PMID- 25257866
OWN - NLM
STAT- MEDLINE
DCOM- 20150805
LR  - 20211021
IS  - 1522-1601 (Electronic)
IS  - 8750-7587 (Print)
IS  - 0161-7567 (Linking)
VI  - 117
IP  - 11
DP  - 2014 Dec 1
TI  - A single bout of high-intensity aerobic exercise facilitates response to paired 
      associative stimulation and promotes sequence-specific implicit motor learning.
PG  - 1325-36
LID - 10.1152/japplphysiol.00498.2014 [doi]
AB  - The objectives of the present study were to evaluate the impact of a single bout 
      of high-intensity aerobic exercise on 1) long-term potentiation (LTP)-like 
      neuroplasticity via response to paired associative stimulation (PAS) and 2) the 
      temporal and spatial components of sequence-specific implicit motor learning. 
      Additionally, relationships between exercise-induced increases in systemic 
      brain-derived neurotrophic factor (BDNF) and response to PAS and motor learning 
      were evaluated. Sixteen young healthy participants completed six experimental 
      sessions, including the following: 1) rest followed by PAS; 2) aerobic exercise 
      followed by PAS; 3) rest followed by practice of a continuous tracking (CT) task 
      and 4) a no-exercise 24-h retention test; and 5) aerobic exercise followed by CT 
      task practice and 6) a no-exercise 24-h retention test. The CT task included an 
      embedded repeated sequence allowing for evaluation of sequence-specific implicit 
      learning. Slope of motor-evoked potential recruitment curves generated with 
      transcranial magnetic stimulation showed larger increases when PAS was preceded 
      by aerobic exercise (59.8% increase) compared with rest (14.2% increase, P = 
      0.02). Time lag of CT task performance on the repeated sequence improved under 
      the aerobic exercise condition from early (-100.8 ms) to late practice (-75.2 ms, 
      P < 0.001) and was maintained at retention (-79.2 ms, P = 0.004) but did not 
      change under the rest condition (P > 0.16). Systemic BDNF increased on average by 
      3.4-fold following aerobic exercise (P = 0.003), but the changes did not relate 
      to neurophysiological or behavioral measures (P > 0.42). These results indicate 
      that a single bout of high-intensity aerobic exercise can prime LTP-like 
      neuroplasticity and promote sequence-specific implicit motor learning.
CI  - Copyright (c) 2014 the American Physiological Society.
FAU - Mang, Cameron S
AU  - Mang CS
AD  - Graduate Program in Rehabilitation Sciences, Faculty of Medicine, University of 
      British Columbia, Vancouver, Canada;
FAU - Snow, Nicholas J
AU  - Snow NJ
AD  - Graduate Program in Rehabilitation Sciences, Faculty of Medicine, University of 
      British Columbia, Vancouver, Canada;
FAU - Campbell, Kristin L
AU  - Campbell KL
AD  - Graduate Program in Rehabilitation Sciences, Faculty of Medicine, University of 
      British Columbia, Vancouver, Canada;
FAU - Ross, Colin J D
AU  - Ross CJ
AD  - Department of Pediatrics, Faculty of Medicine, University of British Columbia, 
      Vancouver, Canada; Department of Medical Genetics, Faculty of Medicine, 
      University of British Columbia, Vancouver, Canada;
FAU - Boyd, Lara A
AU  - Boyd LA
AD  - Graduate Program in Rehabilitation Sciences, Faculty of Medicine, University of 
      British Columbia, Vancouver, Canada; Graduate Program in Neuroscience, Faculty of 
      Medicine, University of British Columbia, Vancouver, Canada lara.boyd@ubc.ca.
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140925
PL  - United States
TA  - J Appl Physiol (1985)
JT  - Journal of applied physiology (Bethesda, Md. : 1985)
JID - 8502536
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Association Learning/*physiology
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Exercise/*physiology
MH  - Female
MH  - Healthy Volunteers
MH  - Humans
MH  - Male
MH  - Motor Skills/physiology
MH  - *Neuronal Plasticity
MH  - Young Adult
PMC - PMC4254838
OTO - NOTNLM
OT  - aerobic exercise
OT  - brain-derived neurotrophic factor
OT  - motor learning
OT  - neuroplasticity
EDAT- 2014/09/27 06:00
MHDA- 2015/08/06 06:00
PMCR- 2015/12/01
CRDT- 2014/09/27 06:00
PHST- 2014/09/27 06:00 [entrez]
PHST- 2014/09/27 06:00 [pubmed]
PHST- 2015/08/06 06:00 [medline]
PHST- 2015/12/01 00:00 [pmc-release]
AID - japplphysiol.00498.2014 [pii]
AID - JAPPL-00498-2014 [pii]
AID - 10.1152/japplphysiol.00498.2014 [doi]
PST - ppublish
SO  - J Appl Physiol (1985). 2014 Dec 1;117(11):1325-36. doi: 
      10.1152/japplphysiol.00498.2014. Epub 2014 Sep 25.