PMID- 2525971
OWN - NLM
STAT- MEDLINE
DCOM- 19890814
LR  - 20190918
IS  - 0730-0077 (Print)
IS  - 0730-0077 (Linking)
VI  - 11 Suppl 1
DP  - 1989
TI  - Changes of plasma noradrenaline levels in the renal and systemic circulation 
      after successful percutaneous transluminal angioplasty in renovascular 
      hypertension.
PG  - 449-58
AB  - The sympathetic nervous system involvement in the pathogenesis of human 
      renovascular hypertension was studied in 10 hypertensive patients with unilateral 
      renal artery stenosis, who underwent percutaneous transluminal angioplasty (PTA). 
      Before PTA, systolic/diastolic BP readings were 185.3 +/- 7.8/123.2 +/- 5.1 mmHg, 
      peripheral PRA values were 8.63 +/- 2.27 ngAl/ml/h, the ratio RVRR was 2.15 +/- 
      0.27, the ratio V1-IVC/IVC was 1.00 +/- 0.23 (V1 = PRA from the renal vein of the 
      stenotic side, IVC = PRA from the inferior vena cava) and the ratio V2-IVC/IVC 
      was 0.04 +/- 0.02 (V2 = PRA from the renal vein of the non-stenotic side); 30 min 
      after successful PTA the respective values of the above measured parameters were: 
      144.2 +/- 6.7/98.2 +/- 3.1 mmHg (p less than 0.01), 8.13 +/- 2.21 ngAl/ml/h (p 
      less than 0.005), 1.79 +/- 0.19 (p less than 0.01), 0.68 +/- 0.18 (p less than 
      0.001) and 0.06 +/- 0.02 (p less than 0.005). Peripheral plasma noradrenaline 
      levels (plNA) were 0.694 +/- 0.058 ng/ml, plNA levels from the renal vein of the 
      stenotic side were 0.962 +/- 0.108 ng/ml and plNA levels from the renal vein of 
      the non-stenotic side were 0.759 +/- 0.092 ng/ml; 30 min after successful PTA the 
      respective values were 0.518 +/- 0.055 ng/ml (p less than 0.01), 0.681 +/- 0.078 
      ng/ml (p less than 0.005) and 0.510 +/- 0.063 ng/ml (p less than 0.005). It is 
      suggested that the reversal of chronic renal ischaemia by PTA induced 
      statistically significant changes in the sympathetic nervous system activity, 
      parallel to the changes of renin secretion.
FAU - Zamboulis, C
AU  - Zamboulis C
AD  - B'Propedeutic Department of Internal Medicine, Aristotelian University of 
      Thessaloniki, Greece.
FAU - Karagiannis, A
AU  - Karagiannis A
FAU - Douma, S
AU  - Douma S
FAU - Vogiatzis, K
AU  - Vogiatzis K
FAU - Doumas, M
AU  - Doumas M
FAU - Byzantiades, A
AU  - Byzantiades A
FAU - Metaxas, P
AU  - Metaxas P
FAU - Efremidis, S
AU  - Efremidis S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Exp Hypertens A
JT  - Clinical and experimental hypertension. Part A, Theory and practice
JID - 8207790
RN  - EC 3.4.23.15 (Renin)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Angioplasty, Balloon
MH  - *Blood Circulation
MH  - Blood Pressure
MH  - Humans
MH  - Hypertension, Renovascular/*blood/therapy
MH  - Middle Aged
MH  - Norepinephrine/*blood
MH  - *Renal Circulation
MH  - Renin/blood
EDAT- 1989/01/01 00:00
MHDA- 1989/01/01 00:01
CRDT- 1989/01/01 00:00
PHST- 1989/01/01 00:00 [pubmed]
PHST- 1989/01/01 00:01 [medline]
PHST- 1989/01/01 00:00 [entrez]
AID - 10.3109/10641968909045453 [doi]
PST - ppublish
SO  - Clin Exp Hypertens A. 1989;11 Suppl 1:449-58. doi: 10.3109/10641968909045453.