PMID- 25256068
OWN - NLM
STAT- MEDLINE
DCOM- 20150202
LR  - 20211021
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Print)
IS  - 0002-9394 (Linking)
VI  - 159
IP  - 1
DP  - 2015 Jan
TI  - Reproducibility of retinal nerve fiber layer thickness measures using eye 
      tracking in children with nonglaucomatous optic neuropathy.
PG  - 71-7.e1
LID - S0002-9394(14)00619-9 [pii]
LID - 10.1016/j.ajo.2014.09.029 [doi]
AB  - PURPOSE: To determine the intra- and intervisit reproducibility of 
      circumpapillary retinal nerve fiber layer (RNFL) thickness measures using eye 
      tracking-assisted spectral-domain optical coherence tomography (SD OCT) in 
      children with nonglaucomatous optic neuropathy. DESIGN: Prospective longitudinal 
      study. METHODS: Circumpapillary RNFL thickness measures were acquired with SD OCT 
      using the eye-tracking feature at 2 separate study visits. Children with normal 
      and abnormal vision (visual acuity >/= 0.2 logMAR above normal and/or visual field 
      loss) who demonstrated clinical and radiographic stability were enrolled. Intra- 
      and intervisit reproducibility was calculated for the global average and 9 
      anatomic sectors by calculating the coefficient of variation and intraclass 
      correlation coefficient. RESULTS: Forty-two subjects (median age 8.6 years, range 
      3.9-18.2 years) met inclusion criteria and contributed 62 study eyes. Both the 
      abnormal and normal vision cohort demonstrated the lowest intravisit coefficient 
      of variation for the global RNFL thickness. Intervisit reproducibility remained 
      good for those with normal and abnormal vision, although small but statistically 
      significant increases in the coefficient of variation were observed for multiple 
      anatomic sectors in both cohorts. The magnitude of visual acuity loss was 
      significantly associated with the global (ss = 0.026, P < .01) and temporal sector 
      coefficient of variation (ss = 0.099, P < .01). CONCLUSION: SD OCT with eye 
      tracking demonstrates highly reproducible RNFL thickness measures. Subjects with 
      vision loss demonstrate greater intra- and intervisit variability than those with 
      normal vision.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Rajjoub, Raneem D
AU  - Rajjoub RD
AD  - George Washington University School of Medicine, Children's National Health 
      System, Washington, DC.
FAU - Trimboli-Heidler, Carmelina
AU  - Trimboli-Heidler C
AD  - The Gilbert Family Neurofibromatosis Institute, Children's National Health 
      System, Washington, DC.
FAU - Packer, Roger J
AU  - Packer RJ
AD  - The Gilbert Family Neurofibromatosis Institute, Children's National Health 
      System, Washington, DC; Department of Pediatrics, Children's National Health 
      System, Washington, DC; Center for Neuroscience and Behavior, Children's National 
      Health System, Washington, DC; The Brain Tumor Institute, Children's National 
      Health System, Washington, DC.
FAU - Avery, Robert A
AU  - Avery RA
AD  - The Gilbert Family Neurofibromatosis Institute, Children's National Health 
      System, Washington, DC; Department of Ophthalmology, Children's National Health 
      System, Washington, DC; Department of Pediatrics, Children's National Health 
      System, Washington, DC; Center for Neuroscience and Behavior, Children's National 
      Health System, Washington, DC. Electronic address: ravery@childrensnational.org.
LA  - eng
GR  - K23 EY022673/EY/NEI NIH HHS/United States
GR  - K23-EY022673/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20141002
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Nerve Fibers/*pathology
MH  - Optic Nerve Diseases/*pathology
MH  - Prospective Studies
MH  - Regression Analysis
MH  - Reproducibility of Results
MH  - Retinal Ganglion Cells/*pathology
MH  - Tomography, Optical Coherence/instrumentation/*methods
MH  - Visual Acuity
PMC - PMC4455020
MID - NIHMS631665
EDAT- 2014/09/27 06:00
MHDA- 2015/02/03 06:00
PMCR- 2016/01/01
CRDT- 2014/09/27 06:00
PHST- 2014/07/17 00:00 [received]
PHST- 2014/09/16 00:00 [revised]
PHST- 2014/09/18 00:00 [accepted]
PHST- 2014/09/27 06:00 [entrez]
PHST- 2014/09/27 06:00 [pubmed]
PHST- 2015/02/03 06:00 [medline]
PHST- 2016/01/01 00:00 [pmc-release]
AID - S0002-9394(14)00619-9 [pii]
AID - 10.1016/j.ajo.2014.09.029 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2015 Jan;159(1):71-7.e1. doi: 10.1016/j.ajo.2014.09.029. Epub 
      2014 Oct 2.