PMID- 25257099
OWN - NLM
STAT- MEDLINE
DCOM- 20150903
LR  - 20221207
IS  - 1523-5378 (Electronic)
IS  - 1083-4389 (Linking)
VI  - 20
IP  - 1
DP  - 2015 Feb
TI  - Correlation between Helicobacter pylori infection, IgE hypersensitivity, and 
      allergic disease in Korean adults.
PG  - 49-55
LID - 10.1111/hel.12173 [doi]
AB  - BACKGROUND: The correlation between allergic disease and Helicobacter pylori 
      infection is still controversial in endemic areas. The aim of this study was to 
      determine whether H. pylori infection is related to allergic disease and/or 
      immunoglobulin E (IgE) hypersensitivity in Korean adults. MATERIALS AND METHODS: 
      Consecutive Korean adults who visited our center for a routine checkup were 
      enrolled. All subjects completed a questionnaire that was designed to ascertain 
      their medical history pertaining to physician-diagnosed allergic disease, allergy 
      treatments, and H. pylori eradication therapy. Blood was sampled for serum 
      anti-H. pylori IgG antibody. IgE hypersensitivity was measured using a 
      commercially available ImmunoCAP((R)) Phadiatop (Phadia AB, Uppsala, Sweden). 
      RESULTS: Of the 3376 Korean adults who were enrolled, 62 did not answer to the 
      questionnaires adequately and were thus excluded. The proportion of noninfected 
      subjects (p < .001) and the prevalence of IgE-related allergic disease (p < .001) 
      were both highest among those aged <40 years, while the prevalence of 
      non-IgE-related allergic disease was highest among those aged >/=70 years 
      (p < .001). Logistic regression analysis revealed that being younger than 
      40 years was significantly related to the absence of H. pylori infection 
      (OR = 2.507, 95% CI = 1.621-3.878, p < .001). CONCLUSIONS: The statuses of 
      H. pylori infection, IgE hypersensitivity, and allergic diseases differ with age 
      group, there being a higher prevalence of IgE-related allergic disease and a 
      lower H. pylori infection rate among young adults. The hygiene hypothesis might 
      explain these findings in young Koreans, due to the rapid development and 
      improvements in sanitation in Korea.
CI  - (c) 2014 John Wiley & Sons Ltd.
FAU - Lee, Sang Pyo
AU  - Lee SP
AD  - Department of Internal Medicine, Konkuk University School of Medicine, Seoul, 
      Korea.
FAU - Lee, Sun-Young
AU  - Lee SY
FAU - Kim, Jeong Hwan
AU  - Kim JH
FAU - Sung, In-Kyung
AU  - Sung IK
FAU - Park, Hyung Seok
AU  - Park HS
FAU - Shim, Chan Sup
AU  - Shim CS
FAU - Moon, Hee-Won
AU  - Moon HW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140925
PL  - England
TA  - Helicobacter
JT  - Helicobacter
JID - 9605411
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Asian People
MH  - Cross-Sectional Studies
MH  - Female
MH  - Helicobacter Infections/*complications
MH  - Humans
MH  - Hypersensitivity/*epidemiology
MH  - Immunoglobulin E/*blood
MH  - Korea/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Surveys and Questionnaires
MH  - Young Adult
OTO - NOTNLM
OT  - Helicobacter pylori
OT  - IgE hypersensitivity
OT  - Phadiatop
OT  - allergy
OT  - eradication
EDAT- 2014/09/27 06:00
MHDA- 2015/09/04 06:00
CRDT- 2014/09/27 06:00
PHST- 2014/09/27 06:00 [entrez]
PHST- 2014/09/27 06:00 [pubmed]
PHST- 2015/09/04 06:00 [medline]
AID - 10.1111/hel.12173 [doi]
PST - ppublish
SO  - Helicobacter. 2015 Feb;20(1):49-55. doi: 10.1111/hel.12173. Epub 2014 Sep 25.