PMID- 25257604
OWN - NLM
STAT- MEDLINE
DCOM- 20161014
LR  - 20161230
IS  - 1863-2661 (Electronic)
IS  - 1863-2653 (Linking)
VI  - 221
IP  - 1
DP  - 2016 Jan
TI  - Adolescent nicotine-induced dendrite remodeling in the nucleus accumbens is 
      rapid, persistent, and D1-dopamine receptor dependent.
PG  - 133-45
LID - 10.1007/s00429-014-0897-3 [doi]
AB  - Chronic nicotine exposure during adolescence induces dendritic remodeling of 
      medium spiny neurons (MSNs) in the nucleus accumbens (NAcc) shell. While 
      nicotine-induced dendritic remodeling has frequently been described as 
      persistent, the trajectory of dendrite remodeling is unknown. Specifically, no 
      study to date has characterized the structural plasticity of dendrites in the 
      NAcc immediately following chronic nicotine, leaving open the possibility that 
      dendrite remodeling emerges gradually over time. Further, the 
      neuropharmacological mechanisms through which nicotine induces dendrite 
      remodeling are not well understood. To address these questions, rats were 
      co-administered chronic nicotine (0.5 mg/kg) and the D1-dopamine receptor (D1DR) 
      antagonist SCH-23390 (0.05 mg/kg) subcutaneously every other day during 
      adolescence. Brains were then processed for Golgi-Cox staining either 1 day or 
      21 days following drug exposure and dendrites from MSNs in the NAcc shell 
      digitally reconstructed in 3D. Spine density was also measured at both time 
      points. Our morphometric results show (1) the formation of new dendritic branches 
      and spines 1 day following nicotine exposure, (2) new dendritic branches, but not 
      spine density, remains relatively stable for at least 21 days, (3) the 
      co-administration of SCH-23390 completely blocked nicotine-induced dendritic 
      remodeling of MSNs at both early and late time points, suggesting the formation 
      of new dendritic branches in response to nicotine is D1DR-dependent, and (4) 
      SCH-23390 failed to block nicotine-induced increases in spine density. Overall 
      this study provides new insight into how nicotine influences the normal 
      trajectory of adolescent brain development and demonstrates a persistent form of 
      nicotine-induced neuroplasticity in the NAcc shell that develops rapidly and is 
      D1DR dependent.
FAU - Ehlinger, D G
AU  - Ehlinger DG
AD  - Department of Psychology, George Mason University, Fairfax, USA. 
      dehlinge@gmu.edu.
FAU - Bergstrom, H C
AU  - Bergstrom HC
AD  - Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol 
      Abuse and Alcoholism, NIH, Rockville, USA.
FAU - Burke, J C
AU  - Burke JC
AD  - Department of Psychology, George Mason University, Fairfax, USA.
FAU - Fernandez, G M
AU  - Fernandez GM
AD  - Department of Psychology, George Mason University, Fairfax, USA.
FAU - McDonald, C G
AU  - McDonald CG
AD  - Department of Psychology, George Mason University, Fairfax, USA.
FAU - Smith, R F
AU  - Smith RF
AD  - Department of Psychology, George Mason University, Fairfax, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140926
PL  - Germany
TA  - Brain Struct Funct
JT  - Brain structure & function
JID - 101282001
RN  - 0 (Benzazepines)
RN  - 0 (Receptors, Dopamine D1)
RN  - 0 (SCH 23390)
RN  - 6M3C89ZY6R (Nicotine)
SB  - IM
MH  - Animals
MH  - Benzazepines/administration & dosage
MH  - Dendrites/*drug effects/*physiology
MH  - Male
MH  - Neuronal Plasticity/*drug effects
MH  - Nicotine/*administration & dosage
MH  - Nucleus Accumbens/cytology/*drug effects/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Dopamine D1/antagonists & inhibitors/*physiology
OTO - NOTNLM
OT  - Adolescence
OT  - D1 receptor
OT  - Dendrite morphology
OT  - Dendritic spine
OT  - Dopamine
OT  - Nicotine
EDAT- 2014/09/27 06:00
MHDA- 2016/10/16 06:00
CRDT- 2014/09/27 06:00
PHST- 2014/04/25 00:00 [received]
PHST- 2014/09/19 00:00 [accepted]
PHST- 2014/09/27 06:00 [entrez]
PHST- 2014/09/27 06:00 [pubmed]
PHST- 2016/10/16 06:00 [medline]
AID - 10.1007/s00429-014-0897-3 [pii]
AID - 10.1007/s00429-014-0897-3 [doi]
PST - ppublish
SO  - Brain Struct Funct. 2016 Jan;221(1):133-45. doi: 10.1007/s00429-014-0897-3. Epub 
      2014 Sep 26.