, China.
FAU - Gu, Weijun
AU  - Gu W
AD  - Department of Endocrinology, Chinese PLA General Hospital, Beijing, China.
FAU - Zhi, Xinyue
AU  - Zhi X
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Tianjin 
      Medical University, Tianjin, China.
FAU - Li, Xing
AU  - Li X
AD  - Department of Endocrinology, The Second Hospital of Shanxi Medical University, 
      Taiyuan, China.
FAU - Kuang, Hongyu
AU  - Kuang H
AD  - Department of Endocrinology, The First Affiliated Hospital of Harbin Medical 
      University, Harbin, China.
FAU - Su, Benli
AU  - Su B
AD  - Department of Endocrinology, The Second Affiliated Hospital of Dalian Medical 
      University, Dalian, China.
FAU - Yan, Jinhua
AU  - Yan J
AD  - Department of Endocrinology, The Third Affiliated Hospital of Sun Yat-sen 
      University, Guangzhou, China.
FAU - Yang, Xilin
AU  - Yang X
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Tianjin 
      Medical University, Tianjin, China. Electronic address: yxl@hotmail.com.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20140903
PL  - United States
TA  - J Diabetes Complications
JT  - Journal of diabetes and its complications
JID - 9204583
SB  - IM
MH  - Adult
MH  - Age Distribution
MH  - *Age of Onset
MH  - Asian People/statistics & numerical data
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/diagnosis/*epidemiology
MH  - Diabetic Angiopathies/diagnosis/*epidemiology
MH  - Diabetic Nephropathies/diagnosis/*epidemiology
MH  - Diabetic Retinopathy/diagnosis/epidemiology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Odds Ratio
MH  - Prevalence
MH  - Severity of Illness Index
MH  - Sex Distribution
MH  - Tertiary Care Centers
OTO - NOTNLM
OT  - Chinese
OT  - Early-onset
OT  - Microvascular diseases
OT  - Prevalence
OT  - Type 2 diabetes mellitus
EDAT- 2014/09/27 06:00
MHDA- 2016/04/14 06:00
CRDT- 2014/09/27 06:00
PHST- 2014/06/26 00:00 [received]
PHST- 2014/08/01 00:00 [revised]
PHST- 2014/08/21 00:00 [accepted]
PHST- 2014/09/27 06:00 [entrez]
PHST- 2014/09/27 06:00 [pubmed]
PHST- 2016/04/14 06:00 [medline]
AID - S1056-8727(14)00256-6 [pii]
AID - 10.1016/j.jdiacomp.2014.08.010 [doi]
PST - ppublish
SO  - J Diabetes Complications. 2015 Jan-Feb;29(1):32-7. doi: 
      10.1016/j.jdiacomp.2014.08.010. Epub 2014 Sep 3.