PMID- 25261574
OWN - NLM
STAT- MEDLINE
DCOM- 20160406
LR  - 20220317
IS  - 1468-2060 (Electronic)
IS  - 0003-4967 (Linking)
VI  - 75
IP  - 1
DP  - 2016 Jan
TI  - Certain class I HLA alleles and haplotypes implicated in susceptibility play a 
      role in determining specific features of the psoriatic arthritis phenotype.
PG  - 155-62
LID - 10.1136/annrheumdis-2014-205461 [doi]
AB  - OBJECTIVES: Psoriatic arthritis (PsA) susceptibility is associated with several 
      different class I alleles, suggesting separate patterns of MHC effect. This 
      exploratory study was based on the hypothesis that heterogeneity of the clinical 
      phenotype of PsA might be explained by differing associations of clinical 
      features with these susceptibility genes. METHODS: The clinical phenotype of 282 
      PsA patients in a cohort previously studied for associations with human leukocyte 
      antigen (HLA)-B and HLA-C genotypes was first preliminarily assessed by 
      univariate associations of susceptibility genes with specific clinical 
      characteristics. To explore the potential genotypic effects of pairwise 
      combinations of different HLA-B and C alleles/haplotypes, we created a series of 
      allele/haplotype risk scores combining single alleles/haplotypes separately 
      associated with being in the highest PsA severity propensity tertile based on the 
      features studied by univariate analysis. RESULTS: In exploratory univariate 
      analyses, B*27:05:02 was positively associated with enthesitis, dactylitis and 
      symmetric sacroiliitis, whereas B*08:01:01-C*07:01:01and its component alleles 
      were positively associated with joint fusion and deformities, asymmetrical 
      sacroiliitis, and dactylitis. HLA-C*06:02:01 was negatively associated with 
      asymmetrical sacroiliitis. The highest propensity score for severe PsA was with 
      B*27:05:02-C*02:02:02, B*08:01:01-C*07:01:01 and B*37:01:01-C*06:02:01, but not 
      the B*27:05:02-C*01:01:01 or B*57:01:01-C*06:02:01 haplotypes. In contrast, B*44 
      haplotypes were associated with presence of milder disease, and in univariate 
      analysis with a decreased frequency of enthesitis, joint fusion, deformities and 
      dactylitis. CONCLUSIONS: Different HLA susceptibility genes were associated with 
      particular features that defined the PsA phenotype of a given patient. Additive 
      interactions between different susceptibility HLA alleles defined the propensity 
      for a more severe or milder musculoskeletal phenotype.
CI  - Published by the BMJ Publishing Group Limited. For permission to use (where not 
      already granted under a licence) please go to 
      http://www.bmj.com/company/products-services/rights-and-licensing/
FAU - Haroon, Muhammad
AU  - Haroon M
AD  - Department of Rheumatology, St Vincent's University Hospital, Dublin, Ireland.
FAU - Winchester, Robert
AU  - Winchester R
AD  - Division of Rheumatology, Columbia University, College of Physicians and 
      Surgeons, New York, New York, USA.
FAU - Giles, Jon T
AU  - Giles JT
AD  - Division of Rheumatology, Columbia University, College of Physicians and 
      Surgeons, New York, New York, USA.
FAU - Heffernan, Eric
AU  - Heffernan E
AD  - Department of Diagnostic Imaging, St Vincent's University Hospital, Dublin, 
      Ireland.
FAU - FitzGerald, Oliver
AU  - FitzGerald O
AD  - Department of Rheumatology, St Vincent's University Hospital, Dublin, Ireland.
LA  - eng
PT  - Journal Article
DEP - 20140926
PL  - England
TA  - Ann Rheum Dis
JT  - Annals of the rheumatic diseases
JID - 0372355
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Arthritis, Psoriatic/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - HLA-B Antigens/genetics
MH  - HLA-C Antigens/genetics
MH  - Haplotypes
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Phenotype
MH  - Propensity Score
MH  - Severity of Illness Index
OTO - NOTNLM
OT  - Gene Polymorphism
OT  - Inflammation
OT  - Psoriatic Arthritis
EDAT- 2014/09/28 06:00
MHDA- 2016/04/07 06:00
CRDT- 2014/09/28 06:00
PHST- 2014/02/23 00:00 [received]
PHST- 2014/09/13 00:00 [accepted]
PHST- 2014/09/28 06:00 [entrez]
PHST- 2014/09/28 06:00 [pubmed]
PHST- 2016/04/07 06:00 [medline]
AID - annrheumdis-2014-205461 [pii]
AID - 10.1136/annrheumdis-2014-205461 [doi]
PST - ppublish
SO  - Ann Rheum Dis. 2016 Jan;75(1):155-62. doi: 10.1136/annrheumdis-2014-205461. Epub 
      2014 Sep 26.