PMID- 25262074
OWN - NLM
STAT- MEDLINE
DCOM- 20150209
LR  - 20141209
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 135
DP  - 2014 Nov
TI  - Blood pressure in relation to contamination by polychlorobiphenyls and 
      organochlorine pesticides: Results from a population-based study in the Canary 
      Islands (Spain).
PG  - 48-54
LID - S0013-9351(14)00286-2 [pii]
LID - 10.1016/j.envres.2014.05.036 [doi]
AB  - BACKGROUND: Epidemiological studies have reported significant associations 
      between exposure to persistent organic pollutants (POPs) and increased blood 
      pressure (BP). Environmental exposure to POPs, mainly organochlorine pesticides, 
      is of concern to the population of the Canary Islands, who display a high 
      prevalence of diseases associated with hypertension such as metabolic syndrome, 
      obesity and cardiovascular disease. OBJECTIVE: We performed this population-based 
      study in a representative population sample from this archipelago to evaluate 
      whether serum levels of selected POPs could be considered as hypertension risk 
      factors. METHODS: BP and several other well-known factors related to hypertension 
      (gender, age, smoking, BMI, and total lipids) were recorded in 428 adult 
      participants from the Canary Islands Nutritional Survey. In total, 28 POPs 
      (including 18 polychlorinated biphenyl (PCB) congeners and 10 organochlorine 
      pesticides and metabolites) were measured in the serum of the population enrolled 
      in this survey. RESULTS: In total, 167 subjects (39%) demonstrated hypertension 
      or used antihypertensive medication. We observed a positive association between 
      systolic and diastolic BP and p,p'-DDE (r=0.222; p<0.001, and r=0.123; p=0.015, 
      respectively). Conversely, an inverse association between systolic BP and aldrin 
      was observed (r=-0.120; p=0.017). After adjusting for known confounders, only 
      aldrin was inversely related to hypertension risk [OR: 0.28 (95% CI: 0.09-0.92); 
      p=0.037]. After excluding subjects undergoing anti-hypertensive treatment, we 
      also observed that aldrin was inversely associated with systolic BP in 
      multivariate analyses, especially in men [OR: 0.126 (95% CI: 0.021-0.763); 
      p=0.024]. CONCLUSION: Although it has been postulated that background POPs 
      exposure may play a relevant role on elevated BP, we did not observed increased 
      hypertension risk in relation to serum POPs in this cross-sectional study. 
      Conversely, the cyclodiene pesticide aldrin was negatively associated with 
      hypertension, suggesting that cyclodienes could exert an effect opposite of the 
      DDT metabolites. These findings agree with other previous works indicating that 
      POPs may induce divergent actions on BP and suggest that the direction of the 
      association between BP and POPs could be dependent on the chemical structure as 
      well as concentration of the evaluated POP. Prospective studies are needed to 
      clarify the effect exerted by POPs on BP.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Henriquez-Hernandez, Luis A
AU  - Henriquez-Hernandez LA
AD  - Toxicology Unit, Clinical Sciences Department, Universidad de Las Palmas de Gran 
      Canaria (Spain), Instituto Canario de Investigacion del Cancer (ICIC), and 
      Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition 
      (CIBERObn), Plaza Dr. Pasteur s/n, 35016 Las Palmas de Gran Canaria, Spain; 
      Radiation Oncology Department, Hospital Universitario de Gran Canaria Dr Negrin, 
      Las Palmas de Gran Canaria, Spain.
FAU - Luzardo, Octavio P
AU  - Luzardo OP
AD  - Toxicology Unit, Clinical Sciences Department, Universidad de Las Palmas de Gran 
      Canaria (Spain), Instituto Canario de Investigacion del Cancer (ICIC), and 
      Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition 
      (CIBERObn), Plaza Dr. Pasteur s/n, 35016 Las Palmas de Gran Canaria, Spain.
FAU - Zumbado, Manuel
AU  - Zumbado M
AD  - Toxicology Unit, Clinical Sciences Department, Universidad de Las Palmas de Gran 
      Canaria (Spain), Instituto Canario de Investigacion del Cancer (ICIC), and 
      Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition 
      (CIBERObn), Plaza Dr. Pasteur s/n, 35016 Las Palmas de Gran Canaria, Spain.
FAU - Camacho, Maria
AU  - Camacho M
AD  - Toxicology Unit, Clinical Sciences Department, Universidad de Las Palmas de Gran 
      Canaria (Spain), Instituto Canario de Investigacion del Cancer (ICIC), and 
      Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition 
      (CIBERObn), Plaza Dr. Pasteur s/n, 35016 Las Palmas de Gran Canaria, Spain.
FAU - Serra-Majem, Lluis
AU  - Serra-Majem L
AD  - Preventive Medicine Unit, Clinical Sciences Department, Universidad de Las Palmas 
      de Gran Canaria, Instituto Canario de Investigacion del Cancer (ICIC), and 
      Spanish Biomedical Research Centre in the Physiopathology of Obesity and 
      Nutrition (CIBERObn), Las Palmas de Gran Canaria, Spain.
FAU - Alvarez-Leon, Eva E
AU  - Alvarez-Leon EE
AD  - Preventive Medicine Unit, Clinical Sciences Department, Universidad de Las Palmas 
      de Gran Canaria, Instituto Canario de Investigacion del Cancer (ICIC), and 
      Spanish Biomedical Research Centre in the Physiopathology of Obesity and 
      Nutrition (CIBERObn), Las Palmas de Gran Canaria, Spain; Preventive Medicine 
      Service, Complejo Hospitalario Universitario Insular-Materno Infantil, Canary 
      Health Service, Las Palmas de Gran Canaria, Spain.
FAU - Boada, Luis D
AU  - Boada LD
AD  - Toxicology Unit, Clinical Sciences Department, Universidad de Las Palmas de Gran 
      Canaria (Spain), Instituto Canario de Investigacion del Cancer (ICIC), and 
      Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition 
      (CIBERObn), Plaza Dr. Pasteur s/n, 35016 Las Palmas de Gran Canaria, Spain. 
      Electronic address: luis.boada@ulpgc.es.
LA  - eng
PT  - Journal Article
DEP - 20140928
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticides)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adult
MH  - Environmental Exposure/*analysis
MH  - Female
MH  - Humans
MH  - Hydrocarbons, Chlorinated/blood/*toxicity
MH  - Hypertension/*chemically induced/*epidemiology
MH  - Male
MH  - Middle Aged
MH  - Pesticides/blood/*toxicity
MH  - Polychlorinated Biphenyls/blood/*toxicity
MH  - Prevalence
MH  - Risk Factors
MH  - Spain/epidemiology
OTO - NOTNLM
OT  - Blood pressure
OT  - Canary Islands
OT  - Organochlorine pesticides
OT  - Persistent organic pollutants
OT  - Polychlorinated biphenyls
EDAT- 2014/09/30 06:00
MHDA- 2015/02/11 06:00
CRDT- 2014/09/29 06:00
PHST- 2014/03/24 00:00 [received]
PHST- 2014/05/16 00:00 [revised]
PHST- 2014/05/26 00:00 [accepted]
PHST- 2014/09/29 06:00 [entrez]
PHST- 2014/09/30 06:00 [pubmed]
PHST- 2015/02/11 06:00 [medline]
AID - S0013-9351(14)00286-2 [pii]
AID - 10.1016/j.envres.2014.05.036 [doi]
PST - ppublish
SO  - Environ Res. 2014 Nov;135:48-54. doi: 10.1016/j.envres.2014.05.036. Epub 2014 Sep 
      28.