PMID- 25257393 OWN - NLM STAT- MEDLINE DCOM- 20150706 LR - 20141129 IS - 1759-9873 (Electronic) IS - 0964-5284 (Linking) VI - 32 IP - 6 DP - 2014 Dec TI - Could acupuncture have a role in the treatment of autism spectrum disorder via modulation of BDNF expression and activation? PG - 503-5 LID - 10.1136/acupmed-2014-010602 [doi] AB - Autism spectrum disorder (ASD) is a set of heterogeneous neurodevelopmental conditions characterised by early-onset difficulties in social communication and unusually restricted repetitive behaviour and interests. Multiple lines of evidence directly or indirectly suggest an involvement in autism of the brain-derived neurotrophic factor (BDNF), which plays a pivotal role in the development and plasticity of the brain. Recent studies have demonstrated the neuroprotective effect of acupuncture-induced activation of BDNF in many neurological disorders. In view of these findings, we hypothesise the potential therapeutic effect of acupuncture-induced activation of BDNF in the treatment of ASD. CI - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. FAU - Li, Li-Ya AU - Li LY AD - School of Nursing, Tianjin Medical University, Tianjin, China. FAU - Jiang, Nan AU - Jiang N AD - School of Nursing, Tianjin Medical University, Tianjin, China. FAU - Zhao, Yue AU - Zhao Y AD - School of Nursing, Tianjin Medical University, Tianjin, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20140925 PL - England TA - Acupunct Med JT - Acupuncture in medicine : journal of the British Medical Acupuncture Society JID - 9304117 RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - *Acupuncture Therapy MH - Brain/*metabolism MH - Brain-Derived Neurotrophic Factor/*metabolism MH - Child MH - Child Development Disorders, Pervasive/metabolism/*therapy MH - Humans OTO - NOTNLM OT - ACUPUNCTURE OT - NEUROPHYSIOLOGY OT - PSYCHOLOGY EDAT- 2014/09/27 06:00 MHDA- 2015/07/07 06:00 CRDT- 2014/09/27 06:00 PHST- 2014/09/27 06:00 [entrez] PHST- 2014/09/27 06:00 [pubmed] PHST- 2015/07/07 06:00 [medline] AID - acupmed-2014-010602 [pii] AID - 10.1136/acupmed-2014-010602 [doi] PST - ppublish SO - Acupunct Med. 2014 Dec;32(6):503-5. doi: 10.1136/acupmed-2014-010602. Epub 2014 Sep 25.