PMID- 25260568
OWN - NLM
STAT- MEDLINE
DCOM- 20160126
LR  - 20150406
IS  - 2210-741X (Electronic)
IS  - 2210-7401 (Linking)
VI  - 39
IP  - 2
DP  - 2015 Apr
TI  - Steatotic hepatocellular adenomas with different phenotypic subtypes: a case 
      report.
PG  - e17-22
LID - S2210-7401(14)00209-5 [pii]
LID - 10.1016/j.clinre.2014.08.007 [doi]
AB  - Hepatocellular adenomas (HCAs) are heterogeneous group of benign tumors; three 
      pathomolecular subtypes have been identified so far: hepatocyte nuclear factor 1 
      alpha-inactivated HCA (H-HCA) (35-40%), inflammatory HCA (I-HCA) (>50%), beta-catenin 
      activated HCA (10%). Ten percent of I-HCA are also beta-catenin activated. We report 
      a rare case of three histologically confirmed steatotic HCAs of three different 
      phenotypes: I-HCA, beta-catenin activated I-HCA, and H-HCA in a 36-year-old woman. 
      This observation outlines that in the same patient, HCA may be of different 
      subtypes. The predisposition to develop different HCA hypothetically caused by a 
      "benign tumorigenic field effect" may result, even rarely, in different 
      genotypes/phenotypes such as H-HCA and I-HCA. Moreover, we illustrate the very 
      high specificity of MR for subtyping HCA.
CI  - Copyright (c) 2014 Elsevier Masson SAS. All rights reserved.
FAU - Alberti, N
AU  - Alberti N
AD  - Department of Radiology, hopital St-Andre, CHU de Bordeaux, 1, rue Jean-Burguet, 
      33000 Bordeaux, France. Electronic address: nicoalbertibdx@gmail.com.
FAU - Castain, C
AU  - Castain C
AD  - Department of Pathology, hopital Pellegrin, CHU de Bordeaux, place 
      Amelie-Raba-Leon, 33000 Bordeaux, France.
FAU - Crombe, A
AU  - Crombe A
AD  - Department of Radiology, hopital St-Andre, CHU de Bordeaux, 1, rue Jean-Burguet, 
      33000 Bordeaux, France.
FAU - Frulio, N
AU  - Frulio N
AD  - Department of Radiology, hopital St-Andre, CHU de Bordeaux, 1, rue Jean-Burguet, 
      33000 Bordeaux, France.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20140926
PL  - France
TA  - Clin Res Hepatol Gastroenterol
JT  - Clinics and research in hepatology and gastroenterology
JID - 101553659
SB  - IM
MH  - Adenoma, Liver Cell/complications/*genetics
MH  - Adult
MH  - Fatty Liver/complications
MH  - Female
MH  - Humans
MH  - Liver Neoplasms/complications/*genetics
EDAT- 2014/09/28 06:00
MHDA- 2016/01/27 06:00
CRDT- 2014/09/28 06:00
PHST- 2014/05/20 00:00 [received]
PHST- 2014/07/18 00:00 [revised]
PHST- 2014/08/18 00:00 [accepted]
PHST- 2014/09/28 06:00 [entrez]
PHST- 2014/09/28 06:00 [pubmed]
PHST- 2016/01/27 06:00 [medline]
AID - S2210-7401(14)00209-5 [pii]
AID - 10.1016/j.clinre.2014.08.007 [doi]
PST - ppublish
SO  - Clin Res Hepatol Gastroenterol. 2015 Apr;39(2):e17-22. doi: 
      10.1016/j.clinre.2014.08.007. Epub 2014 Sep 26.