PMID- 25262851
OWN - NLM
STAT- MEDLINE
DCOM- 20150717
LR  - 20211021
IS  - 1872-7492 (Electronic)
IS  - 0168-1702 (Print)
IS  - 0168-1702 (Linking)
VI  - 194
DP  - 2014 Dec 19
TI  - Modulation of innate immune signaling by nonstructural protein 1 (nsp1) in the 
      family Arteriviridae.
PG  - 100-9
LID - S0168-1702(14)00394-3 [pii]
LID - 10.1016/j.virusres.2014.09.007 [doi]
AB  - Arteriviruses infect immune cells and may cause persistence in infected hosts. 
      Inefficient induction of pro-inflammatory cytokines and type I IFNs are observed 
      during infection of this group of viruses, suggesting that they may have evolved 
      to escape the host immune surveillance for efficient survival. Recent studies 
      have identified viral proteins regulating the innate immune signaling, and among 
      these, nsp1 (nonstructural protein 1) is the most potent IFN antagonist. For 
      porcine reproductive and respiratory syndrome virus (PRRSV), individual subunits 
      (nsp1alpha and nsp1beta) of nsp1 suppress type I IFN production. In particular, 
      PRRSV-nsp1alpha degrades CREB (cyclic AMP responsive element binding)-binding protein 
      (CBP), a key component of the IFN enhanceosome, whereas PRRSV-nsp1beta degrades 
      karyopherin-alpha1 which is known to mediate the nuclear import of ISGF3 
      (interferon-stimulated gene factor 3). All individual subunits of nsp1 of PRRSV, 
      equine arteritis virus (EAV), lactate dehydrogenase-elevating virus (LDV), and 
      simian hemorrhagic fever virus (SHFV) appear to contain IFN suppressive 
      activities. As with PRRSV-nsp1alpha, CBP degradation is evident by LDV-nsp1alpha and 
      partly by SHFV-nsp1gamma. This review summarizes the biogenesis and the role of 
      individual subunits of nsp1 of arteriviruses for innate immune modulation.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Han, Mingyuan
AU  - Han M
AD  - Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, 
      IL 61802, USA.
FAU - Yoo, Dongwan
AU  - Yoo D
AD  - Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, 
      IL 61802, USA. Electronic address: dyoo@illinois.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20140928
PL  - Netherlands
TA  - Virus Res
JT  - Virus research
JID - 8410979
RN  - 0 (Interferon Type I)
RN  - 0 (Viral Nonstructural Proteins)
SB  - IM
MH  - Arterivirus/*immunology/*physiology
MH  - *Host-Pathogen Interactions
MH  - *Immune Evasion
MH  - *Immunity, Innate
MH  - Interferon Type I/*antagonists & inhibitors
MH  - Viral Nonstructural Proteins/*metabolism
PMC - PMC7114407
OTO - NOTNLM
OT  - Arterivirus
OT  - CREB-binding protein
OT  - Innate immunity
OT  - Interferon signaling
OT  - PRRSV
OT  - nsp1
EDAT- 2014/09/30 06:00
MHDA- 2015/07/18 06:00
PMCR- 2014/09/28
CRDT- 2014/09/30 06:00
PHST- 2014/08/18 00:00 [received]
PHST- 2014/09/16 00:00 [revised]
PHST- 2014/09/17 00:00 [accepted]
PHST- 2014/09/30 06:00 [entrez]
PHST- 2014/09/30 06:00 [pubmed]
PHST- 2015/07/18 06:00 [medline]
PHST- 2014/09/28 00:00 [pmc-release]
AID - S0168-1702(14)00394-3 [pii]
AID - 10.1016/j.virusres.2014.09.007 [doi]
PST - ppublish
SO  - Virus Res. 2014 Dec 19;194:100-9. doi: 10.1016/j.virusres.2014.09.007. Epub 2014 
      Sep 28.