PMID- 25262572 OWN - NLM STAT- MEDLINE DCOM- 20150720 LR - 20211021 IS - 1873-6823 (Electronic) IS - 0741-8329 (Print) IS - 0741-8329 (Linking) VI - 48 IP - 7 DP - 2014 Nov TI - Genetic and behavioral determinants of hippocampal volume recovery during abstinence from alcohol. PG - 631-8 LID - S0741-8329(14)00151-7 [pii] LID - 10.1016/j.alcohol.2014.08.007 [doi] AB - Alcohol-dependent individuals (ALC) have smaller hippocampi and poorer neurocognition than healthy controls. Results from studies on the association between alcohol consumption and hippocampal volume have been mixed, suggesting that comorbid or premorbid factors (i.e., those present prior to the initiation of alcohol dependence) determine hippocampal volume in ALC. We aimed to characterize the effects of select comorbid (i.e., cigarette smoking) and premorbid factors (brain-derived neurotrophic factor [BDNF] genotype [Val66Met rs6265]) on hippocampal volume in an ALC cohort followed longitudinally into extended abstinence. One hundred twenty-one adult ALC in treatment (76 smokers, 45 non-smokers) and 35 non-smoking light-drinking controls underwent quantitative magnetic resonance imaging, BDNF genotyping, and neurocognitive assessments. Representative subgroups were studied at 1 week, 1 month, and at an average of 7 months of abstinence. ALC had smaller hippocampi than healthy controls at all time points. Hippocampal volume at 1 month of abstinence correlated with lower visuospatial function. Smoking status did not influence hippocampal volume or hippocampal volume recovery during abstinence. However, only BDNF Val homozygotes tended to have hippocampal volume increases over 7 months of abstinence, and Val homozygotes had significantly larger hippocampi than Met carriers at 7 months of abstinence. These findings suggest that BDNF genotype, but not smoking status or measures of drinking severity, regulate functionally relevant hippocampal volume recovery in abstinent ALC. Future studies aimed at exploring genetic determinants of brain morphometry in ALC may need to evaluate individuals during extended abstinence after the acute environmental effects of chronic alcohol consumption have waned. CI - Copyright (c) 2014 Elsevier Inc. All rights reserved. FAU - Hoefer, Michael E AU - Hoefer ME AD - Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA; Center for Imaging of Neurodegenerative Diseases, Veterans Administration Medical Center, San Francisco, CA, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA. FAU - Pennington, David L AU - Pennington DL AD - Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA; Center for Imaging of Neurodegenerative Diseases, Veterans Administration Medical Center, San Francisco, CA, USA. FAU - Durazzo, Timothy C AU - Durazzo TC AD - Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA; Center for Imaging of Neurodegenerative Diseases, Veterans Administration Medical Center, San Francisco, CA, USA. FAU - Mon, Anderson AU - Mon A AD - School of Applied Sciences and Statistics, Koforidua Polytechnic, Ghana. FAU - Abe, Christoph AU - Abe C AD - Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden. FAU - Truran, Diana AU - Truran D AD - Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA; Center for Imaging of Neurodegenerative Diseases, Veterans Administration Medical Center, San Francisco, CA, USA. FAU - Hutchison, Kent E AU - Hutchison KE AD - The Center for Health & Addiction: Neuroscience, Genes, & Environment, Department of Psychology and Neuroscience, University of Colorado, Boulder, CO, USA. FAU - Meyerhoff, Dieter J AU - Meyerhoff DJ AD - Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA; Center for Imaging of Neurodegenerative Diseases, Veterans Administration Medical Center, San Francisco, CA, USA. Electronic address: dieter.meyerhoff@ucsf.edu. LA - eng GR - AA10788/AA/NIAAA NIH HHS/United States GR - R21 DA025202/DA/NIDA NIH HHS/United States GR - DA24136/DA/NIDA NIH HHS/United States GR - R01 AA010788/AA/NIAAA NIH HHS/United States GR - DA025202/DA/NIDA NIH HHS/United States GR - K01 DA024136/DA/NIDA NIH HHS/United States GR - R25 MH060482/MH/NIMH NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20140827 PL - United States TA - Alcohol JT - Alcohol (Fayetteville, N.Y.) JID - 8502311 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 7171WSG8A2 (BDNF protein, human) SB - IM MH - *Alcohol Abstinence/psychology MH - Alcoholism/genetics/*pathology/psychology MH - Brain-Derived Neurotrophic Factor/genetics MH - Case-Control Studies MH - Female MH - Genotype MH - Hippocampus/drug effects/*pathology MH - Humans MH - Longitudinal Studies MH - Magnetic Resonance Imaging MH - Male MH - Middle Aged MH - Neuroimaging MH - Neuropsychological Tests MH - Organ Size/drug effects MH - Polymorphism, Single Nucleotide/genetics MH - Smoking/adverse effects PMC - PMC4266697 MID - NIHMS635055 OTO - NOTNLM OT - Alcohol OT - BDNF OT - Genetics OT - Hippocampus OT - MRI OT - Smoking COIS- No author reports any associated financial interests in the research or potential conflicts of interest. EDAT- 2014/09/30 06:00 MHDA- 2015/07/21 06:00 PMCR- 2015/11/01 CRDT- 2014/09/30 06:00 PHST- 2014/09/30 06:00 [entrez] PHST- 2014/09/30 06:00 [pubmed] PHST- 2015/07/21 06:00 [medline] PHST- 2015/11/01 00:00 [pmc-release] AID - S0741-8329(14)00151-7 [pii] AID - 10.1016/j.alcohol.2014.08.007 [doi] PST - ppublish SO - Alcohol. 2014 Nov;48(7):631-8. doi: 10.1016/j.alcohol.2014.08.007. Epub 2014 Aug 27.