PMID- 25257554
OWN - NLM
STAT- MEDLINE
DCOM- 20151019
LR  - 20211021
IS  - 1559-131X (Electronic)
IS  - 1357-0560 (Linking)
VI  - 31
IP  - 11
DP  - 2014 Nov
TI  - Cisplatin and paclitaxel target significant long noncoding RNAs in laryngeal 
      squamous cell carcinoma.
PG  - 246
LID - 10.1007/s12032-014-0246-7 [doi]
AB  - The objectives of this study were to identify specific long noncoding RNAs 
      (lncRNAs) in laryngeal squamous cell carcinoma (LSCC) and to clarify the function 
      of cisplatin and paclitaxel on the confirmed laryngeal cancer lncRNAs. Fifty-four 
      pairs of laryngeal tumor and adjacent normal tissue were collected. Candidate 
      lncRNAs were searched in authorized databases. The significant lncRNAs were 
      identified and confirmed through high-output real-time PCR. Chemotherapy assay 
      evaluated the influences of cisplatin and paclitaxel on the significant lncRNAs. 
      Thirty-seven cancer-related candidate lncRNAs were selected. Three up-expressed 
      and two down-expressed significant lncRNAs were identified and confirmed. The 
      expressions of lncRNA CDKN2B-AS1, HOTAIR and MALAT1 were dramatically reduced 
      with the increasing concentration of cisplatin and paclitaxel and also 
      lengthening of the treatment duration. Cisplatin and paclitaxel have target 
      function on significant lncRNAs in LSCC, which presents novel molecular targets 
      to cure LSCC patients and also leads an orientation for developing new drugs.
FAU - Chen, Hui
AU  - Chen H
AD  - Department of Otolaryngology-Head and Neck Surgery, Affiliated Eye and ENT 
      Hospital of Fudan University, #83, Fenyang Road, Shanghai, 200031, China.
FAU - Xin, Yuan
AU  - Xin Y
FAU - Zhou, Liang
AU  - Zhou L
FAU - Huang, Jia-meng
AU  - Huang JM
FAU - Tao, Lei
AU  - Tao L
FAU - Cheng, Lei
AU  - Cheng L
FAU - Tian, Jie
AU  - Tian J
LA  - eng
PT  - Journal Article
DEP - 20140926
PL  - United States
TA  - Med Oncol
JT  - Medical oncology (Northwood, London, England)
JID - 9435512
RN  - 0 (RNA, Long Noncoding)
RN  - P88XT4IS4D (Paclitaxel)
RN  - Q20Q21Q62J (Cisplatin)
SB  - IM
MH  - Aged
MH  - Carcinoma, Squamous Cell/drug therapy/genetics/*metabolism
MH  - Cell Line, Tumor
MH  - Cisplatin/*administration & dosage
MH  - *Drug Delivery Systems/methods
MH  - Female
MH  - Head and Neck Neoplasms/drug therapy/genetics/*metabolism
MH  - Humans
MH  - Laryngeal Neoplasms/drug therapy/genetics/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Paclitaxel/*administration & dosage
MH  - RNA, Long Noncoding/antagonists & inhibitors/*biosynthesis/genetics
MH  - Squamous Cell Carcinoma of Head and Neck
EDAT- 2014/09/27 06:00
MHDA- 2015/10/20 06:00
CRDT- 2014/09/27 06:00
PHST- 2014/09/01 00:00 [received]
PHST- 2014/09/12 00:00 [accepted]
PHST- 2014/09/27 06:00 [entrez]
PHST- 2014/09/27 06:00 [pubmed]
PHST- 2015/10/20 06:00 [medline]
AID - 10.1007/s12032-014-0246-7 [doi]
PST - ppublish
SO  - Med Oncol. 2014 Nov;31(11):246. doi: 10.1007/s12032-014-0246-7. Epub 2014 Sep 26.