PMID- 25262910
OWN - NLM
STAT- MEDLINE
DCOM- 20150821
LR  - 20200106
IS  - 1873-474X (Electronic)
IS  - 0736-5748 (Linking)
VI  - 38
DP  - 2014 Nov
TI  - Neonatal hypoxic-ischemic encephalopathy reduces c-Fos activation in the rat 
      hippocampus: evidence of a long-lasting effect.
PG  - 213-22
LID - S0736-5748(14)00163-4 [pii]
LID - 10.1016/j.ijdevneu.2014.09.003 [doi]
AB  - The effect of neonatal hypoxic-ischemic encephalopathy (HIE) on maturation of 
      nociceptive pathways has been sparsely explored. To investigate whether neonatal 
      HIE alters neuronal activity, nociceptive behavior, and serum neuroplasticity 
      mediators (brain-derived neurotrophic factor [BDNF] and tumor necrosis factor-alpha 
      [TNF]) in the short, medium, and long term. Neonate male Wistar rats were 
      randomized to receive a brain insult that could be either ischemic (left carotid 
      artery ligation [LCAL]), hypoxic (8% oxygen chamber), hypoxic-ischemic (LCAL and 
      hypoxic chamber), sham-ischemic, or sham-hypoxic. Neuronal activity (c-Fos 
      activation at region CA1 and dentate gyrus of the hippocampus), nociceptive 
      behavior (von Frey, tail-flick, and hot-plate tests), neuroplasticity mediators 
      (BDNF, TNF), and a cellular injury marker (lactase dehydrogenase [LDH]) were 
      assessed in blood serum 14, 30, and 60 days after birth. Neonatal HIE 
      persistently reduced c-Fos activation in the ipsilateral hippocampal region CA1; 
      however, contralateral c-Fos reduction appeared only 7 weeks after the event. 
      Neonatal HIE acutely reduced the paw withdrawal threshold (von Frey test), but 
      this returned to normal by the 30th postnatal day. Hypoxia reduced serum LDH 
      levels. Serum neuroplasticity mediators increased with age, and neonatal HIE did 
      not affect their ontogeny. Neonatal HIE-induced reduction in neuronal activity 
      occurs acutely in the ipsilateral hippocampal region CA1 and persists for at 
      least 60 days, but the contralateral effect of the insult is delayed. Alterations 
      in the nociceptive response are acute and self-limited. Serum neuroplasticity 
      mediators increase with age, and remain unaffected by HIE.
CI  - Copyright (c) 2014. Published by Elsevier Ltd.
FAU - Souza, Andressa
AU  - Souza A
AD  - Graduate Program in Medicine: Medical Sciences, Universidade Federal do Rio 
      Grande do Sul, 90035-003, Porto Alegre, Brazil; Pain Pharmacology and Animal 
      Models of Neuromodulation Laboratory, Department of Pharmacology, Institute of 
      Basic Health Sciences, Universidade Federal do Rio Grande do Sul, 90050-170, 
      Porto Alegre, Brazil; Animal Experimentation Unit, Hospital de Clinicas de Porto 
      Alegre Graduate Research Group, 90035-003, Porto Alegre, Brazil; Graduate Program 
      in Health and Human Development, Centro Universitario Unilasalle, 92010-000, 
      Canoas, Brazil.
FAU - Dussan-Sarria, Jairo Alberto
AU  - Dussan-Sarria JA
AD  - Graduate Program in Medicine: Medical Sciences, Universidade Federal do Rio 
      Grande do Sul, 90035-003, Porto Alegre, Brazil.
FAU - Medeiros, Liciane Fernandes
AU  - Medeiros LF
AD  - Graduate Program in Biological Sciences: Physiology, Universidade Federal do Rio 
      Grande do Sul, 90035-003, Porto Alegre, Brazil; Pain Pharmacology and Animal 
      Models of Neuromodulation Laboratory, Department of Pharmacology, Institute of 
      Basic Health Sciences, Universidade Federal do Rio Grande do Sul, 90050-170, 
      Porto Alegre, Brazil; Animal Experimentation Unit, Hospital de Clinicas de Porto 
      Alegre Graduate Research Group, 90035-003, Porto Alegre, Brazil.
FAU - Souza, Ana Claudia
AU  - Souza AC
AD  - Graduate Program in Medicine: Medical Sciences, Universidade Federal do Rio 
      Grande do Sul, 90035-003, Porto Alegre, Brazil; Pain Pharmacology and Animal 
      Models of Neuromodulation Laboratory, Department of Pharmacology, Institute of 
      Basic Health Sciences, Universidade Federal do Rio Grande do Sul, 90050-170, 
      Porto Alegre, Brazil; Animal Experimentation Unit, Hospital de Clinicas de Porto 
      Alegre Graduate Research Group, 90035-003, Porto Alegre, Brazil.
FAU - Oliveira, Carla
AU  - Oliveira C
AD  - Graduate Program in Medicine: Medical Sciences, Universidade Federal do Rio 
      Grande do Sul, 90035-003, Porto Alegre, Brazil; Pain Pharmacology and Animal 
      Models of Neuromodulation Laboratory, Department of Pharmacology, Institute of 
      Basic Health Sciences, Universidade Federal do Rio Grande do Sul, 90050-170, 
      Porto Alegre, Brazil; Animal Experimentation Unit, Hospital de Clinicas de Porto 
      Alegre Graduate Research Group, 90035-003, Porto Alegre, Brazil.
FAU - Scarabelot, Vanessa Leal
AU  - Scarabelot VL
AD  - Graduate Program in Biological Sciences: Physiology, Universidade Federal do Rio 
      Grande do Sul, 90035-003, Porto Alegre, Brazil; Pain Pharmacology and Animal 
      Models of Neuromodulation Laboratory, Department of Pharmacology, Institute of 
      Basic Health Sciences, Universidade Federal do Rio Grande do Sul, 90050-170, 
      Porto Alegre, Brazil; Animal Experimentation Unit, Hospital de Clinicas de Porto 
      Alegre Graduate Research Group, 90035-003, Porto Alegre, Brazil.
FAU - Adachi, Lauren Naomi
AU  - Adachi LN
AD  - Graduate Program in Medicine: Medical Sciences, Universidade Federal do Rio 
      Grande do Sul, 90035-003, Porto Alegre, Brazil; Pain Pharmacology and Animal 
      Models of Neuromodulation Laboratory, Department of Pharmacology, Institute of 
      Basic Health Sciences, Universidade Federal do Rio Grande do Sul, 90050-170, 
      Porto Alegre, Brazil; Animal Experimentation Unit, Hospital de Clinicas de Porto 
      Alegre Graduate Research Group, 90035-003, Porto Alegre, Brazil.
FAU - Winkelmann-Duarte, Elisa Cristiana
AU  - Winkelmann-Duarte EC
AD  - Department of Morphological Sciences, Universidade Federal de Santa Catarina, 
      88040-900, Florianopolis, Brazil.
FAU - Philippi-Martins, Barbara Beatriz
AU  - Philippi-Martins BB
AD  - Department of Morphological Sciences, Universidade Federal de Santa Catarina, 
      88040-900, Florianopolis, Brazil.
FAU - Netto, Carlos Alexandre
AU  - Netto CA
AD  - Pain Pharmacology and Animal Models of Neuromodulation Laboratory, Department of 
      Pharmacology, Institute of Basic Health Sciences, Universidade Federal do Rio 
      Grande do Sul, 90050-170, Porto Alegre, Brazil.
FAU - Caumo, Wolnei
AU  - Caumo W
AD  - Graduate Program in Medicine: Medical Sciences, Universidade Federal do Rio 
      Grande do Sul, 90035-003, Porto Alegre, Brazil.
FAU - Torres, Iraci L S
AU  - Torres IL
AD  - Graduate Program in Medicine: Medical Sciences, Universidade Federal do Rio 
      Grande do Sul, 90035-003, Porto Alegre, Brazil; Graduate Program in Biological 
      Sciences: Physiology, Universidade Federal do Rio Grande do Sul, 90035-003, Porto 
      Alegre, Brazil; Pain Pharmacology and Animal Models of Neuromodulation 
      Laboratory, Department of Pharmacology, Institute of Basic Health Sciences, 
      Universidade Federal do Rio Grande do Sul, 90050-170, Porto Alegre, Brazil; 
      Animal Experimentation Unit, Hospital de Clinicas de Porto Alegre Graduate 
      Research Group, 90035-003, Porto Alegre, Brazil. Electronic address: 
      iracitorres@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140927
PL  - United States
TA  - Int J Dev Neurosci
JT  - International journal of developmental neuroscience : the official journal of the 
      International Society for Developmental Neuroscience
JID - 8401784
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 1.1.1.27 (L-Lactate Dehydrogenase)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Animals, Newborn
MH  - Body Weight/physiology
MH  - Brain-Derived Neurotrophic Factor/blood
MH  - Disease Models, Animal
MH  - Gene Expression Regulation, Developmental/*physiology
MH  - Hippocampus/*metabolism
MH  - Hypoxia-Ischemia, Brain/blood/complications/*pathology
MH  - L-Lactate Dehydrogenase/metabolism
MH  - Male
MH  - Pain Measurement
MH  - Proto-Oncogene Proteins c-fos/*metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Reaction Time
MH  - Tumor Necrosis Factor-alpha/blood
OTO - NOTNLM
OT  - BDNF
OT  - Neonatal hypoxia-ischemia encephalopathy
OT  - Nociceptive behavior
OT  - TNF-alpha
OT  - c-Fos protein
EDAT- 2014/09/30 06:00
MHDA- 2015/08/22 06:00
CRDT- 2014/09/30 06:00
PHST- 2014/06/22 00:00 [received]
PHST- 2014/09/13 00:00 [revised]
PHST- 2014/09/16 00:00 [accepted]
PHST- 2014/09/30 06:00 [entrez]
PHST- 2014/09/30 06:00 [pubmed]
PHST- 2015/08/22 06:00 [medline]
AID - S0736-5748(14)00163-4 [pii]
AID - 10.1016/j.ijdevneu.2014.09.003 [doi]
PST - ppublish
SO  - Int J Dev Neurosci. 2014 Nov;38:213-22. doi: 10.1016/j.ijdevneu.2014.09.003. Epub 
      2014 Sep 27.