PMID- 25262921
OWN - NLM
STAT- MEDLINE
DCOM- 20150611
LR  - 20140929
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 84
IP  - 4
DP  - 2014 Oct
TI  - Minor histocompatibility antigens: past, present, and future.
PG  - 374-60
LID - 10.1111/tan.12445 [doi]
AB  - Minor histocompatibility (H) antigens are key molecules driving allo-immune 
      responses in both graft-versus-host-disease (GvHD) and in graft-versus-leukemia 
      (GvL) reactivity in human leukocyte antigen (HLA)-matched hematopoietic stem-cell 
      transplantation (HSCT). Dissection of the dual function of minor H antigens 
      became evident through their different modes of tissue and cell expression, i.e. 
      hematopoietic system-restricted or broad. Broadly expressed minor H antigens can 
      cause both GvHD and GvL effects, while hematopoietic system-restricted minor H 
      antigens are more prone to induce GvL responses. This phenomenon renders the 
      latter group of minor H antigens as curative tools for HSCT-based immunotherapy 
      of hematological malignancies and disorders, in which minor H antigen-specific 
      responses are enhanced in order to eradicate the malignant cells. This article 
      describes the immunogenetics of minor H antigens and methods that have been 
      developed to identify them. Moreover, it summarizes the clinical relevance of 
      minor H antigens in transplantation, with special regards to allogeneic HSCT and 
      solid-organ transplantation.
CI  - (c) 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Spierings, Eric
AU  - Spierings E
AD  - Laboratory for Translational Immunology, University Medical Center Utrecht, 
      Utrecht, the Netherlands.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (Minor Histocompatibility Antigens)
SB  - IM
MH  - Allografts
MH  - Graft vs Host Disease/*genetics/immunology/prevention & control
MH  - Graft vs Leukemia Effect/*genetics/immunology
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Histocompatibility Testing
MH  - Humans
MH  - Minor Histocompatibility Antigens/*genetics/immunology
MH  - *Organ Transplantation
OTO - NOTNLM
OT  - adoptive immunotherapy
OT  - allo-immunity
OT  - graft-versus-host disease
OT  - graft-versus-leukemia effect
OT  - hematopoietic stem-cell transplantation
OT  - immunogenetics
OT  - minor H antigens
OT  - organ transplantation
EDAT- 2014/09/30 06:00
MHDA- 2015/06/13 06:00
CRDT- 2014/09/30 06:00
PHST- 2014/08/20 00:00 [received]
PHST- 2014/09/30 06:00 [entrez]
PHST- 2014/09/30 06:00 [pubmed]
PHST- 2015/06/13 06:00 [medline]
AID - 10.1111/tan.12445 [doi]
PST - ppublish
SO  - Tissue Antigens. 2014 Oct;84(4):374-60. doi: 10.1111/tan.12445.